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Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age

Autor: Doris Lechner, Miriam Capri, Stefan Böhringer, Stefan Schreiber, Gonneke Willemsen, Paolo Garagnani, Irene Maeve Rea, Andres Metspalu, Palmi V. Jonsson, Thomas B. L. Kirkwood, Lene Christiansen, Fernando Rivadeneira, Giuseppina Rose, J. Wouter Jukema, Serena Dato, Owen A. Ross, Almut Nebel, Cornelia M. van Duijn, Gary Saunders, Bernard Jeune, David J. Stott, Jeanine J. Houwing-Duistermaat, A. Murphy, Anton J. M. de Craen, Friederike Flachsbart, Karen Andersen-Ranberg, Albert Hofman, Ian Ford, Ellen A. Nohr, Giuseppe Passarino, Krista Fischer, Elisa Cevenini, Carmen Martin-Ruiz, Jutta Gampe, Iris Postmus, Christopher P. Nelson, Stefano Salvioli, Alberto Montesanto, Mark Lathrop, Marianne Nygaard, Marie E. Breen, Jennifer Harrow, Hae-Won Uh, Erik B. van den Akker, Thorkild I. A. Sørensen, André G. Uitterlinden, Alexander Viktorin, Bastiaan T. Heijmans, Susan E. McNerlan, Quinta Helmer, Naveed Sattar, Claudio Franceschi, Eco J. C. de Geus, E. Mihailov, Jouke-Jan Hottenga, Qihua Tan, Kari Stefansson, Yoichiro Kamatani, Paolina Crocco, Henning Tiemeier, Stella Trompet, Patrik K. E. Magnusson, Marian Beekman, Riin Tamm, Amke Caliebe, Maris Alver, Femke-Anouska Heinsen, Pilar Galan, Daníel F. Guðbjartsson, Joris Deelen, Linda Broer, Ruud van der Breggen, Kristin L. Ayers, Anna M. Bennet, Dorret I. Boomsma, P. Eline Slagboom, Kaare Christensen, Diana van Heemst, Joanna Collerton, Karen Davies, Rudi G. J. Westendorp, Hélène Blanché, Lavinia Paternoster, Nilesh J. Samani, Hreinn Stefansson, Simon P. Mooijaart, Heather J. Cordell

