Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Kirk M Habegger"'
Autor:
Chun-Xia Yi, Kristy M Heppner, Henriette Kirchner, Jenny Tong, Maximillian Bielohuby, Bruce D Gaylinn, Timo D Müller, Erin Bartley, Harold W Davis, Yongmei Zhao, Anupama Joseph, Traci Kruthaupt, Nickki Ottaway, Dhiraj Kabra, Kirk M Habegger, Stephen C Benoit, Martin Bidlingmaier, Michael O Thorner, Diego Perez-Tilve, Matthias H Tschöp, Paul T Pfluger
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32100 (2012)
OBJECTIVE:Ghrelin acylation by ghrelin O-acyltransferase (GOAT) has recently been reported to be essential for the prevention of hypoglycemia during prolonged negative energy balance. Using a unique set of four different genetic loss-of-function mode
Externí odkaz:
https://doaj.org/article/bc467b72b5ea464ba3c01bca6c8e1ed1
Autor:
Jacob D. Covert, Brian A. Grice, Matthew G. Thornburg, Manpreet Kaur, Andrew P. Ryan, Lixuan Tackett, Theja Bhamidipati, Natalie D. Stull, Teayoun Kim, Kirk M. Habegger, Donald A. McClain, Joseph T. Brozinick, Jeffrey S. Elmendorf
Publikováno v:
Molecular Metabolism, Vol 72, Iss , Pp 101715- (2023)
Objective: A buildup of skeletal muscle plasma membrane (PM) cholesterol content in mice occurs within 1 week of a Western-style high-fat diet and causes insulin resistance. The mechanism driving this cholesterol accumulation and insulin resistance i
Externí odkaz:
https://doaj.org/article/034b5171489647b9bf0aa2bbe510d46e
Autor:
Jeanne M. Clark, W. Timothy Garvey, Kevin D. Niswender, Ann Marie Schmidt, Rexford S. Ahima, Jose O. Aleman, Ashley N. Battarbee, Joshua Beckman, Wendy L. Bennett, Nancy J. Brown, Paula Chandler‐Laney, Nancy Cox, Ira J. Goldberg, Kirk M. Habegger, Lorie M. Harper, Alyssa H. Hasty, Bertha A. Hidalgo, Sangwon F. Kim, Julie L. Locher, James M. Luther, Nisa M. Maruthur, Edgar R. Miller, Mary Ann Sevick, Quinn Wells
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 4 (2023)
ABSTRACT: As the worldwide prevalence of overweight and obesity continues to rise, so too does the urgency to fully understand mediating mechanisms, to discover new targets for safe and effective therapeutic intervention, and to identify biomarkers t
Externí odkaz:
https://doaj.org/article/dfc5fe5313eb46eda04ed5b4b43b5df4
Autor:
Aijun Qiao, Junlan Zhou, Shiyue Xu, Wenxia Ma, Chan Boriboun, Teayoun Kim, Baolong Yan, Jianxin Deng, Liu Yang, Eric Zhang, Yuhua Song, Yongchao C. Ma, Stephane Richard, Chunxiang Zhang, Hongyu Qiu, Kirk M. Habegger, Jianyi Zhang, Gangjian Qin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Hepatic gluconeogenesis is important for glucose homeostasis and a therapeutic target for type 2 diabetes. Here, the authors show that the RNA-binding adaptor protein Sam68 promotes the expression level of gluconeogenic genes and increases blood gluc
Externí odkaz:
https://doaj.org/article/06ee0683d6c7406d8c7218d61e9eae37
Autor:
Jessica D. Kepple, Yanping Liu, Teayoun Kim, Cheryl Cero, James W. Johnson, Glenn C. Rowe, Aaron M. Cypess, Kirk M. Habegger, Martin Young, Chad S. Hunter
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101284- (2021)
