Výsledky vyhledávání - "Kirkwood, Thomas Bl"

Akademický článek

Aggregation, impaired degradation and immunization targeting of amyloid-beta dimers in Alzheimer’s disease: a stochastic modelling approach

Autor: Proctor Carole J, Pienaar Ilse, Elson Joanna L, Kirkwood Thomas BL

Publikováno v: Molecular Neurodegeneration, Vol 7, Iss 1, p 32 (2012)

Abstract Background Alzheimer’s disease (AD) is the most frequently diagnosed neurodegenerative disorder affecting humans, with advanced age being the most prominent risk factor for developing AD. Despite intense research efforts aimed at elucidati

Externí odkaz: https://doaj.org/article/49209523d77e44f3a11a343619214f34

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Akademický článek

A modified and automated version of the 'Fluorimetric Detection of Alkaline DNA Unwinding' method to quantify formation and repair of DNA strand breaks

Autor: Müller Marcus, Leake Alan, Sindlinger Thilo, Pfeiffer Ragen, Moreno-Villanueva María, Kirkwood Thomas BL, Bürkle Alexander

Publikováno v: BMC Biotechnology, Vol 9, Iss 1, p 39 (2009)

Abstract Background Formation and repair of DNA single-strand breaks are important parameters in the assessment of DNA damage and repair occurring in live cells. The 'Fluorimetric Detection of Alkaline DNA Unwinding (FADU)' method [Birnboim HC, Jevca

Externí odkaz: https://doaj.org/article/9cc8a707b9d7431e8f20ac9cf3e52992

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Akademický článek

A mathematical model of aging-related and cortisol induced hippocampal dysfunction

Autor: Jones Janette JL, Wilkinson Darren J, Kirkwood Thomas BL, Kenny Rose, McAuley Mark T, Miller Veronica M

Publikováno v: BMC Neuroscience, Vol 10, Iss 1, p 26 (2009)

Abstract Background The hippocampus is essential for declarative memory synthesis and is a core pathological substrate for Alzheimer's disease (AD), the most common aging-related dementing disease. Acute increases in plasma cortisol are associated wi

Externí odkaz: https://doaj.org/article/a727cff4543a4dffa51b5fde111fbc5b

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Akademický článek

Ten commandments for the future of ageing research in the UK: a vision for action

Autor: Catt Michael, Goodwin James, Powell Jonathan R, Kirkwood Thomas BL, Franco Oscar H, Ordovas Jose M, van der Ouderaa Frans

Publikováno v: BMC Geriatrics, Vol 7, Iss 1, p 10 (2007)

Abstract Increases in longevity resulting from improvements in health care and living conditions together with a decrease in fertility rates have contributed to a shift towards an aged population profile. For the first time the UK has more people ove

Externí odkaz: https://doaj.org/article/9a4a2a881b2e4e1bbd7950b7f3a83839

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