Publikováno v: Human Molecular Genetics
Human Molecular Genetics, Oxford University Press (OUP), 2014, 23 (16), pp.4420-32. ⟨10.1093/hmg/ddu139⟩
Human Molecular Genetics, 23(16), 4420-4432. Oxford University Press
Human Molecular Genetics; Vol 23
Hum Mol Genet
Deelen, J, Beekman, M, Uh, H-W, Broer, L, Ayers, K L, Tan, Q, Kamatani, Y, Bennet, A M, Tamm, R, Trompet, S, Guðbjartsson, D F, Flachsbart, F, Rose, G, Viktorin, A, Fischer, K, Nygaard, M, Cordell, H J, Crocco, P, van den Akker, E B, Böhringer, S, Helmer, Q, Nelson, C P, Saunders, G I, Alver, M, Anderson-Ranberg, K, Breen, M E, van der Breggen, R, Caliebe, A, Capri, M, Cevenini, E, Collerton, J C, Dato, S, Davies, K, Ford, I, Gampe, J, Garagnani, P, de Geus, E J C, Harrow, J, van Heemst, D, Heijmans, B T, Heinsen, F-A, Hottenga, J-J, Hofman, A, Juene, B, Jonsson, P V, Lathrop, M, Lechner, D, Martin-Ruiz, C, Mcnerlan, S E, Mihailov, E, Montesanto, A, Mooijaart, S P, Murphy, A, Nohr, E A, Paternoster, L, Postmus, I, Rivadeneira, F, Ross, O A, Salvioli, S, Sattar, N, Schreiber, S, Stefánsson, H, Stott, D J, Tiemeier, H, Uitterlinden, A G, Westendorp, R G J, Willemsen, G, Samani, N J, Galan, P, Sørensen, T I A, Boomsma, D I, Jukema, J W, Rea, I M, Passarino, G, de Craen, A J M, Christensen, K, Nebel, A, Stefánsson, K, Metspalu, A, Magnusson, P, Blanché, H, Christiansen, L, Kirkwood, T B L, van Duijn, C M, Franceschi, C, Houwing-Duistermaat, J J & Slagboom, P E 2014, ' Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age ', Human Molecular Genetics, vol. 23, no. 6, pp. 4420-4432 . https://doi.org/10.1093/hmg/ddu139
Deelen, J, Beekman, M, Uh, H-W, Broer, L, Ayers, K L, Tan, Q, Kamatani, Y, Bennet, A M, Tamm, R, Trompet, S, Guðbjartsson, D F, Flachsbart, F, Rose, G, Viktorin, A, Fischer, K, Nygaard, M, Cordell, H J, Crocco, P, van den Akker, E B, Böhringer, S, Helmer, Q, Nelson, C P, Saunders, G I, Alver, M, Andersen-Ranberg, K, Breen, M E, van der Breggen, R, Caliebe, A, Capri, M, Cevenini, E, Collerton, J C, Dato, S, Davies, K, Ford, I, Gampe, J, Garagnani, P, de Geus, E J C, Harrow, J, van Heemst, D, Heijmans, B T, Heinsen, F-A, Hottenga, J-J, Hofman, A, Jeune, B, Jonsson, P V, Lathrop, M, Lechner, D, Martin-Ruiz, C, McNerlan, S E, Mihailov, E, Montesanto, A, Mooijaart, S P, Murphy, A, Nohr, E A, Paternoster, L, Postmus, I, Rivadeneira, F, Ross, O A, Salvioli, S, Sattar, N, Schreiber, S, Stefánsson, H, Stott, D J, Tiemeier, H, Uitterlinden, A G, Westendorp, R G J, Willemsen, G, Samani, N J, Galan, P, Sørensen, T I A, Boomsma, D I, Jukema, J W, Rea, I M, Passarino, G, de Craen, A J M, Christensen, K, Nebel, A, Stefánsson, K, Metspalu, A, Magnusson, P, Blanché, H, Christiansen, L, Kirkwood, T B L, van Duijn, C M, Franceschi, C, Houwing-Duistermaat, J J & Slagboom, P E 2014, ' Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age ', Human Molecular Genetics, vol. 23, no. 16, ddu139, pp. 4420-4432 . https://doi.org/10.1093/hmg/ddu139
Human Molecular Genetics, 23(16), 4420-4432
Deelen, J, Beekman, M, Uh, H W, Broer, L, Ayers, K L, Tan, Q, Kamatani, Y, Bennet, A M, Tamm, R, Trompet, S, Gudbjartsson, D F, Flachsbart, F, Rose, G, Viktorin, A, Fischer, K, Nygaard, M, Cordell, H J, Crocco, P, van den Akker, E B, Böhringer, S, Helmer, Q, Nelson, C P, Saunders, G I, Alver, M, Andersen-Ranberg, K, Breen, M E, van der Breggen, R, Caliebe, A, Capri, M, Cevenini, E, Collerton, J C, Dato, S, Davies, K, Ford, I, Gampe, J, Garagnani, P, de Geus, E J C, Harrow, J, van Heemst, D, Heijmans, B T, Heinsen, F A, Hottenga, J J, Hofman, A, Jeune, B, Jonsson, P V, Lathrop, M, Lechner, D, Martin-Ruiz, C, McNerlan, S E, Mihailov, E, Montesanto, A, Mooijaart, S P, Murphy, A, Nohr, E A, Paternoster, L, Postmus, I, Rivadeneira, F, Ross, O A, Salvioli, S, Sattar, N, Schreiber, S, Stefansson, H, Stott, D J, Tiemeier, H, Uitterlinden, A G, Westendorp, R G J, Willemsen, G, Samani, N J, Galan, P, Sørensen, T I A, Boomsma, D I, Jukema, J W, Maeve Rea, I, Passarino, G, de Craen, A J, Christensen, K, Nebel, A, Stefansson, K, Metspalu, A, Magnusson, P, Blanché, H, Christiansen, L, Kirkwood, T B L, van Duijn, C M, Franceschi, C, Houwing-Duistermaat, J J & Slagboom, P E 2014, ' Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age ', Human Molecular Genetics, vol. 23, no. 16, pp. 4420-4432 . https://doi.org/10.1093/hmg/ddu139

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https://hal.inrae.fr/hal-02638826

Age-related macular degeneration: A two-level model hypothesis.

