Zobrazeno 1 - 10
of 197
pro vyhledávání: '"Kirstan K. Meldrum"'
Autor:
Cody C. Gifford, Stephen P. Higgins, Craig E. Higgins, David J. Conti, Paul J. Higgins, Kirstan K. Meldrum, Jiaqi Tang, Badar M. Mian, Rohan Samarakoon
Publikováno v:
FASEB J
Chronic kidney disease affects >15% of the U.S. population and >850 million individuals worldwide. Fibrosis is the common outcome of many chronic renal disorders and, although the etiology varies (i.e., diabetes, hypertension, ischemia, acute injury,
Autor:
Ethan I Franke, Brian A Vanderbrink, Karen L Hile, Hongji Zhang, Alexandra Cain, Futoshi Matsui, Kirstan K Meldrum
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47417 (2012)
Interleukin 18 (IL-18) is a pro-inflammatory cytokine that mediates fibrotic renal injury during obstruction. Macrophages are a well-known source of IL-18; however, renal tubular epithelial cells are also a potential source of this cytokine. We hypot
Externí odkaz:
https://doaj.org/article/eedcf6d8a4f34ae688b4c7e3b34a7549
Autor:
Theodore Barber, Kevin Ginsburg, Kahlil Saad, Brian Roelof, Kirstan K. Meldrum, Jesse Jacobs, George F. Steinhardt
Publikováno v:
Journal of Urology. 197
Publikováno v:
Cellular Signalling. 26:1427-1436
Transforming growth factor-β1 (TGF-β1) regulates the tissue response to injury and is the principal driver of excessive scarring leading to fibrosis and eventual organ failure. The TGF-β1 effectors SMAD3 and p53 are major contributors to disease p
Autor:
Samik Patel, Paul J. Higgins, Catherine Cooley, Rohan Samarakoon, Jessica M. Overstreet, Amy D. Dobberfuhl, Kirstan K. Meldrum, Roel Goldschmeding
Publikováno v:
Cellular Signalling. 25:2198-2209
While transforming growth factor-β (TGF-β1)-induced SMAD2/3 signaling is a critical event in the progression of chronic kidney disease, the role of non-SMAD mechanisms in the orchestration of fibrotic gene changes remains largely unexplored. TGF-β
Autor:
Kirstan K. Meldrum, Martin Kaefer, Brian A. VanderBrink, Richard C. Rink, Rosalia Misseri, Mark P. Cain
Publikováno v:
Journal of Pediatric Surgery. 48:2134-2139
Background/Purpose The Malone antegrade continence enema (MACE) channel is an effective means to manage patients with neurogenic bowel; however, complications may occur that may require surgical revision. Specific reports of the outcomes of these int
Publikováno v:
American Journal of Physiology-Renal Physiology. 305:F1014-F1021
IL-18 is an important mediator of obstruction-induced renal fibrosis and renal tubular epithelial cell (TEC) injury. IL-18's proinflammatory properties have been attributed, in part, to NF-κB activation and the stimulation of cytokine gene expressio
Autor:
Hongji Zhang, Futoshi Matsui, Kirstan K. Meldrum, Audrey C. Rhee, Alexandra Cain, Karen L. Hile
Publikováno v:
Journal of Surgical Research. 183:278-284
Purpose Interleukin 18 (IL-18) is a critical mediator of obstruction-induced renal injury. Although previous studies have demonstrated that IL-18 participates in a positive feedback loop via the IL-18 receptor (IL-18R) and localized renal IL-18 and I
Autor:
Futoshi Matsui, Kirstan K. Meldrum
Publikováno v:
Journal of Surgical Research. 178:339-345
Over the past several years, a number of cytokines and growth factors including transforming growth factor β1, tumor necrosis factor α, and angiotensin II have been shown to play a crucial role in renal fibrosis. The Janus kinase family (JAK) and s
Autor:
Ethan I. Franke, Kirstan K. Meldrum
Publikováno v:
Current Pediatric Reviews. 7:346-351