Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Kirk R. Henne"'
Autor:
Annie Arguello, René Meisner, Elliot R. Thomsen, Hoang N. Nguyen, Ritesh Ravi, Jeffrey Simms, Iris Lo, Jessica Speckart, Julia Holtzman, Thomas M. Gill, Darren Chan, Yuhsiang Cheng, Chi-Lu Chiu, Jason C. Dugas, Meng Fang, Isabel A. Lopez, Hilda Solanoy, Buyankhishig Tsogtbaatar, Yuda Zhu, Akhil Bhalla, Kirk R. Henne, Anastasia G. Henry, Anthony Delucchi, Simona Costanzo, Jeffrey M. Harris, Dolores Diaz, Kimberly Scearce-Levie, Pascal E. Sanchez
Publikováno v:
JCI Insight, Vol 6, Iss 19 (2021)
Mucopolysaccharidosis type II (MPS II) is a lysosomal storage disorder caused by deficiency of the iduronate-2-sulfatase (IDS) enzyme, resulting in cellular accumulation of glycosaminoglycans (GAGs) throughout the body. Treatment of MPS II remains a
Externí odkaz:
https://doaj.org/article/7257efca6a4647a28c441e395328432c
Autor:
Junhua Wang, Akhil Bhalla, Julie C. Ullman, Meng Fang, Ritesh Ravi, Annie Arguello, Elliot Thomsen, Buyankhishig Tsogtbaatar, Jing L. Guo, Lukas L. Skuja, Jason C. Dugas, Sonnet S. Davis, Suresh B. Poda, Kannan Gunasekaran, Simona Costanzo, Zachary K. Sweeney, Anastasia G. Henry, Jeffrey M. Harris, Kirk R. Henne, Giuseppe Astarita
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 15, p 5449 (2020)
We recently developed a blood–brain barrier (BBB)-penetrating enzyme transport vehicle (ETV) fused to the lysosomal enzyme iduronate 2-sulfatase (ETV:IDS) and demonstrated its ability to reduce glycosaminoglycan (GAG) accumulation in the brains of
Externí odkaz:
https://doaj.org/article/8377888f3d43421b9fd6c2f9c0d4b08f
Molecular architecture determines brain delivery of a transferrin receptor–targeted lysosomal enzyme
Autor:
Annie Arguello, Cathal S. Mahon, Meredith E.K. Calvert, Darren Chan, Jason C. Dugas, Michelle E. Pizzo, Elliot R. Thomsen, Roni Chau, Lorna A. Damo, Joseph Duque, Meng Fang, Tina Giese, Do Jin Kim, Nicholas Liang, Hoang N. Nguyen, Hilda Solanoy, Buyankhishig Tsogtbaatar, Julie C. Ullman, Junhua Wang, Mark S. Dennis, Dolores Diaz, Kannan Gunasekaran, Kirk R. Henne, Joseph W. Lewcock, Pascal E. Sanchez, Matthew D. Troyer, Jeffrey M. Harris, Kimberly Scearce-Levie, Lu Shan, Ryan J. Watts, Robert G. Thorne, Anastasia G. Henry, Mihalis S. Kariolis
Publikováno v:
Journal of Experimental Medicine. 219
Delivery of biotherapeutics across the blood–brain barrier (BBB) is a challenge. Many approaches fuse biotherapeutics to platforms that bind the transferrin receptor (TfR), a brain endothelial cell target, to facilitate receptor-mediated transcytos
Autor:
