Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Kirk McLean"'
Autor:
Xiao-Yan Zhao, Andreas Wilmen, Dongli Wang, Xinquan Wang, Maxine Bauzon, Ji-Yun Kim, Lars Linden, Liang Li, Ursula Egner, Tobias Marquardt, Dieter Moosmayer, Jan Tebbe, Julian Marius Glück, Philipp Ellinger, Kirk McLean, Shujun Yuan, Subramanian Yegneswaran, Xiaoqiao Jiang, Vince Evans, Jian-Ming Gu, Doug Schneider, Ying Zhu, Yifan Xu, Cornell Mallari, Ashley Hesslein, Yan Wang, Nicole Schmidt, Katrin Gutberlet, Christine Ruehl-Fehlert, Alexius Freyberger, Terry Hermiston, Chandra Patel, Derek Sim, Laurent O. Mosnier, Volker Laux
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Activated protein C (APC) is a plasma serine protease with antithrombotic and cytoprotective functions. Here, the authors develop a monoclonal antibody that specifically inhibits APC’s anticoagulant function without compromising its cytoprotective
Externí odkaz:
https://doaj.org/article/9ba7c3d64bcb4b03984dbf3b38cd94db
Autor:
Bertolt Kreft, Karl Ziegelbauer, Rolf Jautelat, Heiner Apeler, Gabriele Leder, Jan Tebbe, Sherif El Sheikh, Rudolf Beier, Frank Dittmer, Jörg Müller, Oliver von Ahsen, Joachim Schuhmacher, Kirk Mclean, Patricia E. Carrigan, Christoph Kneip, Sven Golfier, Claudia Lange, Carol Pena, Beatrix Stelte-Ludwig, Charlotte Kopitz, Hans-Georg Lerchen, Lars Linden, Jörg Willuda
Synthesis of C4.4A-ADC (A), Active metabolites resulting from intracellular degradation of C4.4A-ADC (B), Activity of the C4.4A-ADC metabolites (C), Range of drug-to-antibody ratio (D), and Purity and aggregate content of the ADC (E).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a489a13efac39deb0ca0eac729ae7941
https://doi.org/10.1158/1535-7163.22503556
https://doi.org/10.1158/1535-7163.22503556
Autor:
Bala Thangaraj, Bixente Martirene, Parag Patel, Ashely Husslein, Kirk McLean, Josh Walker, Charlie Heise, Patricia Rose, John Amara, Jon Petrone, Martin Heitmann, Qingwei Luo, Gerhard Greller, James Colley
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcf14779693e850ae68f2ef723d14322
https://doi.org/10.46220/2020tr001
https://doi.org/10.46220/2020tr001
Autor:
Chandra Patel, Julian Marius Glück, Derek Sim, Shujun Yuan, Ying Zhu, Yan Wang, Terry Hermiston, Liang Li, Cornell Mallari, Dieter Moosmayer, Christine Ruehl-Fehlert, Xiaoqiao Jiang, Xiao-Yan Zhao, Katrin Gutberlet, Xinquan Wang, Dongli Wang, Laurent O. Mosnier, Jan Tebbe, Ashley Hesslein, Vince Evans, Yifan Xu, Subramanian Yegneswaran, Nicole Schmidt, Lars Linden, Andreas Wilmen, Kirk Mclean, Jian-Ming Gu, Tobias Marquardt, Doug Schneider, Ursula Egner, Philipp Ellinger, Volker Laux, Ji-Yun Kim, Alexius Freyberger, Maxine Bauzon
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Activated protein C (APC) is a plasma serine protease with antithrombotic and cytoprotective functions. Based on the hypothesis that specific inhibition of APC’s anticoagulant but not its cytoprotective activity can be beneficial for hemophilia the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb59b9c0dc462528b55e42fb2e14e4c0
http://europepmc.org/articles/PMC7293249
http://europepmc.org/articles/PMC7293249
Autor:
Heiner Apeler, Jörg Willuda, Carol Peña, Charlotte Kopitz, Sherif El Sheikh, Claudia Lange, Christoph Kneip, Sven Golfier, Jan Tebbe, Hans-Georg Lerchen, Patricia E. Carrigan, Rolf Jautelat, Gabriele Leder, Joachim Schuhmacher, Rudolf Beier, Kirk Mclean, Beatrix Stelte-Ludwig, Jörg Müller, Karl Ziegelbauer, Frank Dittmer, Oliver von Ahsen, Bertolt Kreft, Lars Linden
Publikováno v:
Molecular cancer therapeutics. 16(5)
