Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Kirk L. Ives"'
Autor:
Kirk L. Ives, Judith F. Aronson, Clarisse D. Djukom, J. Russ Carmical, Guillermo Gomez, Thomas G. Wood, Mark R. Hellmich, Celia Chao
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology
Experimental data indicate that colorectal cancer cells with CD133 expression exhibit enhanced tumorigenicity over CD133-negative (CD133-) cells. We hypothesized that CD133-positive (CD133+) cells, compared with CD133-, are more tumorigenic because t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::322c6d516bad8935da5e7b18dc87ed71
https://doi.org/10.1038/labinvest.2011.185
https://doi.org/10.1038/labinvest.2011.185
Autor:
Hiroaki Watanabe, B. Mark Evers, L. Andy Chen, Jing Li, Yuning Zhou, Lindsey N. Jackson, Scott R. Silva, Kirk L. Ives, Mark R. Hellmich
Publikováno v:
Journal of Biological Chemistry. 284:2459-2471
The protein kinase D (PKD) family of serine/threonine kinases, which can be activated by gastrointestinal hormones, consists of three distinct isoforms that modulate a variety of cellular processes including intracellular protein transport as well as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b19907ef0b600f438d7139b09789f09d
https://doi.org/10.1074/jbc.m801697200
https://doi.org/10.1074/jbc.m801697200
Publikováno v:
Clinical Cancer Research. 12:5346-5355
Purpose: Neurotensin, a gut tridecapeptide, acts as a potent cellular mitogen for various colorectal and pancreatic cancers that possess high-affinity neurotensin receptors. Cytokine/chemokine proteins are increasingly recognized as important local f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22647a7100721f6fb506e8ec19f8e372
https://doi.org/10.1158/1078-0432.ccr-06-0968
https://doi.org/10.1158/1078-0432.ccr-06-0968
Publikováno v:
Journal of Surgical Research. 129:313-321
Background In this study, the prevalence and identity of the cells expressing functional receptors for the gastrointestinal (GI) peptide hormones: gastrin, bombesin, and neurotensin in dissociated cells from 20 freshly resected human primary colorect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc94a4be3c32c9716f737974a870b4cd
https://doi.org/10.1016/j.jss.2005.04.038
https://doi.org/10.1016/j.jss.2005.04.038
Autor:
Robert A. Davey, Elizabeth Goluszko, Kirk L. Ives, Andrey A. Kolokoltsov, Mark R. Hellmich, Courtney M. Townsend, Celia Chao
Publikováno v:
Journal of Biological Chemistry. 280:33368-33373
The third intracellular loop domain of G protein-coupled receptors regulates their desensitization, internalization, and resensitization. Colorectal and pancreatic cancers, but not the nonmalignant tissue, express a splice variant of the cholecystoki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26192f2b526d94a1e49e758c314bf55e
https://doi.org/10.1074/jbc.m506337200
https://doi.org/10.1074/jbc.m506337200
Autor:
James F. Battey, Kirk L. Ives, Pei-Wen Chen, Patrick J. Cahill, Roxanne A. Ally, Iman Eltounsi, Mark R. Hellmich, Elie Traube, Glenn S. Kroog
Publikováno v:
Molecular Pharmacology. 64:890-904
Acute desensitization of many guanine nucleotide-binding protein-coupled receptors (GPCRs) requires receptor phosphorylation and subsequent binding of an arrestin. GPCRs are substrates for phosphorylation by several classes of kinases. Gastrin-releas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac1e061c876befab673f566ab2854bbb
https://doi.org/10.1124/mol.64.4.890
https://doi.org/10.1124/mol.64.4.890
Publikováno v:
Biology of Reproduction. 66:1230-1236
Although oxytocin and its receptor have been identified in human ovary, its regulatory role in granulosa cell or corpus luteum function has not been clearly defined. To better understand oxytocin action in the human ovary, we have characterized the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d850cb9825c002a7274956c3843649e
https://doi.org/10.1095/biolreprod66.5.1230
https://doi.org/10.1095/biolreprod66.5.1230
Autor:
Melvyn S. Soloff, Kirk L. Ives, Zuzana Strakova, Yow-Jiun Jeng, Mark R. Hellmich, Daniel Liebenthal
Publikováno v:
Endocrinology. 141:4136-4145
The up-regulation of oxytocin (OT) receptors in rabbit amnion at the end of gestation is associated with a large increase in the ability of OT to stimulate PGE2 synthesis. The purpose of these investigations was to determine what other factors contri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59dc5541e83e360a22ce88d0c5d293b0
https://doi.org/10.1210/endo.141.11.7761
https://doi.org/10.1210/endo.141.11.7761
Autor:
Melvyn S. Soloff, Mark R. Hellmich, Sarasija Hoare, Yow Jiun Jeng, Kirk L. Ives, Zuzana Strakova, John A. Copland
Publikováno v:
Journal of Biological Chemistry. 274:28682-28689
As the oxytocin receptor plays a key role in parturition and lactation, there is considerable interest in defining its structure/functional relationships. We previously showed that the rat oxytocin receptor transfected into Chinese hamster ovary cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54b5ded18710440499ee73b3eac4bc9b
https://doi.org/10.1074/jbc.274.40.28682
https://doi.org/10.1074/jbc.274.40.28682
Autor:
Mark R. Hellmich, Courtney M. Townsend, George H. Greeley, Melvyn S. Soloff, Kirk L. Ives, Burgess N. Christensen, Vidyavathi Udupi
Publikováno v:
Journal of Biological Chemistry. 274:23901-23909
Gastrin-releasing peptide (GRP) and its amphibian homolog, bombesin, are potent secretogogues in mammals. We determined the roles of intracellular free Ca(2+) ([Ca(2+)](i)), protein kinase C (PKC), and mitogen-activated protein kinases (MAPK) in GRP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf405bb695a8735a9f3f07cf83a95caa
https://doi.org/10.1074/jbc.274.34.23901
https://doi.org/10.1074/jbc.274.34.23901