Ryan J. Watts, Kathryn M. Monroe, Junhua Wang, Melina Lenser, Jennifer Hsiao-Nakamoto, Hoang Nguyen, Todd P. Logan, Do Jin Kim, Fen Huang, Ritesh Ravi, Gilbert Di Paolo, Anil Rana, Kannan Gunasekaran, Yaneth Robles-Colmenares, Gerald M. Cherf, Buyankhishig Tsogtbaatar, Ceyda Llapashtica, Kirk R. Henne, Hilda Solanoy, Pascal E. Sanchez, Yashas Rajendra, Mihalis Kariolis, Ray Lieh Yoon Low, Roni Chau, Laralynne Przybyla, Michelle E. Pizzo, Chi-Lu Chiu, Meng Fang, Anastasia G. Henry, Giuseppe Astarita, Mark S. Dennis, Adam L. Boxer, Sarah L. DeVos, Sonnet S. Davis, Hilary W. Heuer, René Meisner, Joseph W. Lewcock, Devendra B. Srivastava, Bradley F. Boeve, Meredith E. K. Calvert, Katrina W. Lexa, Rachel Prorok, Lukas L. Skuja, Dolores Diaz, Akhil Bhalla, Matthew Simon, Jung H. Suh, Ankita Srivastava, Timothy K. Earr, Howard J. Rosen, Joseph Duque, Bettina Van Lengerich, Elizabeth W. Sun
Publikováno v:
Cell
Cell, vol 184, iss 18
Cell, vol 184, iss 18
GRN mutations cause frontotemporal dementia (GRN-FTD) due to deficiency in progranulin (PGRN), a lysosomal and secreted protein with unclear function. Here, we found that Grn(−/−) mice exhibit a global deficiency in bis(monoacylglycero)phosphate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e8760616b55660b5a69ea73b7ad6da
https://europepmc.org/articles/PMC8489356/
https://europepmc.org/articles/PMC8489356/
Molecular architecture determines brain delivery of a transferrin-receptor targeted lysosomal enzyme
Autor:
Kirk R. Henne, Kimberly Scearce-Levie, Annie Arguello, Ullman Julie, Mihalis Kariolis, Tina Giese, Jeffrey M. Harris, Matthew D. Troyer, Kannan Gunasekaran, Meredith E. K. Calvert, Dolores Diaz, Anastasia G. Henry, Elliot R. Thomsen, Buyankhishig Tsogtbaatar, Roni Chau, Isabel Lopez, Joseph W. Lewcock, Cathal Mahon, Michelle E. Pizzo, Lu Shan, Darren Chan, Meng Fang, Pascal E. Sanchez, Robert G. Thorne, Timothy K. Earr, Ryan J. Watts, Joseph Duque, Lorna A. Damo, Mark S. Dennis, Hoang N. Nguyen, Do Jin Kim, Junhua Wang, Nicholas Liang, Hilda Solanoy, Jason C. Dugas
Delivery of biotherapeutics across the blood-brain barrier (BBB) is a challenge. Many approaches fuse biotherapeutics to platforms that bind the transferrin receptor (TfR), a brain endothelial cell target, to facilitate receptor-mediated transcytosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ae90ba1655eaabdb89b5f77c6a55a6f
https://doi.org/10.1101/2021.05.21.445035
https://doi.org/10.1101/2021.05.21.445035
Autor:
Hoang Nguyen, Elizabeth Sun, Yashas Rajendra, Gerald Maxwell Cherf, Jennifer Hsiao-Nakamoto, Todd P. Logan, Joseph Duque, Anil Rana, Fen Huang, Matthew J. Simon, Kannan Gunasekaran, Pascal E. Sanchez, Junhua Wang, Mihalis Kariolis, Kirk R. Henne, Zachary Kevin Sweeney, Sofia Mosesova, Sonnet S. Davis, Bettina Van Lengerich, Do Jin Kim, Hai L. Tran, Rachel Prorok, Darren Chan, Mark S. Dennis, Kathryn M. Monroe, Yuda Zhu, Ray Low, Akhil Bhalla, Gilbert Di Paolo, Ankita Srivastava, Giuseppe Astarita, Timothy K. Earr, Joseph W. Lewcock, Roni Chau, Sarah L. DeVos, Ryan J. Watts, Melina Lenser
Publikováno v:
Alzheimer's & Dementia. 16
Autor:
Sarah L. DeVos, Y. Joy Yu Zuchero, Jennifer A. Getz, Tina Giese, Michelle E. Pizzo, Meredith E. K. Calvert, Robert C. Wells, Ryan J. Watts, Mark S. Dennis, Sulochanadevi Baskaran, Takashi Miyamoto, Xiaocheng Chen, Kylie S. Chew, Yin Zhang, Raymond K. Tong, Victoria A. Assimon, Ankita Srivastava, Adam P. Silverman, Kane Lesley Ann, Sejal S. Hall, Zachary Kevin Sweeney, Catherine Bedard, Katherine Jenkins, Mihalis Kariolis, Kwan Wanda, Do Jin Kim, Robert G. Thorne, Pascal E. Sanchez, Kirk R. Henne, Hilda Solanoy, Nicholas Liang, Cathal Mahon
Publikováno v:
Science Translational Medicine. 12
Effective delivery of protein therapeutics to the central nervous system (CNS) has been greatly restricted by the blood-brain barrier (BBB). We describe the development of a BBB transport vehicle (TV) comprising an engineered Fc fragment that exploit
Autor:
Adam P. Silverman, Kwan Wanda, Junhua Wang, Alicia A. Nugent, Giuseppe Astarita, Ullman Julie, Nicholas Liang, Catherine Bedard, Sonnet S. Davis, Dolores Diaz, Gilbert Di Paolo, Anastasia G. Henry, Jennifer A. Getz, Hai L. Tran, Jason C. Dugas, Kannan Gunasekaran, Ankita Srivastava, Ryan J. Watts, Suresh Poda, Connie W.Y. Ha, Vinay M. Daryani, Sejal S. Hall, Ritesh Ravi, Michael Tuck, Thomas Sandmann, Robert C. Wells, Richard M. Caprioli, Cathal Mahon, Robert G. Thorne, Hilda Solanoy, Michelle L. Reyzer, Akhil Bhalla, Steve Lianoglou, Mihalis Kariolis, Pascal E. Sanchez, Jessica R. Blumenfeld, Timothy K. Earr, Kirk R. Henne, Hoang Nguyen, Jennifer L. Harvey, Joseph Duque, Do Jin Kim, Mark S. Dennis, Zachary Kevin Sweeney, Tina Giese, Annie Arguello
Publikováno v:
Science Translational Medicine. 12
Most lysosomal storage diseases (LSDs) involve progressive central nervous system (CNS) impairment, resulting from deficiency of a lysosomal enzyme. Treatment of neuronopathic LSDs remains a considerable challenge, as approved intravenously administe
Autor:
Catherine Bedard, Gilbert Di Paolo, Mark S. Dennis, Mihalis Kariolis, Dolores Diaz, Kirk R. Henne, Kannan Gunasekaran, Cathal Mahon, Jennifer A. Getz, Jessica R. Blumenfeld, Ryan J. Watts, Ullman Julie, Robert G. Thorne, Ankita Srivastava, Junhua Wang, Annie Arguello, Akhil Bhalla, Alicia A. Nugent, Zachary Kevin Sweeney, Giuseppe Astarita, Anastasia G. Henry, Ritesh Ravi, Adam P. Silverman, Steve Lianoglou, Tina Giese
Publikováno v:
Molecular Genetics and Metabolism. 129:S72
Autor:
Mark S. Dennis, Aimin Li, Fan Liao, Ryan J. Watts, Bradley T. Hyman, David M. Holtzman, Gilbert Gallardo, Eloise Hudry, Adam P. Silverman, Jing L. Guo, Patrick Sullivan, Monica Xiong, Grace O. Robinson, Jennifer A. Getz, Jennifer Keyser, Eli P Lerner, Zachary Kevin Sweeney, Hong Jiang, Katheryn B. Lefton, Javier Remolina Serrano, Rosa Hoyle, Nga Bien-Ly, Jason D. Ulrich, Cheryl E. G. Leyns, Kirk R. Henne, Mary Beth Finn, Yin Zhang
Publikováno v:
The Journal of clinical investigation. 128(5)
The apolipoprotein E E4 allele of the APOE gene is the strongest genetic factor for late-onset Alzheimer disease (LOAD). There is compelling evidence that apoE influences Alzheimer disease (AD) in large part by affecting amyloid β (Aβ) aggregation