C4.4A (LYPD3) has been identified as a cancer- and metastasis-associated internalizing cell surface protein that is expressed in non–small cell lung cancer (NSCLC), with particularly high prevalence in the squamous cell carcinoma (SCC) subtype. Wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51bbe742919c1a15738a98b4f159db21
https://pubmed.ncbi.nlm.nih.gov/28292941
https://pubmed.ncbi.nlm.nih.gov/28292941
Autor:
Tara Heitner, Douglas W. Schneider, David R. Light, Bruno Alicke, Jeongsoo Yoo, Noboru Satozawa, Renate Parry, Jason S. Lewis, Kirk Mclean, Gordon Parry
Publikováno v:
Journal of Nuclear Medicine. 50:435-443
To optimize in vivo tissue uptake kinetics and clearance of engineered monoclonal antibody (mAb) fragments for radiotherapeutic and radiodiagnostic applications, we compared the biodistribution and tumor localization of four 111In- and 86Y-labeled an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8a2b9028372507fc6edb756f511cdf
https://doi.org/10.2967/jnumed.108.055608
https://doi.org/10.2967/jnumed.108.055608
Autor:
Yi-Xin Wang, Baby Martin-McNulty, Brent Larsen, Serene Alexander, Kirk Mclean, Jon Vincelette, David R. Light, Chenliang Wu
Publikováno v:
Thrombosis and Haemostasis. 96:317-324
SummaryTissue factor (TF) exposure isa potent pro-thrombotic trigger that initiates activation of the coagulation cascade, while thrombomodulin (TM) is a potent anticoagulant protein that limits the extent of activation. Both TF neutralizing antibodi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbaf3f1263233abd7b330beb5cbbfdb1
https://doi.org/10.1160/th06-04-0219
https://doi.org/10.1160/th06-04-0219
Autor:
Chad A. Van Huis, Jeremy J. Edmunds, Kenneth J. Shaw, Marc Whitlow, Arnaiz Damian O, Marc Adler, Cuiman Cai, David R. Light, Kamlai Saiya-Cork, J. Adam Willardsen, Lakshmi Narasimhan, Erli Zhang, Stephen T. Rapundalo, Kevin J. Filipski, Wayne L. Cody, Kirk Mclean, Danette Dudley, Jeffrey T. Kohrt, Cecile McKnight, Robert J. Leadley, Yuo-Ling Chou
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4752-4756
The activated Factor VII/tissue factor complex (FVIIa/TF) plays a key role in the formation of blood clots. Inhibition of this complex may lead to new antithrombotic drugs. An X-ray crystal structure of a fluoropyridine-based FVIIa/TF inhibitor bound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2c6b0dc75cebe92a561353096bd522
https://doi.org/10.1016/j.bmcl.2005.07.059
https://doi.org/10.1016/j.bmcl.2005.07.059
Autor:
Derek Sim, Xiaoqiao Jiang, Maxine Bauzon, Charles T. Esmon, Vince Evans, Jian-Ming Gu, Subramanian Yegneswaran, Jun Xu, Xiao-Yan Zhao, Chandra Patel, Peter Bringmann, Katalin Kauser, Kirk Mclean, Inge A. Ivens, Doug Schneider, Ying Zhu
Publikováno v:
Blood. 128:80-80
In patients with hemophilia, hereditary defects in coagulation factors result in unstable clots and recurrent bleeding. Although the current standard of care focuses on replacement factor therapy, we propose that inhibition of the anticoagulant pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dd3df4807dca9980f6c520b1d9ebb5d
https://doi.org/10.1182/blood.v128.22.80.80
https://doi.org/10.1182/blood.v128.22.80.80
Modulation of glycosaminoglycan addition in naturally expressed and recombinant human thrombomodulin
Autor:
R. M. Wydro, John Morser, Jiing-Huey Lin, William H. Andrews, Kirk Mclean, Tish A. Young, David R. Light
Publikováno v:
Journal of Biological Chemistry. 269:25021-25030
The two major glycoforms of full-length human thrombomodulin (TM), one with (TM(CS+)) and one without (TM(CS-)) chondroitin sulfate (CS) were analyzed on Western blots of primary and transformed cells and in cells expressing recombinant TM. TM on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cf1f88bf29be3f675f4492e654ba9fe
https://doi.org/10.1016/s0021-9258(17)31493-x
https://doi.org/10.1016/s0021-9258(17)31493-x