Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Kirkegaard, Julius B."'
Spatial information from cell-surface receptors is crucial for processes that require signal processing and sensing of the environment. Here, we investigate the optimal placement of such receptors through a theoretical model that minimizes uncertaint
Externí odkaz:
http://arxiv.org/abs/2410.03395
Single-cell organisms and various cell types use a range of motility modes when following a chemical gradient, but it is unclear which mode is best suited for different gradients. Here, we model directional decision-making in chemotactic amoeboid cel
Externí odkaz:
http://arxiv.org/abs/2409.09342
Autor:
Alonso, Albert, Kirkegaard, Julius B.
Publikováno v:
PNAS Nexus, 2024; pgae235
We investigate the boundary between chemotaxis driven by spatial estimation of gradients and chemotaxis driven by temporal estimation. While it is well known that spatial chemotaxis becomes disadvantageous for small organisms at high noise levels, it
Externí odkaz:
http://arxiv.org/abs/2310.10531
Autor:
Alonso, Albert, Kirkegaard, Julius B.
Publikováno v:
Nature Communications Biology, 6 (2023) 754
Computer-aided analysis of biological microscopy data has seen a massive improvement with the utilization of general-purpose deep learning techniques. Yet, in microscopy studies of multi-organism systems, the problem of collision and overlap remains
Externí odkaz:
http://arxiv.org/abs/2301.04460
Autor:
Kirkegaard, Julius B., Sneppen, Kim
Publikováno v:
Physical Review E 106.5 (2022): 054409
Exploiting the mathematical curiosity of intransitive dice, we present a simple theoretical model for co-evolution that captures scales ranging from the genome of the individual to the system-wide emergence of species diversity. We study a set of evo
Externí odkaz:
http://arxiv.org/abs/2212.00374
Autor:
Kirkegaard, Julius B., Sneppen, Kim
Publikováno v:
Phys. Rev. Lett. 124, 208101 (2020)
Network flows often exhibit a hierarchical tree-like structure that can be attributed to the minimisation of dissipation. The common feature of such systems is a single source and multiple sinks (or vice versa). In contrast, here we study networks wi
Externí odkaz:
http://arxiv.org/abs/1910.14411
The experimental actualisation of organoids modelling organs from brains to pancreases has revealed that much of the diverse morphologies of organs are emergent properties of simple intercellular "rules" and not the result of top-down orchestration.
Externí odkaz:
http://arxiv.org/abs/1910.01949
Publikováno v:
In Biophysical Journal 20 June 2023 122(12):2421-2429
One of simplest examples of navigation found in nature is run-and-tumble chemotaxis. Tumbles reorient cells randomly, and cells can drift toward attractants or away from repellents by biasing the frequency of these events. The post-tumble swimming di
Externí odkaz:
http://arxiv.org/abs/1709.04375
Autor:
Haas, Pierre A., Höhn, Stephanie S. M. H., Honerkamp-Smith, Aurelia R., Kirkegaard, Julius B., Goldstein, Raymond E.
Many embryonic deformations during development are the global result of local cell shape changes and other local active cell sheet deformations. Morphogenesis does not only therefore rely on the ability of the tissue to produce these active deformati
Externí odkaz:
http://arxiv.org/abs/1708.07765