Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Kirkby, NS"'
Publikováno v:
The FASEB Journal
Regular consumption of low-dose aspirin reduces the occurrence of colorectal, esophageal, stomach, and gastrointestinal cancers. The underlying mechanism is unknown but may be linked to inhibition of angiogenesis. Because the effective doses of aspir
Autor:
Chan, MV, Knowles, RB, Lundberg, MH, Tucker, AT, Mohamed, NA, Kirkby, NS, Armstrong, PC, Mitchell, JA, Warner, TD
Publikováno v:
British Journal of Clinical Pharmacology
Aims In vivo platelet function is a product of intrinsic platelet reactivity, modifiable by dual antiplatelet therapy (DAPT), and the extrinsic inhibitory endothelial mediators, nitric oxide (NO) and prostacyclin (PGI2), that are powerfully potentiat
Autor:
Mitchell, J, Kirkby, NS
Eicosanoids represent a diverse family of lipid mediators with fundamental roles in controlling physiology and disease. Within the eicosanoid super family are prostanoids, which are specifically derived from arachidonic acid by the enzyme cyclooxygen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::f53ebaf2809f813f3cba6d0fbbb4e001
http://hdl.handle.net/10044/1/57233
http://hdl.handle.net/10044/1/57233
Autor:
Kirkby, NS, Sampaio, W, Etelvino, G, Alves, D, Anders, KL, Temponi, R, Shala, F, Nair, AS, Ahmetaj-Shala, B, Jiao, J, Herschman, HR, Xiaomeng, W, Wahli, W, Santos, RA, Mitchell, JA
Cyclooxygenase-2 (COX-2) is an inducible enzyme expressed in inflammation and cancer targeted by nonsteroidal anti-inflammatory drugs. COX-2 is also expressed constitutively in discreet locations where its inhibition drives gastrointestinal and cardi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::b5b968e42d43bb271f6902206ec1a903
http://hdl.handle.net/10044/1/54538
http://hdl.handle.net/10044/1/54538
Autor:
Miller, E, Czopek, A, Duthie, KM, Kirkby, NS, van de Putte, EEF, Christen, S, Kimmitt, RA, Moorhouse, R, Castellan, RFP, Kotelevtsev, YV, Kuc, RE, Davenport, AP, Dhaun, N, Webb, DJ, Hadoke, PWF
Publikováno v:
Miller, E, Czopek, A, Duthie, K M, Kirkby, N S, van de Putte, E E F, Christen, S, Kimmitt, R A, Moorhouse, R, Castellan, R F P, Kotelevtsev, Y V, Kuc, R E, Davenport, A P, Dhaun, N, Webb, D J & Hadoke, P W F 2017, ' Smooth Muscle Endothelin B Receptors Regulate Blood Pressure but Not Vascular Function or Neointimal Remodeling ', Hypertension, vol. 69, no. 2, pp. 275-285 . https://doi.org/10.1161/HYPERTENSIONAHA.115.07031
The role of smooth muscle endothelin$_{B}$ (ET$_{B}$) receptors in regulating vascular function, blood pressure (BP), and neointimal remodeling has not been established. Selective knockout mice were generated to address the hypothesis that loss of sm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f06fd22aaba9878c33219d3db00641e1
IL - 1 β release is integral to the innate immune system. The release of mature IL - 1 β depends on two regulated events; (i) the de novo induction of pro - IL - 1 β , generally via NF κ B - depend ent transduction pathways and (ii) the assembly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::36c577fc417d058304ee3703841b1877
http://hdl.handle.net/10044/1/44393
http://hdl.handle.net/10044/1/44393
Autor:
Willeit, P, Zampetaki, A, Kaudewitz, D, Lee, R, Dudek, K, King, A, Kirkby, NS, Markus, HS, Warner, TD, Kiechl, S, Morton, AC, Channon, K, Storey, RF, Mayr, M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b0356fdfc305ae476f1d1fbc6504ee60
https://doi.org/10.1136/heartjnl-2013-304019.265
https://doi.org/10.1136/heartjnl-2013-304019.265
BACKGROUND AND PURPOSE: Endothelin (ET) receptor antagonism reduces neointimal lesion formation in animal models. This investigation addressed the hypothesis that the selective ETA receptor antagonist sitaxentan would be more effective than mixed ETA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::f5306611cc5d15ad4c6e398e76615cb3
http://hdl.handle.net/10044/1/40905
http://hdl.handle.net/10044/1/40905
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98165 (2014)
Cyxlo-oxygenase (COX)-2 inhibitors, including traditional nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with increased cardiovascular side effects, including myocardial infarction. We and others have shown that COX-1 and not COX-2 driv
Publikováno v:
Heart; May2012, Vol. 98 Issue 9, p679-680, 2p