Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Kirk J McManus"'
Autor:
Signe Penner-Goeke, Zelda Lichtensztejn, Megan Neufeld, Jennifer L Ali, Alon D Altman, Mark W Nachtigal, Kirk J McManus
Publikováno v:
PLoS Genetics, Vol 13, Iss 4, p e1006707 (2017)
Epithelial ovarian cancer (EOC) is the most prevalent form of ovarian cancer and has the highest mortality rate. Novel insight into EOC is required to minimize the morbidity and mortality rates caused by recurrent, drug resistant disease. Although nu
Externí odkaz:
https://doaj.org/article/a0a1febf6f9a4b2bb667638173e688dc
Autor:
Lucile M-P Jeusset, Kirk J McManus
Publikováno v:
Cells, Vol 8, Iss 2, p 165 (2019)
Histone ubiquitination is a critical epigenetic mechanism regulating DNA-driven processes such as gene transcription and DNA damage repair. Importantly, the cellular machinery regulating histone ubiquitination is frequently altered in cancers. Moreov
Externí odkaz:
https://doaj.org/article/b5c7671e97b14e579013e1789ae8f5f4
Autor:
Laura L Thompson, Kirk J McManus
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123200 (2015)
Chromosome instability (CIN) is characterized by a progressive change in chromosome numbers. It is a characteristic common to virtually all tumor types, and is commonly observed in highly aggressive and drug resistant tumors. Despite this information
Externí odkaz:
https://doaj.org/article/611ef10afaca4924b28fd057c6fb1d12
Autor:
Jessica C Price, Lana M Pollock, Meghan L Rudd, Sarah K Fogoros, Hassan Mohamed, Christin L Hanigan, Matthieu Le Gallo, NIH Intramural Sequencing Center (NISC) Comparative Sequencing Program, Suiyuan Zhang, Pedro Cruz, Praveen F Cherukuri, Nancy F Hansen, Kirk J McManus, Andrew K Godwin, Dennis C Sgroi, James C Mullikin, Maria J Merino, Philip Hieter, Daphne W Bell
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e63313 (2014)
Most endometrial cancers can be classified histologically as endometrioid, serous, or clear cell. Non-endometrioid endometrial cancers (NEECs; serous and clear cell) are the most clinically aggressive of the three major histotypes and are characteriz
Externí odkaz:
https://doaj.org/article/3e6912cd2b044f93a13ec39d39f4d8c9
Autor:
Derek M van Pel, Irene J Barrett, Yoko Shimizu, Babu V Sajesh, Brent J Guppy, Tom Pfeifer, Kirk J McManus, Philip Hieter
Publikováno v:
PLoS Genetics, Vol 9, Iss 1, p e1003254 (2013)
Harnessing genetic differences between cancerous and noncancerous cells offers a strategy for the development of new therapies. Extrapolating from yeast genetic interaction data, we used cultured human cells and siRNA to construct and evaluate a synt
Externí odkaz:
https://doaj.org/article/7008e5b95da64f1da627f0bb212a729a
Autor:
Daphne W Bell, Nilabja Sikdar, Kyoo-Young Lee, Jessica C Price, Raghunath Chatterjee, Hee-Dong Park, Jennifer Fox, Masamichi Ishiai, Meghan L Rudd, Lana M Pollock, Sarah K Fogoros, Hassan Mohamed, Christin L Hanigan, NISC Comparative Sequencing Program, Suiyuan Zhang, Pedro Cruz, Gabriel Renaud, Nancy F Hansen, Praveen F Cherukuri, Bhavesh Borate, Kirk J McManus, Jan Stoepel, Payal Sipahimalani, Andrew K Godwin, Dennis C Sgroi, Maria J Merino, Gene Elliot, Abdel Elkahloun, Charles Vinson, Minoru Takata, James C Mullikin, Tyra G Wolfsberg, Philip Hieter, Dae-Sik Lim, Kyungjae Myung
Publikováno v:
PLoS Genetics, Vol 7, Iss 8, p e1002245 (2011)
ATAD5, the human ortholog of yeast Elg1, plays a role in PCNA deubiquitination. Since PCNA modification is important to regulate DNA damage bypass, ATAD5 may be important for suppression of genomic instability in mammals in vivo. To test this hypothe
Externí odkaz:
https://doaj.org/article/f77e2c0ad98744ec84cad927ff742253
Development and validation of a prognostic 15-gene signature for stratifying HER2+/ER+ breast cancer
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 2940-2949 (2023)
Background: Human epidermal growth receptor 2-positive (HER2+) breast cancer (BC) is a heterogeneous subgroup. Estrogen receptor (ER) status is emerging as a predictive marker within HER2+ BCs, with the HER2+/ER+ cases usually having better survival
Externí odkaz:
https://doaj.org/article/6158a5833f5544c2ae30439be64a9518
Autor:
Kelcey Winchar, Pascal Lambert, Kirk J. McManus, Bernie Chodirker, Sarah Kean, Kim Serfas, Kathleen Decker, Mark W. Nachtigal, Alon D. Altman
Publikováno v:
Current Oncology, Vol 29, Iss 12, Pp 9365-9376 (2022)
(1) Background: The primary objective of this study was to examine the rate of genetic referral, BRCA testing, and BRCA positivity amongst all patients with high-grade serous ovarian cancers (HGSOC) from 2004–2019. The secondary objective was to an
Externí odkaz:
https://doaj.org/article/87167dc5edf64399bbd50c4464f0103c
Autor:
Lucas E. L. Terceiro, Nnamdi M. Ikeogu, Matheus F. Lima, Chidalu A. Edechi, Barbara E. Nickel, Gabor Fischer, Etienne Leygue, Kirk J. McManus, Yvonne Myal
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 12034 (2023)
Breast cancer (BC) is the most common cancer in women, with metastatic BC being responsible for the highest number of deaths. A frequent site for BC metastasis is the brain. Brain metastasis derived from BC involves the cooperation of multiple geneti
Externí odkaz:
https://doaj.org/article/7f0e9555eb244de6b32cfd6e03fed370
Publikováno v:
Cancers, Vol 15, Iss 6, p 1735 (2023)
Colorectal cancer (CRC) is one of the most lethal cancers worldwide, accounting for nearly ~10% of all cancer diagnoses and deaths. Current therapeutic approaches have considerably increased survival for patients diagnosed at early stages; however, ~
Externí odkaz:
https://doaj.org/article/62e7e69a427147deb034cd3eba7d5a1f