UNC2025, a MERTK Small-Molecule Inhibitor, Is Therapeutically Effective Alone and in Combination with Methotrexate in Leukemia Models.

Autor: DeRyckere D; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia.; Department of Pediatrics, Emory University, Atlanta, Georgia., Lee-Sherick AB; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado., Huey MG; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia.; Department of Pediatrics, Emory University, Atlanta, Georgia., Hill AA; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado., Tyner JW; Department of Cell, Developmental and Cancer Biology, Oregon Health and Science University, Knight Cancer Institute, Portland, Oregon., Jacobsen KM; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia.; Department of Pediatrics, Emory University, Atlanta, Georgia.; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado., Page LS; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado., Kirkpatrick GG; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado., Eryildiz F; Institute of Environmental Health and Division of Environmental and Biomolecular Systems, Oregon Health and Science University, Portland, Oregon., Montgomery SA; Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina.; Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina., Zhang W; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina School of Medicine, Chapel Hill, North Carolina., Wang X; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina School of Medicine, Chapel Hill, North Carolina., Frye SV; Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina.; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina School of Medicine, Chapel Hill, North Carolina., Earp HS; Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina.; Departments of Medicine and Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina., Graham DK; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia. Douglas.Graham@choa.org.; Department of Pediatrics, Emory University, Atlanta, Georgia.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2017 Mar 15; Vol. 23 (6), pp. 1481-1492. Date of Electronic Publication: 2016 Sep 20.