Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Kirk R Hutchinson"'
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72080 (2013)
Cardiovascular complications are a leading cause of death in patients with type 2 diabetes mellitus (T2DM). Diastolic dysfunction is one of the earliest manifestations of diabetes-induced changes in left ventricular (LV) function, and results from a
Externí odkaz:
https://doaj.org/article/8f26effd8dcc47ef809da325212a2a03
Autor:
Markus Velten, Kirk R Hutchinson, Matthew W Gorr, Loren E Wold, Pamela A Lucchesi, Lynette K Rogers
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24544 (2011)
The impact of the neonatal environment on the development of adult cardiovascular disease is poorly understood. Systemic maternal inflammation is linked to growth retardation, preterm birth, and maturation deficits in the developing fetus. Often pret
Externí odkaz:
https://doaj.org/article/38bcab904fd0471d9cd5402f0e49233b
Publikováno v:
Circulation Research. 119:764-772
Rationale: Patients with heart failure with preserved ejection fraction (HFpEF) experience elevated filling pressures and reduced ventricular compliance. The splicing factor RNA-binding motif 20 (RBM20) regulates the contour length of titin’s sprin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f207799204a37a3f9a1e2a8fe6dff067
https://doi.org/10.1161/circresaha.116.308904
https://doi.org/10.1161/circresaha.116.308904
Autor:
Zachary Hernandez, Christine A. Henderson, José M. Valdez, Henk Granzier, Carol C. Gregorio, Rachel M. Mayfield, Kirk R. Hutchinson, Ki Hwan Nam, Cathleen Cover, Miensheng Chu, Christopher T. Pappas, Nima Jamilpour, Pak Kin Wong
Publikováno v:
Proceedings of the National Academy of Sciences. 112:13573-13578
Leiomodin 2 (Lmod2) is an actin-binding protein that has been implicated in the regulation of striated muscle thin filament assembly; its physiological function has yet to be studied. We found that knockout of Lmod2 in mice results in abnormally shor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32fdce2f27859e8e62181907ccac45ae
https://doi.org/10.1073/pnas.1508273112
https://doi.org/10.1073/pnas.1508273112
Autor:
Christopher T. Pappas, Mei Methawasin, Henk Granzier, Kirk R. Hutchinson, John E. Smith, Mathew M. Bull, Paola Tonino, Rebecca E. Slater, Frank Li, Chandra Saripalli, Carol C. Gregorio
Publikováno v:
Proceedings of the National Academy of Sciences. 111:14589-14594
Titin, the largest protein known, forms a giant filament in muscle where it spans the half sarcomere from Z disk to M band. Here we genetically targeted a stretch of 14 immunoglobulin-like and fibronectin type 3 domains that comprises the I-band/A-ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbf920629a19e389f2c7f22bb9bccbbb
https://doi.org/10.1073/pnas.1411493111
https://doi.org/10.1073/pnas.1411493111
Autor:
Siegfried Labeit, Xiuju Luo, Caiying Guo, Chandra Saripalli, Mei Methawasin, Carlos Hidalgo, Kirk R. Hutchinson, John E. Smith, Charles S. Chung, Henk Granzier
Publikováno v:
Circulation. 128:19-28
Background— Diastolic dysfunction is a poorly understood but clinically pervasive syndrome that is characterized by increased diastolic stiffness. Titin is the main determinant of cellular passive stiffness. However, the physiological role that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6373a2fd323c15771b078e513a20af4
https://doi.org/10.1161/circulationaha.112.001268
https://doi.org/10.1161/circulationaha.112.001268
Publikováno v:
Circulation Research. 119
Greater than half of all heart failure (HF) patients suffer from increased diastolic stiffness and impaired relaxation of the left ventricle while their ejection fraction (EF) is preserved (HFpEF). HFpEF is a complex disease characterized by diastoli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c24999181602952ddd9f77fd6337611
https://doi.org/10.1161/res.119.suppl_1.398
https://doi.org/10.1161/res.119.suppl_1.398
Autor:
James A. Stewart, Maarten L. Galantowicz, Kurt J. Varner, Flavia M. Souza-Smith, Aaron J. Trask, Mary J. Cismowski, Kirk R. Hutchinson, Paige S. Katz, Pamela A. Lucchesi, Kevin C Lord
Publikováno v:
Basic Research in Cardiology. 106:1123-1134
Little is known about the impact of type 2 diabetes mellitus (DM) on coronary arteriole remodeling. The aim of this study was to determine the mechanisms that underlie coronary arteriole structural remodeling in type 2 diabetic (db/db) mice. Passive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7148f394a222abba55ec7bf47c26f59
https://doi.org/10.1007/s00395-011-0201-0
https://doi.org/10.1007/s00395-011-0201-0
Publikováno v:
Circulation Research. 117
Titin, a myofilament that acts as a molecular spring in the sarcomere, is considered the main contributor to passive stiffness of cardiomyocytes and is responsible for cardiac diastolic function. Increased titin stiffness is related to diastolic dysf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c65f8270fdf00a890c6d995236e80a42
https://doi.org/10.1161/res.117.suppl_1.215
https://doi.org/10.1161/res.117.suppl_1.215
We investigated the cellular and molecular mechanisms of diastolic dysfunction in pure volume overload induced by aortocaval fistula (ACF) surgery in the mouse. Four weeks of volume overload resulted in significant biventricular hypertrophy; protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f8c5818849bf8d1584be4082574330
https://europepmc.org/articles/PMC4302034/
https://europepmc.org/articles/PMC4302034/
