Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Kirk Ways"'
Autor:
Yin Liang, Kenji Arakawa, Kiichiro Ueta, Yasuaki Matsushita, Chiaki Kuriyama, Tonya Martin, Fuyong Du, Yi Liu, June Xu, Bruce Conway, Jamie Conway, David Polidori, Kirk Ways, Keith Demarest
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30555 (2012)
BACKGROUND: Canagliflozin is a sodium glucose co-transporter (SGLT) 2 inhibitor in clinical development for the treatment of type 2 diabetes mellitus (T2DM). METHODS: (14)C-alpha-methylglucoside uptake in Chinese hamster ovary-K cells expressing huma
Externí odkaz:
https://doaj.org/article/df414787d96e4b259c141d5ae76d36f9
Autor:
Kirk Ways, Gary Meininger, Greg Fulcher, Wayne Shaw, Dick de Zeeuw, George Capuano, David R. Matthews, Kenneth W. Mahaffey, Maria Alba, Vlado Perkovic, Joel Jiang, Bruce Neal, Frank Vercruysse, Mehul Desai
Publikováno v:
Diabetes Care, 38(3), 403-411. AMER DIABETES ASSOC
OBJECTIVE There are limited data about the effects of sodium–glucose cotransporter 2 inhibitors when used with insulin. We report the efficacy and safety of canagliflozin in patients with type 2 diabetes using insulin. RESEARCH DESIGN AND METHODS T
Publikováno v:
Toxicologic Pathology. 43:48-56
Canagliflozin, a sodium glucose co-transporter 2 (SGLT2) inhibitor, has been developed for the treatment of adults with type 2 diabetes mellitus (T2DM). During the phase 3 program, treatment-related pheochromocytomas, renal tubular tumors, and testic
Autor:
Bianca Feyen, Sandra De Jonghe, Calvert Louden, Petra Vinken, Stewart Bryant, Godelieve Lammens, Rao N.V.S. Mamidi, Sandra Snook, Mark D. Johnson, Esther Moesen, Michael F. Kelley, Jim Proctor, Kirk Ways, Jing Ying Ma
Publikováno v:
Chemico-Biological Interactions. 221:109-118
Canagliflozin is an SGLT2 inhibitor used for the treatment of type 2 diabetes mellitus. Studies were conducted to investigate the mechanism responsible for renal tubular tumors and pheochromocytomas observed at the high dose in a 2-year carcinogenici
Autor:
Wayne Shaw, Maria Alba, Sue Sha, Norm Rosenthal, Rong Qiu, Kirk Ways, William Canovatchel, Mehul Desai, Robert Edwards, Paul Rothenberg, Nicholas A. Di Prospero, Gary Meininger, Dainius Balis, Keith T. Demarest, Scott Bull, Frank Vercruysse, David Polidori
Publikováno v:
Annals of the New York Academy of Sciences. 1358
The sodium glucose co-transporter 2 (SGLT2) inhibitor canagliflozin is a novel treatment option for adults with type 2 diabetes mellitus (T2DM). In patients with hyperglycemia, SGLT2 inhibition lowers plasma glucose levels by reducing the renal thres
Publikováno v:
Diabetes care. 38(9)
OBJECTIVE This study assessed the incidence of serious adverse events of diabetic ketoacidosis (DKA) among patients with type 2 diabetes treated with canagliflozin. RESEARCH DESIGN AND METHODS All serious adverse events of DKA and related events (ket
Publikováno v:
Diabetes Care. 27:2363-2368
OBJECTIVE—Insulin glulisine is a novel analog of human insulin designed for use as a rapid-acting insulin. This study compared the safety and efficacy of glulisine with regular human insulin (RHI) in combination with NPH insulin. RESEARCH DESIGN AN
Autor:
Paul Nyirjesy, Cristiana Mayer, George Capuano, Kirk Ways, Keith Usiskin, Albert Fung, Jack D. Sobel
Publikováno v:
Current medical research and opinion. 30(6)
To characterize genital mycotic infections with canagliflozin, a sodium glucose co-transporter 2 inhibitor, in patients with type 2 diabetes mellitus (T2DM) using pooled data from Phase 3 studies.Genital mycotic infections with canagliflozin 100 and
Autor:
Anna Faragó, D. Kirk Ways, Gyöngyi Farkas, Szabolcs Sipeki, Erzsébet Bander, Annamária Gujdár
Publikováno v:
Cellular Signalling. 12:549-555
HGF and phorbol ester induce the scattering of HepG2 cells. Recently, we have reported that the motility and morphological responses that accompany this process require the activation of Erk1/Erk2 MAP kinases, and phosphatidylinositol 3-kinase contri
Autor:
Anna Faragó, Erzsébet Bander, Szabolcs Sipeki, László Buday, D. Kirk Ways, E. Bácsy, Gyöngyi Farkas
Publikováno v:
Cellular Signalling. 11:885-890
MAP kinase cascade-dependent responses were investigated during scattering of HepG2 human hepatoma cells stimulated by HGF or phorbol ester. Inhibition of phosphatidylinositol 3-kinase with LY294002 prevented completely the dissociation of cells. Inh