Objective: Brown adipose tissue (BAT) is critical for thermogenesis and glucose/lipid homeostasis. Exploiting the energy uncoupling capacity of BAT may reveal targets for obesity therapies. This exploitation requires a greater understanding of the tr
Externí odkaz:
https://doaj.org/article/fa6c61723738419489af22749dacd08d
Autor:
Shelly R. Nason, Jessica Antipenko, Natalie Presedo, Stephen E. Cunningham, Tanya H. Pierre, Teayoun Kim, Jodi R. Paul, Cassie Holleman, Martin E. Young, Karen L. Gamble, Brian Finan, Richard DiMarchi, Chad S. Hunter, Alexei Kharitonenkov, Kirk M. Habegger
Publikováno v:
JCI Insight, Vol 6, Iss 4 (2021)
Glucagon regulates glucose and lipid metabolism and promotes weight loss. Thus, therapeutics stimulating glucagon receptor (GCGR) signaling are promising for obesity treatment; however, the underlying mechanism(s) have yet to be fully elucidated. We
Externí odkaz:
https://doaj.org/article/e8dcffeaedd84dd1a4aa5ab2124d4f0a
Autor:
Mark E. Pepin, Lindsey E. Padgett, Ruth E. McDowell, Ashley R. Burg, Manoja K. Brahma, Cassie Holleman, Teayoun Kim, David Crossman, Olaf Kutsch, Hubert M. Tse, Adam R. Wende, Kirk M. Habegger
Publikováno v:
Molecular Metabolism, Vol 12, Iss , Pp 48-61 (2018)
Objective: Breakthroughs in HIV treatment, especially combination antiretroviral therapy (ART), have massively reduced AIDS-associated mortality. However, ART administration amplifies the risk of non-AIDS defining illnesses including obesity, diabete
Externí odkaz:
https://doaj.org/article/fedf00fc7bf543b3ab7496c3a6c6834c
Autor:
Miguel Angel Sánchez-Garrido, Kirk M. Habegger, Christoffer Clemmensen, Cassie Holleman, Timo D. Müller, Diego Perez-Tilve, Pengyun Li, Archita S. Agrawal, Brian Finan, Daniel J. Drucker, Matthias H. Tschöp, Richard D. DiMarchi, Alexei Kharitonenkov
Publikováno v:
Molecular Metabolism, Vol 5, Iss 10, Pp 1015-1024 (2016)
Objective: Fibroblast activation protein (FAP) is a serine protease belonging to a S9B prolyl oligopeptidase subfamily. This enzyme has been implicated in cancer development and recently reported to regulate degradation of FGF21, a potent metabolic h
Externí odkaz:
https://doaj.org/article/31ad42b04719485db5d22d56c1a12086
Autor:
SHELLY NASON, TEAYOUN KIM, JESSICA P. ANTIPENKO, BRIAN FINAN, RICHARD DIMARCHI, KIRK M. HABEGGER
Publikováno v:
Diabetes. 71
Historically, glucagon is proposed to be a key factor in the development of diabetes. However, we demonstrated that while chronic glucagon receptor (GCGR) agonism induces hyperglycemia and glucose intolerance, it also improves insulin secretion and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a4cebb92492780307bf3815a89edd5a
https://doi.org/10.2337/db22-197-or
https://doi.org/10.2337/db22-197-or
Autor:
TEAYOUN KIM, SHELLY NASON, JESSICA P. ANTIPENKO, BRIAN FINAN, ANATH SHALEV, RICHARD DIMARCHI, KIRK M. HABEGGER
Publikováno v:
Diabetes. 71
Long term glucagon receptor (GCGR) agonism is associated with hyperglycemia and glucose intolerance, while acute GCGR agonism enhances whole-body insulin sensitivity and hepatic AKTSer473 phosphorylation. These divergent effects establish a critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b061f5815723608d157395e011a205d
https://doi.org/10.2337/db22-230-or
https://doi.org/10.2337/db22-230-or