Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Kirk M McHugh"'
Autor:
Dong Liang, Kirk M McHugh, Pat D Brophy, Nader Shaikh, J Robert Manak, Peter Andrews, Inessa Hakker, Zihua Wang, Andrew L Schwaderer, David S Hains
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0220617 (2019)
Vesicoureteral reflux (VUR) is a complex, heritable disorder. Genome-wide linkage analyses of families affected by VUR have revealed multiple genomic loci linked to VUR. These loci normally harbor a number of genes whose biologically functional varia
Externí odkaz:
https://doaj.org/article/abe8a36d8bb7487d9ac0f2115dde8d7d
Autor:
John David Spencer, Ashley R Jackson, Birong Li, Christina B Ching, Martin Vonau, Robert S Easterling, Andrew L Schwaderer, Kirk M McHugh, Brian Becknell
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144024 (2015)
Recent evidence indicates that antimicrobial peptides (AMPs) serve key roles in defending the urinary tract against invading uropathogens. To date, the individual contribution of AMPs to urinary tract host defense is not well defined. In this study,
Externí odkaz:
https://doaj.org/article/8848787ceb8e43d5b8331a24ec1e0f3a
Autor:
Brian Becknell, John David Spencer, Ashley R Carpenter, Xi Chen, Aspinder Singh, Suzanne Ploeger, Jennifer Kline, Patrick Ellsworth, Birong Li, Ehrhardt Proksch, Andrew L Schwaderer, David S Hains, Sheryl S Justice, Kirk M McHugh
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77714 (2013)
Beta defensins (BDs) are cationic peptides with antimicrobial activity that defend epithelial surfaces including the skin, gastrointestinal, and respiratory tracts. However, BD expression and function in the urinary tract are incompletely characteriz
Externí odkaz:
https://doaj.org/article/6d49bf21d8734f84ba9848851b6dbc51
Autor:
Brian Becknell, Ashley R Carpenter, Jordan L Allen, Michael E Wilhide, Susan E Ingraham, David S Hains, Kirk M McHugh
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e72762 (2013)
Congenital obstructive nephropathy is a common cause of chronic kidney disease and a leading indication for renal transplant in children. The cellular and molecular responses of the kidney to congenital obstruction are incompletely characterized. In
Externí odkaz:
https://doaj.org/article/e11d639e30e6499d852d288c286c2d22
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53675 (2013)
In this study, we examined the expression of Sonic Hedgehog, Patched, Gli1, Gli2, Gli3 and Myocardin in the developing bladders of male and female normal and megabladder (mgb-/-) mutant mice at embryonic days 12 through 16 by in situ hybridization. T
Externí odkaz:
https://doaj.org/article/c84c829291a34085ba969a7b66c3a187
Publikováno v:
Nat Rev Urol
Congenital anomalies of the kidney and urinary tract (CAKUTs) represent the leading cause of chronic kidney disease and end-stage kidney disease in children. Increasing evidence points to critical roles for the urothelium in the developing urinary tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a50c3211cc96c95e730d606501d65106
https://doi.org/10.1038/s41585-020-0348-2
https://doi.org/10.1038/s41585-020-0348-2
Autor:
Monica L. Hoff, Kirk M. McHugh, Birong Li, Ashley R. Jackson, Christina B. Ching, Brian Becknell
Publikováno v:
Am J Physiol Renal Physiol
Congenital urinary tract obstruction (UTO) is the leading cause of chronic kidney disease in children; however, current management strategies do not safeguard against progression to end-stage renal disease, highlighting the need for interventions to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b4d36d9420c4ab15f653b6e79d9a47
https://doi.org/10.1152/ajprenal.00171.2019
https://doi.org/10.1152/ajprenal.00171.2019
Publikováno v:
Anatomical sciences educationLITERATURE CITED. 15(1)
The profession of physical therapy has undergone an evolution since its inception. Since the early 1900s it has grown from a technical training program to a doctorate level degree. Human anatomy courses remain a requirement for physical therapist edu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41bd5a8e69d2a9d6e7eb8fc1dc305ada
https://pubmed.ncbi.nlm.nih.gov/33253489
https://pubmed.ncbi.nlm.nih.gov/33253489
Publikováno v:
Journal of Pediatric Ophthalmology & Strabismus. 57
The authors report a case of a diffuse choroidal hemangioma in the left eye of a 17-year-old girl. No evidence of leptomeningeal angiomatosis was found on magnetic resonance imaging and neither the medical history nor the clinical examination reveale
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce2d8d187ec046393a99ff88f095695e
https://doi.org/10.3928/01913913-20200512-01
https://doi.org/10.3928/01913913-20200512-01
Autor:
Christina B. Ching, Nicholas Mayne, Hanna Cortado, Ashley R. Jackson, Birong Li, Sudipti Gupta, Kirk M. McHugh, Brian Becknell
Publikováno v:
Kidney International. 93:1320-1329
The signaling networks regulating antimicrobial activity during urinary tract infection (UTI) are incompletely understood. Interleukin-6 (IL-6) levels increase with UTI severity, but the specific contributions of IL-6 to host immunity against bacteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf5a7abc99c26eb7c2aed198a08596d
https://doi.org/10.1016/j.kint.2017.12.006
https://doi.org/10.1016/j.kint.2017.12.006