Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Kirk R. Thomas"'
Autor:
Weiquan Zhu, Murugappan Ramanathan, Anuj Tharakan, Nyall R. London, Andrew P. Lane, Kirk R. Thomas, Amy Smith, Shannon J. Odelberg
Publikováno v:
Ear, Nose & Throat Journal. 101:1S-7S
Background: ARF nucleotide-binding site opener (ARNO) is a guanine nucleotide-exchange factor for ADP-ribosylation factor proteins. ARF nucleotide-binding site opener also binds MyD88, and small-molecule inhibition of ARNO reduces inflammation in ani
Autor:
Christopher C Gibson, Chadwick T Davis, Weiquan Zhu, Jay A Bowman-Kirigin, Ashley E Walker, Zhengfu Tai, Kirk R Thomas, Anthony J Donato, Lisa A Lesniewski, Dean Y Li
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140370 (2015)
Vitamin D is a known modulator of inflammation. Native dietary vitamin D3 is thought to be bio-inactive, and beneficial vitamin D3 effects are thought to be largely mediated by the metabolite 1,25(OH)2D3. Reduced serum levels of the most commonly mea
Externí odkaz:
https://doaj.org/article/e8790ceb20744644be7a87d0c72576e4
Autor:
Zhonglou Sun, Helong Zhao, Daniel Fang, Chadwick T. Davis, Dallas S. Shi, Kachon Lei, Bianca E. Rich, Jacob M. Winter, Li Guo, Lise K. Sorensen, Robert J. Pryor, Nina Zhu, Samuel Lu, Laura L. Dickey, Daniel J. Doty, Zongzhong Tong, Kirk R. Thomas, Alan L. Mueller, Allie H. Grossmann, Baowei Zhang, Thomas E. Lane, Robert S. Fujinami, Shannon J. Odelberg, Weiquan Zhu
Publikováno v:
Neuron. 110:3106-3120.e7
Breakdown of the blood-central nervous system barrier (BCNSB) is a hallmark of many neuroinflammatory disorders, such as multiple sclerosis (MS). Using a mouse model of MS, experimental autoimmune encephalomyelitis (EAE), we show that endothelial-to-
Autor:
Nyall R, London, Anuj, Tharakan, Amy, Smith, Kirk R, Thomas, Weiquan, Zhu, Shannon J, Odelberg, Murugappan, Ramanathan, Andrew P, Lane
Publikováno v:
Ear, nose,throat journal. 101(2_suppl)
ARF nucleotide-binding site opener (ARNO) is a guanine nucleotide-exchange factor for ADP-ribosylation factor proteins. ARF nucleotide-binding site opener also binds MyD88, and small-molecule inhibition of ARNO reduces inflammation in animal models o
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e67841 (2013)
The transcription factor TBX3 plays critical roles in development and TBX3 mutations in humans cause Ulnar-mammary syndrome. Efforts to understand how altered TBX3 dosage and function disrupt the development of numerous structures have been hampered
Externí odkaz:
https://doaj.org/article/961d5a3a701f45c48bc5c7022bfd16fb
Autor:
Yolanda T. Chong, Vlad Rodic, Fiona L. Weathersby, Carl A. Brooks, Michael F. Cuccarese, Nathan H. Lazar, Ian K. Quigley, Christopher C. Gibson, Ronald W. Alfa, Berton A. Earnshaw, Kirk R. Thomas, Michael A. Statnick, Brandon L. Probst, Ben Fogelson, Nicholas D. Campbell, Jes Ford, Kathleen-Rose Skelly, Mason L. Victors, Seth W. Glazier, Peter F. McLean, James D. Jensen, Imran S. Haque, Anne E. Carpenter, Sharath S. Hegde, Chadwick T. Davis, Katie Heiser, Pamela Jacobson, Brandon M. Mendivil, Adeline S. Low, Joseph Carpenter, Elissa D. Pastuzyn, Hannah B. Gordon
Development of accurate disease models and discovery of immune-modulating drugs is challenged by the immune system’s highly interconnected and context-dependent nature. Here we apply deep-learning-driven analysis of cellular morphology to develop a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9c21782616d4199bcf88ffc3650d4b4
https://doi.org/10.1101/2020.08.02.233064
https://doi.org/10.1101/2020.08.02.233064
Autor:
Ki Moon Park, Jing Ling, Zhen Li, Claudio J. Villanueva, Jee-Yin Ahn, Ui Jeong Yun, Dean Y. Li, Seo Hyuk Chang, Jae Hyuk Yoo, No Joon Song, Kirk R. Thomas, Kye Won Park, Byung Hyun Jang, Jung Hoon Yoon, Jin Hee Choi, Vanja Panic, Sunghwan Kim, Jin Mo Ku, Suji Kim
Publikováno v:
Cell Death and Disease, Vol 9, Iss 9, Pp 1-13 (2018)
Cell Death & Disease
Cell Death & Disease
Stimulation of white adipose tissue (WAT) browning is considered as a potential approach to treat obesity and metabolic diseases. Our previous studies have shown that phytochemical butein can stimulate WAT browning through induction of Prdm4 in adipo
Autor:
Heidi A. Trau, Jena L. Chojnowski, Kirk R. Thomas, Nancy R. Manley, Mario R. Capecchi, Kyoko Masuda
Publikováno v:
Development. 141:3697-3708
Hoxa3 was the first Hox gene to be mutated by gene targeting in mice and is required for the development of multiple endoderm and neural crest cell (NCC)-derived structures in the pharyngeal region. Previous studies have shown that the Hoxa3 null mut
Publikováno v:
Circulation Research. 109:770-774
Rationale: Netrin-4 regulates vascular development. Identity of netrin-4 endothelial receptor and its subsequent cell functions is controversial. We previously demonstrated that the inhibition of netrin-1 canonical receptors, Unc5B and neogenin, expr
Publikováno v:
Blood. 115:5418-5426
Netrin-4, a laminin-related secreted protein is an axon guidance cue recently shown essential outside of the nervous system, regulating mammary and lung morphogenesis as well as blood vascular development. Here, we show that Netrin-4, at physiologic