Výsledky vyhledávání

Akademický článek

Pure estrogen receptor antagonists potentiate capecitabine activity in ESR1-mutant breast cancer

Autor: Albert Grinshpun, Douglas Russo, Wen Ma, Ana Verma, Francisco Hermida-Prado, Shira Sherman, Giorgio Gaglia, Sheheryar Kabraji, Gregory Kirkner, Melissa E. Hughes, Nancy U. Lin, Zachary Sandusky, Agostina Nardone, Cristina Guarducci, Quang-De Nguyen, Sandro Santagata, Zsuzsanna Nagy, Rinath Jeselsohn

Publikováno v: npj Breast Cancer, Vol 10, Iss 1, Pp 1-12 (2024)

Abstract The ESR1 ligand binding domain activating mutations are the most prevalent genetic mechanism of acquired endocrine resistance in metastatic hormone receptor-positive breast cancer. These mutations confer endocrine resistance that remains est

Externí odkaz: https://doaj.org/article/7c7a103652a4404eac1f649798184d56

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Akademický článek

Helping ourselves, helping others: the Young Women’s Breast Cancer Study (YWS) – a multisite prospective cohort study to advance the understanding of breast cancer diagnosed in women aged 40 years and younger

Autor: Lidia Schapira, Yue Zheng, Laura Collins, Ann H Partridge, Jeffrey Peppercorn, Virginia F Borges, Rulla M Tamimi, Gregory J Kirkner, Eric P Winer, Kathryn Ruddy, Shoshana M Rosenberg, Philip D Poorvu, Craig Snow, Meghan E Meyer, Steven Come, Ellen Warner, Shari Gelber

Publikováno v: BMJ Open, Vol 14, Iss 6 (2024)

Purpose Compared with older women diagnosed with breast cancer, younger women are more likely to die of breast cancer and more likely to suffer psychosocially in both the short-term and long term. The Young Women’s Breast Cancer Study (YWS) is a mu

Externí odkaz: https://doaj.org/article/f524706438004f91987fdbc6e69b0465

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Akademický článek

Comprehensive genomic characterization of HER2-low and HER2-0 breast cancer

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)

Abstract The molecular underpinnings of HER2-low and HER2-0 (IHC 0) breast tumors remain poorly defined. Using genomic findings from 1039 patients with HER2-negative metastatic breast cancer undergoing next-generation sequencing from 7/2013-12/2020,

Externí odkaz: https://doaj.org/article/5c5258c1093e4d42ab2f76c5fe3ba511

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