Zobrazeno 1 - 10 of 210 pro vyhledávání: '"Kirk R. Gustafson"'
1
Akademický článek
Identification of natural product modulators of Merkel cell carcinoma cell growth and survival
Autor: Emily A. Smith, Natasha T. Hill, Tara Gelb, Khalid A. Garman, Ekaterina I. Goncharova, Heidi R. Bokesch, Chang-Kwon Kim, Karen L. Wendt, Robert H. Cichewicz, Kirk R. Gustafson, Isaac Brownell, Curtis J. Henrich
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Merkel cell carcinoma (MCC) is a rare, but aggressive skin cancer the incidence of which has increased significantly in recent years. The majority of MCCs have incorporated Merkel cell polyomavirus (VP-MCC) while the remainder are virus-nega
Externí odkaz: https://doaj.org/article/0ba58604b5d14bf384c1fbeb026e0be3
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2
Akademický článek
Geobarrettin D, a Rare Herbipoline-Containing 6-Bromoindole Alkaloid from Geodia barretti
Autor: Xiaxia Di, Ingibjorg Hardardottir, Jona Freysdottir, Dongdong Wang, Kirk R. Gustafson, Sesselja Omarsdottir, Tadeusz F. Molinski
Publikováno v: Molecules, Vol 28, Iss 7, p 2937 (2023)
Geobarrettin D (1), a new bromoindole alkaloid, was isolated from the marine sponge Geodia barretti collected from Icelandic waters. Its structure was elucidated by 1D, and 2D NMR (including 1H-15N HSQC, 1H-15N HMBC spectra), as well as HRESIMS data.
Externí odkaz: https://doaj.org/article/c3be15501c57479284de7b26206564c0
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3
Akademický článek
Anti-Fibrotic Potential of Tomentosenol A, a Constituent of Cerumen from the Australian Native Stingless Bee, Tetragonula carbonaria
Autor: Karina D. Hamilton, Daniel Czajkowski, Nicolas J. Kong, Trong D. Tran, Kirk R. Gustafson, Gary Pauly, Glen M. Boyle, Jacinta L. Simmons, Robert Steadman, Ryan Moseley, Peter R. Brooks, Steven M. Ogbourne, Fraser D. Russell
Publikováno v: Antioxidants, Vol 11, Iss 8, p 1604 (2022)
Bioactivity-guided fractionation was used to isolate two compounds, tomentosenol A (1) and torellianone A (2), from a cerumen extract from Tetragonula carbonaria. The anti-fibrotic activity of these compounds was examined using human cultured neonata
Externí odkaz: https://doaj.org/article/58110c04aace4746b4251c0bac3cea21
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5
Akademický článek
Roseabol A, a New Peptaibol from the Fungus Clonostachys rosea
Autor: Chang-Kwon Kim, Lauren R. H. Krumpe, Emily Smith, Curtis J. Henrich, Isaac Brownell, Karen L. Wendt, Robert H. Cichewicz, Barry R. O’Keefe, Kirk R. Gustafson
Publikováno v: Molecules, Vol 26, Iss 12, p 3594 (2021)
A new 11 amino acid linear peptide named roseabol A (1) and the known compound 13-oxo-trans-9,10-epoxy-11(E)-octadecenoic acid (2) were isolated from the fungus Clonostachys rosea. Combined NMR and MS analysis revealed that roseabol A (1) contained a
Externí odkaz: https://doaj.org/article/b7a165798502424f9cdc797706b6b936
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6
Akademický článek
Agelasine Diterpenoids and Cbl-b Inhibitory Ageliferins from the Coralline Demosponge Astrosclera willeyana
Autor: Wei Jiang, Dongdong Wang, Brice A. P. Wilson, Unwoo Kang, Heidi R. Bokesch, Emily A. Smith, Antony Wamiru, Ekaterina I. Goncharova, Donna Voeller, Stanley Lipkowitz, Barry R. O’Keefe, Kirk R. Gustafson
Publikováno v: Marine Drugs, Vol 19, Iss 7, p 361 (2021)
An extract of the coralline demosponge Astrosclera willeyana inhibited the ubiquitin ligase activity of the immunomodulatory protein Cbl-b. The bioassay-guided separation of the extract provided ten active compounds, including three new N-methyladeni
Externí odkaz: https://doaj.org/article/e88285871d6e4f548affd387fbd4536c
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8
Akademický článek
A Molecular Networking Strategy: High-Throughput Screening and Chemical Analysis of Brazilian Cerrado Plant Extracts against Cancer Cells
Autor: Patrícia C. Cortelo, Daniel P. Demarque, Renata G. Dusi, Lorena C. Albernaz, Raimundo Braz-Filho, Ekaterina I. Goncharova, Heidi R. Bokesch, Kirk R. Gustafson, John A. Beutler, Laila S. Espindola
Publikováno v: Cells, Vol 10, Iss 3, p 691 (2021)
Plants have historically been a rich source of successful anticancer drugs and chemotherapeutic agents, with research indicating that this trend will continue. In this contribution, we performed high-throughput cytotoxicity screening of 702 extracts
Externí odkaz: https://doaj.org/article/1cd6f56b1a7a4ec288871ea59af18416
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