Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Kirsi A Virtanen"'
Autor:
Maija Vaittinen, Mariana Ilha, Ratika Sehgal, Maria A. Lankinen, Jyrki Ågren, Pirjo Käkelä, Kirsi A. Virtanen, Markku Laakso, Ursula Schwab, Jussi Pihlajamäki
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 10, Pp 100638- (2024)
Fatty acid desaturase (FADS1) variant-rs174550 strongly regulates polyunsaturated fatty acid (PUFA) biosynthesis. Additionally, the FADS1 is related to mitochondrial function. Thus, we investigated whether changes in mitochondrial function are associ
Externí odkaz:
https://doaj.org/article/d3b052760a2344f388e153954ad02561
Autor:
Mueez U-Din, Vanessa D. de Mello, Marjo Tuomainen, Juho Raiko, Tarja Niemi, Tobias Fromme, Anton Klåvus, Nadine Gautier, Kimmo Haimilahti, Marko Lehtonen, Karsten Kristiansen, John W. Newman, Kirsi H. Pietiläinen, Jussi Pihlajamäki, Ez-Zoubir Amri, Martin Klingenspor, Pirjo Nuutila, Eija Pirinen, Kati Hanhineva, Kirsi A. Virtanen
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113131- (2023)
Summary: Cold-induced brown adipose tissue (BAT) activation is considered to improve metabolic health. In murine BAT, cold increases the fundamental molecule for mitochondrial function, nicotinamide adenine dinucleotide (NAD+), but limited knowledge
Externí odkaz:
https://doaj.org/article/1c0fa9c527de49b8bd7b766598b67913
Autor:
Elina Rauhala, Jarkko Johansson, Mira Karrasch, Olli Eskola, Tuula Tolvanen, Riitta Parkkola, Kirsi A. Virtanen, Juha O. Rinne
Publikováno v:
EJNMMI Research, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Background Our aim was to investigate the discriminative value of 18F-Flutemetamol PET in longitudinal assessment of amyloid beta accumulation in amnestic mild cognitive impairment (aMCI) patients, in relation to longitudinal cognitive chang
Externí odkaz:
https://doaj.org/article/3f03f8e1508e4f8ab0380db0abe4eac3
Autor:
Vanessa Pellegrinelli, Elizabeth Figueroa-Juárez, Isabella Samuelson, Mueez U-Din, Sonia Rodriguez-Fdez, Samuel Virtue, Jennifer Leggat, Cankut Çubuk, Vivian J. Peirce, Tarja Niemi, Mark Campbell, Sergio Rodriguez-Cuenca, Joaquin Dopazo Blázquez, Stefania Carobbio, Kirsi A. Virtanen, Antonio Vidal-Puig
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112640- (2023)
Summary: The relevance of extracellular matrix (ECM) remodeling is reported in white adipose tissue (AT) and obesity-related dysfunctions, but little is known about the importance of ECM remodeling in brown AT (BAT) function. Here, we show that a tim
Externí odkaz:
https://doaj.org/article/abc6d1bed4df4ab1bb326033123fcdff
Autor:
Maria K. Jaakkola, Maria Rantala, Anna Jalo, Teemu Saari, Jaakko Hentilä, Jatta S. Helin, Tuuli A. Nissinen, Olli Eskola, Johan Rajander, Kirsi A. Virtanen, Jarna C. Hannukainen, Francisco López-Picón, Riku Klén
Publikováno v:
International Journal of Biomedical Imaging, Vol 2023 (2023)
Clustering time activity curves of PET images have been used to separate clinically relevant areas of the brain or tumours. However, PET image segmentation in multiorgan level is much less studied due to the available total-body data being limited to
Externí odkaz:
https://doaj.org/article/6aa8f6b2dabe4568b37638f9a31ae1fe
Autor:
Lucia Balazova, Miroslav Balaz, Carla Horvath, Áron Horváth, Caroline Moser, Zuzana Kovanicova, Adhideb Ghosh, Umesh Ghoshdastider, Vissarion Efthymiou, Elke Kiehlmann, Wenfei Sun, Hua Dong, Lianggong Ding, Ez-Zoubir Amri, Pirjo Nuutila, Kirsi A. Virtanen, Tarja Niemi, Barbara Ukropcova, Jozef Ukropec, Pawel Pelczar, Thorsten Lamla, Bradford Hamilton, Heike Neubauer, Christian Wolfrum
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Activation of thermogenic adipocytes is a strategy to combat metabolic diseases. Here the authors report that GPR180 is a component of TGFβ signalling that promotes thermogenic adipocyte function and mediates the metabolic effects of the adipocyte-s
Externí odkaz:
https://doaj.org/article/88ee4530cad64964a1bb8fbac9b2b659
Autor:
Milena Monfort-Pires, Giulianna Regeni-Silva, Prince Dadson, Guilherme A. Nogueira, Mueez U-Din, Sandra R. G. Ferreira, Marcelo Tatit Sapienza, Kirsi A. Virtanen, Licio A. Velloso
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Brown adipose tissue (BAT) is regarded as an interesting potential target for the treatment of obesity, diabetes, and cardiovascular diseases, and the detailed characterization of its structural and functional phenotype could enable an advance in the
Externí odkaz:
https://doaj.org/article/69ef5758c13f4cf3b8c14af8f3b1d2a7
Autor:
Roeland J. W. Middelbeek, Piryanka Motiani, Nina Brandt, Pasquale Nigro, Jia Zheng, Kirsi A. Virtanen, Kari K. Kalliokoski, Jarna C. Hannukainen, Laurie J. Goodyear
Publikováno v:
Nutrition & Diabetes, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Background Short-term exercise training programs that consist of moderate intensity endurance training or high intensity interval training have become popular choices for healthy lifestyle modifications, with as little as two weeks of traini
Externí odkaz:
https://doaj.org/article/a19549efa3214843a3e54787aff95842
Thermogenic Capacity of Human Supraclavicular Brown Fat and Cold-Stimulated Brain Glucose Metabolism
Autor:
Mueez U-Din, Eleni Rebelos, Teemu Saari, Tarja Niemi, Katharina Kuellmer, Olli Eskola, Tobias Fromme, Johan Rajander, Markku Taittonen, Martin Klingenspor, Pirjo Nuutila, Lauri Nummenmaa, Kirsi A. Virtanen
Publikováno v:
Metabolites, Vol 13, Iss 3, p 387 (2023)
Human brain metabolism is susceptible to temperature changes. It has been suggested that the supraclavicular brown adipose tissue (BAT) protects the brain from these fluctuations by regulating heat production through the presence of uncoupling protei
Externí odkaz:
https://doaj.org/article/082d0503447f4feeb726d4e3fc5d3e17
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/8d42244c91444f6790d6e8dac7cce2e0