Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Kirsi, Narko"'
Autor:
Ilkka Tikkanen, Kirsi Narko, Alexandra Green, Uli C. Broedl, Hans-Juergen Woerle, Afshin Salsali, Cordula Zeller
Publikováno v:
Diabetes Care. 38:420-428
OBJECTIVE To investigate the efficacy, safety, and tolerability of empagliflozin in patients with type 2 diabetes and hypertension. RESEARCH DESIGN AND METHODS Patients (N = 825) with type 2 diabetes and hypertension (mean seated systolic blood press
Autor:
Tomi P. Mäkelä, Mira Heinonen, Alexandra Thiel, Marie-Christine Rio, Ari Ristimäki, Annabrita Hemmes, Kirsi Narko, Caj Haglund, Catherine Tomasetto
Publikováno v:
International Journal of Cancer. 131:1032-1041
Cyclooxygenase-2 (Cox-2) expression is a marker of reduced survival in gastric cancer patients, and inhibition of Cox-2 suppresses gastrointestinal carcinogenesis in experimental animal models. To investigate the role of Cox-2 in gastric carcinogenes
Publikováno v:
Prostaglandins & Other Lipid Mediators. 88:97-100
Cyclooxygenase-2 (COX-2), overexpressed in inflammatory conditions and cancer, regulates angiogenesis and tumorigenesis via the production of biologically active prostanoids. Previously, we showed that COX-2 over-expression in the mammary gland of tr
Autor:
Henry Furneaux, Heikki Joensuu, Caj Haglund, Johan Lundin, Mira Heinonen, Timothy Hla, Sung-Hee Chang, Petri Bono, Kirsi Narko, Ari Ristimäki
Publikováno v:
Cancer Research. 65:2157-2161
HuR is a ubiquitously expressed mRNA-binding protein. Intracellular localization of HuR is predominantly nuclear, but it shuttles between the nucleus and the cytoplasm. In the cytoplasm it can stabilize certain transcripts. Because nucleocytoplasmic
Publikováno v:
International Journal of Experimental Pathology. 80:109-112
The development of the vascular system involves vasculogenesis and angiogenesis. In vasculogenesis the endothelium of blood vessels forms by in situ differentiation from precursor cells called angioblasts. During later embryogenesis and adult life th
Publikováno v:
Endocrinology. 138:3638-3644
Prostanoids are important regulators of ovarian function, especially during ovulation and luteolysis. Cyclooxygenase (Cox) is the rate-limiting enzyme in conversion of arachidonic acid to prostanoids. We have examined the expression and regulation of
Autor:
Timothy Hla, Christian C. Haudenschild, Kirsi Narko, Elizabeth Smith, Martin Macphee, Ari Ristimäki
Publikováno v:
Journal of Biological Chemistry. 272:21455-21460
The cyclooxygenase (Cox) enzyme catalyzes the rate-limiting oxidative and peroxidative enzymatic steps in the biosynthesis of prostanoids. Both Cox-1 and -2 genes encode the two isoenzymes that carry out similar enzymatic steps. Enhanced Cox activity
Publikováno v:
Scopus-Elsevier
The immediate-early cyclo-oxygenase-2 (Cox-2) gene encodes an inducible prostaglandin synthase enzyme that has been implicated in inflammatory and proliferative diseases. We have shown that the inflammatory cytokine interleukin-1 (IL-1) induces the C
Publikováno v:
Human Immunology. 43:66-71
The usefulness of rare neutral gene polymorphisms as an HLA haplotype marker and as a probe for founder effect in small populations was tested by determining the frequency and MHC associations of an Ncol polymorphism in the P450c21 genes in the Finni
Publikováno v:
Prostaglandinsother lipid mediators. 76(1-4)
Cyclooxygenase-2 (COX-2) overexpression is a widely recognized feature of human breast cancer and inhibitors of the enzyme have antitumor effects in a subset of tumor settings. Previously, we demonstrated that direct overexpression of COX-2 under con