Autor: Rozing MP; The Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark; Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Durhuus JA; Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark., Krogh Nielsen M; Clinical Eye Research Division, Department of Ophthalmology, Zealand University, Hospital, Roskilde and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Subhi Y; Clinical Eye Research Division, Department of Ophthalmology, Zealand University, Hospital, Roskilde and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Kirkwood TB; Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark., Westendorp RG; Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Public Health, Section of Epidemiology, University of Copenhagen, Copenhagen, Denmark., Sørensen TL; Clinical Eye Research Division, Department of Ophthalmology, Zealand University, Hospital, Roskilde and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. Electronic address: tlso@regionsjaelland.dk.

Publikováno v: Progress in retinal and eye research [Prog Retin Eye Res] 2020 May; Vol. 76, pp. 100825. Date of Electronic Publication: 2019 Dec 30.

Prevalence and incidence of sarcopenia in the very old: findings from the Newcastle 85+ Study.

Autor: Dodds RM; Academic Geriatric Medicine, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, Hampshire, UK.; Ageing Geriatrics and Epidemiology, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE4 5PL, Tyne and Wear, UK., Granic A; Ageing Geriatrics and Epidemiology, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE4 5PL, Tyne and Wear, UK.; NIHR Newcastle Biomedical Research Centre, Newcastle University and Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, NE4 5PL, Tyne and Wear, UK.; Institute for Ageing, Newcastle University, Newcastle upon Tyne, NE4 5PL, Tyne and Wear, UK., Davies K; Ageing Geriatrics and Epidemiology, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE4 5PL, Tyne and Wear, UK.; NIHR Newcastle Biomedical Research Centre, Newcastle University and Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, NE4 5PL, Tyne and Wear, UK.; Institute for Ageing, Newcastle University, Newcastle upon Tyne, NE4 5PL, Tyne and Wear, UK., Kirkwood TB; NIHR Newcastle Biomedical Research Centre, Newcastle University and Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, NE4 5PL, Tyne and Wear, UK.; Institute for Ageing, Newcastle University, Newcastle upon Tyne, NE4 5PL, Tyne and Wear, UK.; Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, NE1 7RU, Tyne and Wear, UK., Jagger C; NIHR Newcastle Biomedical Research Centre, Newcastle University and Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, NE4 5PL, Tyne and Wear, UK.; Institute for Ageing, Newcastle University, Newcastle upon Tyne, NE4 5PL, Tyne and Wear, UK.; Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Tyne and Wear, UK., Sayer AA; Academic Geriatric Medicine, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, Hampshire, UK.; Ageing Geriatrics and Epidemiology, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE4 5PL, Tyne and Wear, UK.; NIHR Newcastle Biomedical Research Centre, Newcastle University and Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, NE4 5PL, Tyne and Wear, UK.; Institute for Ageing, Newcastle University, Newcastle upon Tyne, NE4 5PL, Tyne and Wear, UK.; MRC Lifecourse Epidemiology Unit, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, Hampshire, UK.; NIHR Collaboration for Leadership in Applied Health Research and Care Wessex, University of Southampton, Southampton, Hamphsire, UK.

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Serum Thyroid Function, Mortality and Disability in Advanced Old Age: The Newcastle 85+ Study.

