Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Kirk R. Maples"'
Autor:
Vittorio A. Sauro, Chetan Pandit, Yong Kang Zhang, Kirk R. Maples, Stephen J. Baker, Rajeshwar Singh, Stephen J. Benkovic, Jacob J. Plattner, Ving J. Lee, Tsutomu Akama, Maureen Kully, Jehangir Khan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:5963-5967
A series of borinic acid picolinate esters were synthesized and screened for their minimum inhibitory concentration (MIC) against Gram-positive and -negative bacteria. Our lead compounds were then screened for anti-inflammatory activity. From these s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac577ce49f3bc9d5953f7dae5587b0c0
https://doi.org/10.1016/j.bmcl.2006.08.130
https://doi.org/10.1016/j.bmcl.2006.08.130
Autor:
Yong-Kang Zhang, Kirk R. Maples
Publikováno v:
Zeitschrift für Naturforschung B. 57:127-132
N-[tert-13C]Butyl C-phenyl nitrone (PBN-[tert-13C]) has been synthesized for an EPR spin trapping competition study. The newly synthesized PBN-[tert-13C] shows different 13C-hyperfine splitting constants (a13C) when it traps free radicals as compared
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edeb334457c045f504277d22dcb092a2
https://doi.org/10.1515/znb-2002-0116
https://doi.org/10.1515/znb-2002-0116
Publikováno v:
Brain Research. 909:46-50
Free radicals have gained wide acceptance as mediators of cerebral ischemic injury. It has previously been reported that a spin trap nitrone, alpha-phenyl-N-tert-butyl nitrone (PBN), can reduce infarct volumes in rats subjected to either permanent or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ca3d93ff59b3b98271c424cb46f633
https://doi.org/10.1016/s0006-8993(01)02618-x
https://doi.org/10.1016/s0006-8993(01)02618-x
Autor:
Morris B. Snipes, I.Y. Chang, Yung-Sung Cheng, Kirk R. Maples, Edward B. Barr, Janet M. Benson, Christopher H. Kennedy, Fletcher F. Hahn
Publikováno v:
Fundamental and Applied Toxicology. 28:232-244
Particle Clearance and Histopathology in Lungs of F344/N Rats and B6C3F1 Mice Inhaling Nickel Oxide or Nickel Sulfate. Benson, J. M., Chang, I.-Y., Cheng, Y.-S., Hahn F. F., Kennedy, C. H., Barr, E. B., Maples, K. R., and Snipes M. B. (1995). Fundam.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac948b8dab335454fb89c634feee694
https://doi.org/10.1006/faat.1995.1164
https://doi.org/10.1006/faat.1995.1164
Autor:
JANET M. BENSON, I-YIIN CHANG, YUNG SUNG CHENG, FLETCHER F. HAHN, CHRISTOPHER H. KENNEDY, EDWARD B. BARR, KIRK R. MAPLES, MORRIS B. SNIPES
Publikováno v:
Toxicological Sciences. 28:232-244
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::998816d9e8d75813465994119770a99c
https://doi.org/10.1093/toxsci/28.2.232
https://doi.org/10.1093/toxsci/28.2.232
Autor:
William E. Eastin, William E. Bechtold, Kirk R. Maples, Janet M. Benson, June K. Dunnick, Christopher H. Kennedy, Edward B. Barr, Yung-Sung Cheng, Charles H. Hobbs
Publikováno v:
Inhalation Toxicology. 6:167-183
The fates of inhaled nickel oxide (NiO, green oxide calcined at 1200°C) and nickel subsulfide (Ni3S2), two occupationally relevant nickel compounds, have been studied in male F344/N rats. Groups of rats underwent pernasal exposure to 9.9 mg NiO/m3 o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53c9085ebbd07fe88bbffc976e981134
https://doi.org/10.3109/08958379409029703
https://doi.org/10.3109/08958379409029703
There is ample mounting evidence that reactive oxidant species are exacerbated in inflammatory processes, many pathological conditions and underlying processes of chronic age-related diseases. Therefore there is increased expectation that therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f9beaa78505064d9b7f9aeac9f9a490
https://europepmc.org/articles/PMC3156308/
https://europepmc.org/articles/PMC3156308/
Autor:
Alan R. Dahl, Kirk R. Maples
Publikováno v:
Inhalation Toxicology. 5:43-54
We previously reported that propylene oxide levels in the blood of rats exposed to propylene spiked 5–10 min into the exposure and that hepatic and nasal cytochrome P-450 concentrations decreased relative to control values after the occurrence of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67a609f27db91586674c6b55eb6e255f
https://doi.org/10.3109/08958379309034493
https://doi.org/10.3109/08958379309034493
Autor:
Kirk R. Maples, Gregory L. Finch, William C. Griffith, Kristen J. Nikula, Bean T. Chen, Jack R. Harkema
Publikováno v:
Inhalation Toxicology. 5:389-401
Endogenous antioxidants, like the tripeptide glutathione (CSH), protect the respiratory airways from potentially injurious agents within inhaled pollutants like cigarette smoke. The purpose of this study was to determine the effects of cigarette smok
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c46fc5f411018ad8470e43944d4691ee
https://doi.org/10.3109/08958379308998394
https://doi.org/10.3109/08958379308998394
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 31:469-475
Epoxides are known mutagenic and carcinogenic metabolites of alkenes. During current toxicological investigations in our laboratory, we have monitored in vivo epoxide levels using gas chromatography/mass spectroscopy isotope dilution assays. These as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b197eb32712f7872f2e03cfec5d38162
https://doi.org/10.1002/jlcr.2580310607
https://doi.org/10.1002/jlcr.2580310607