Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Kirsi Riento"'
Autor:
Kirsi Riento, Qifeng Zhang, Jonathan Clark, Farida Begum, Elaine Stephens, Michael J Wakelam, Benjamin J Nichols
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197401 (2018)
Sphingosine-1-phosphate (S1P) is an important lipid signalling molecule. S1P is produced via intracellular phosphorylation of sphingosine (Sph). As a lipid with a single fatty alkyl chain, Sph may diffuse rapidly between cellular membranes and throug
Externí odkaz:
https://doaj.org/article/4883ceaeb29a4a958084f6c5761376e5
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85217 (2014)
Flotillin 1 and flotillin 2 associate in the plasma membrane to form microdomains that have roles in cell signaling, regulation of cell-cell contacts, membrane-cytoskeletal interactions, and endocytosis. They are thought to be involved in the traffic
Externí odkaz:
https://doaj.org/article/f7e39ec8ff70476ba34e86bddcc086fa
Autor:
Michael J.O. Wakelam, Jonathan Clark, Kirsi Riento, Elaine Stephens, Qifeng Zhang, Benjamin J. Nichols, Farida Begum
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 5, p e0197401 (2018)
PLoS ONE, Vol 13, Iss 5, p e0197401 (2018)
Sphingosine-1-phosphate (S1P) is an important lipid signalling molecule. S1P is produced via intracellular phosphorylation of sphingosine (Sph). As a lipid with a single fatty alkyl chain, Sph may diffuse rapidly between cellular membranes and throug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c999a34de7f8915829a15eae2a01bbee
https://pubmed.ncbi.nlm.nih.gov/29787576
https://pubmed.ncbi.nlm.nih.gov/29787576
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0209856 (2018)
PLoS ONE
PLoS ONE
The mechanisms controlling the abundance and sub-cellular distribution of caveolae are not well described. A first step towards determining such mechanisms would be identification of relevant proteins that interact with known components of caveolae.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ca291f2fbf26e692fc761225657f9c7
https://doaj.org/article/6a8c0fc9e1dc427ea31cbee771592ede
https://doaj.org/article/6a8c0fc9e1dc427ea31cbee771592ede
Publikováno v:
The Journal of Cell Biology
The association between flotillin microdomains and the cortical cytoskeleton controls myosin IIa activation and neutrophil chemotaxis.
We studied the function of plasma membrane microdomains defined by the proteins flotillin 1 and flotillin 2 in
We studied the function of plasma membrane microdomains defined by the proteins flotillin 1 and flotillin 2 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c24bb1e8fd1ce67e27a1de677b95cfc
https://doi.org/10.1083/jcb.201005140
https://doi.org/10.1083/jcb.201005140
Publikováno v:
Biochemical Journal. 411:407-414
ROCK-I (Rho-associated kinase 1) is a serine/threonine kinase that can be activated by RhoA and inhibited by RhoE. ROCK-I has an N-terminal kinase domain, a central coiled-coil region and a RhoA-binding domain near the C-terminus. We have previously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37145e186eccca578ff546c1f286e33a
https://doi.org/10.1042/bj20071342
https://doi.org/10.1042/bj20071342
Publikováno v:
Molecular and Cellular Biology. 24:7829-7840
Rho GTPases are major regulators of cytoskeletal dynamics, but they also affect cell proliferation, transformation, and oncogenesis. RhoE, a member of the Rnd subfamily that does not detectably hydrolyze GTP, inhibits RhoA/ROCK signaling to promote a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa7712bd0f89a0fb6adc65fa1a91c70
https://doi.org/10.1128/mcb.24.18.7829-7840.2004
https://doi.org/10.1128/mcb.24.18.7829-7840.2004
Publikováno v:
Molecular and Cellular Biology. 23:4219-4229
RhoE belongs to the Rho GTPase family, the members of which control actin cytoskeletal dynamics. RhoE induces stress fiber disassembly in a variety of cell types, whereas RhoA stimulates stress fiber assembly. The similarity of RhoE and RhoA sequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ce261046f56373c8d1cfe0e98f5302
https://doi.org/10.1128/mcb.23.12.4219-4229.2003
https://doi.org/10.1128/mcb.23.12.4219-4229.2003
Autor:
John P. Phelan, Mark S. B. McAlister, Halina Garavini, Nicholas H. Keep, Kirsi Riento, and Anne J. Ridley
Publikováno v:
Biochemistry. 41:6303-6310
We report the 2.1 A crystal structure of the core G protein domain of the unusual Rho family member RhoE/Rnd3 in complex with endogenous GTP and magnesium. Unlike other small G proteins, RhoE, along with two other proteins Rnd1/Rho6 and Rnd2/RhoN, do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101736986793d840ca7d8a986338f403
https://doi.org/10.1021/bi025651h
https://doi.org/10.1021/bi025651h
Autor:
Stanislav Lazarev, Kamran Atabai, Kirsi Riento, Stephen L. Nishimura, Amin Khalifeh-Soltani, William McKleroy, Stephen Sakuma, Ben J. Nichols, Ting-Hein Lee
Publikováno v:
Molecular Biology of the Cell
Novel mediators of cell-mediated collagen turnover are identified through an RNAi screen targeting Drosophila genes with metazoan orthologues. Flotillin genes are key regulators of collagen turnover in mammalian cells and work by stabilizing expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9df39bee5c1fedd8fc4ef2c03b5d9b50
https://pubmed.ncbi.nlm.nih.gov/24403604
https://pubmed.ncbi.nlm.nih.gov/24403604