Autor: Pearce SH; Institute of Genetic Medicine (S.H.S.P., S.R.), Newcastle University, Newcastle upon Tyne NE1 3BZ, United Kingdom; Institute of Health and Society (M.E.Y., C.M.-R., A.K., J.C., T.B.K., C.J.), Newcastle University, Newcastle upon Tyne NE2 4AX, United Kingdom; and Department of Internal Medicine (T.J.V.), Erasmus Medical Center, Rotterdam, The Netherlands., Razvi S; Institute of Genetic Medicine (S.H.S.P., S.R.), Newcastle University, Newcastle upon Tyne NE1 3BZ, United Kingdom; Institute of Health and Society (M.E.Y., C.M.-R., A.K., J.C., T.B.K., C.J.), Newcastle University, Newcastle upon Tyne NE2 4AX, United Kingdom; and Department of Internal Medicine (T.J.V.), Erasmus Medical Center, Rotterdam, The Netherlands., Yadegarfar ME; Institute of Genetic Medicine (S.H.S.P., S.R.), Newcastle University, Newcastle upon Tyne NE1 3BZ, United Kingdom; Institute of Health and Society (M.E.Y., C.M.-R., A.K., J.C., T.B.K., C.J.), Newcastle University, Newcastle upon Tyne NE2 4AX, United Kingdom; and Department of Internal Medicine (T.J.V.), Erasmus Medical Center, Rotterdam, The Netherlands., Martin-Ruiz C; Institute of Genetic Medicine (S.H.S.P., S.R.), Newcastle University, Newcastle upon Tyne NE1 3BZ, United Kingdom; Institute of Health and Society (M.E.Y., C.M.-R., A.K., J.C., T.B.K., C.J.), Newcastle University, Newcastle upon Tyne NE2 4AX, United Kingdom; and Department of Internal Medicine (T.J.V.), Erasmus Medical Center, Rotterdam, The Netherlands., Kingston A; Institute of Genetic Medicine (S.H.S.P., S.R.), Newcastle University, Newcastle upon Tyne NE1 3BZ, United Kingdom; Institute of Health and Society (M.E.Y., C.M.-R., A.K., J.C., T.B.K., C.J.), Newcastle University, Newcastle upon Tyne NE2 4AX, United Kingdom; and Department of Internal Medicine (T.J.V.), Erasmus Medical Center, Rotterdam, The Netherlands., Collerton J; Institute of Genetic Medicine (S.H.S.P., S.R.), Newcastle University, Newcastle upon Tyne NE1 3BZ, United Kingdom; Institute of Health and Society (M.E.Y., C.M.-R., A.K., J.C., T.B.K., C.J.), Newcastle University, Newcastle upon Tyne NE2 4AX, United Kingdom; and Department of Internal Medicine (T.J.V.), Erasmus Medical Center, Rotterdam, The Netherlands., Visser TJ; Institute of Genetic Medicine (S.H.S.P., S.R.), Newcastle University, Newcastle upon Tyne NE1 3BZ, United Kingdom; Institute of Health and Society (M.E.Y., C.M.-R., A.K., J.C., T.B.K., C.J.), Newcastle University, Newcastle upon Tyne NE2 4AX, United Kingdom; and Department of Internal Medicine (T.J.V.), Erasmus Medical Center, Rotterdam, The Netherlands., Kirkwood TB; Institute of Genetic Medicine (S.H.S.P., S.R.), Newcastle University, Newcastle upon Tyne NE1 3BZ, United Kingdom; Institute of Health and Society (M.E.Y., C.M.-R., A.K., J.C., T.B.K., C.J.), Newcastle University, Newcastle upon Tyne NE2 4AX, United Kingdom; and Department of Internal Medicine (T.J.V.), Erasmus Medical Center, Rotterdam, The Netherlands., Jagger C; Institute of Genetic Medicine (S.H.S.P., S.R.), Newcastle University, Newcastle upon Tyne NE1 3BZ, United Kingdom; Institute of Health and Society (M.E.Y., C.M.-R., A.K., J.C., T.B.K., C.J.), Newcastle University, Newcastle upon Tyne NE2 4AX, United Kingdom; and Department of Internal Medicine (T.J.V.), Erasmus Medical Center, Rotterdam, The Netherlands.

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