Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Kirk J Lubick"'
Autor:
Zhigang Yi, Lindsey Sperzel, Cindy Nürnberger, Peter J Bredenbeek, Kirk J Lubick, Sonja M Best, Cristina T Stoyanov, Lok Man J Law, Zhenghong Yuan, Charles M Rice, Margaret R MacDonald
Publikováno v:
PLoS Pathogens, Vol 7, Iss 1, p e1001255 (2011)
Viruses in the Flavivirus genus of the Flaviviridae family are arthropod-transmitted and contribute to staggering numbers of human infections and significant deaths annually across the globe. To identify cellular factors with antiviral activity again
Externí odkaz:
https://doaj.org/article/bff01d06ed4c4506a6daef1243d5de93
Autor:
Thomas G. Brewer, Kirk J. Lubick, Adaeze O. Izuogu, Saurabh Chattopadhyay, Saad Alqahtani, Kristin L. McNally, John B. Presloid, Sonja M. Best, Xiche Hu, Brian H. Youseff, R. Travis Taylor
Publikováno v:
iScience, Vol 15, Iss, Pp 489-501 (2019)
iScience
iScience
Summary Tick-borne flaviviruses (TBFVs) can cause life-threatening encephalitis and hemorrhagic fever. To identify virus-host interactions that may be exploited as therapeutic targets, we analyzed the TBFV polyprotein in silico for antiviral protein-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48409536fe03ef4bac110c4cdd361fc1
http://www.sciencedirect.com/science/article/pii/S2589004219301476
http://www.sciencedirect.com/science/article/pii/S2589004219301476
Autor:
R. Travis Taylor, Kirk J. Lubick, Vanessa M. Hirsch, Jeremy Luban, Vanessa R. Montoya, Abhilash I. Chiramel, Fadila Bouamr, Omayra Méndez-Solís, Vinod Nair, Nicholas R. Meyerson, Sara L. Sawyer, Gail L. Sturdevant, Brian H. Youseff, Sonja M. Best, Kyusik Kim, Shelly J. Robertson, Kristin L. McNally, Robin M. Ireland, Catharine M. Bosio, Rebecca M. Broeckel
Publikováno v:
Cell Reports, Vol 27, Iss 11, Pp 3269-3283.e6 (2019)
Cell reports
Cell reports
SUMMARY Tripartite motif-containing protein 5α (TRIM5α) is a cellular antiviral restriction factor that prevents early events in retrovirus replication. The activity of TRIM5α is thought to be limited to retroviruses as a result of highly specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc9ae36b08db33f516538c5f610770b9
https://doi.org/10.1101/605345
https://doi.org/10.1101/605345
Autor:
Niranjan B. Butchi, Sonja M. Best, Karin E. Peterson, Timothy M. Morgan, David G. Baker, R. Travis Taylor, Piyali Mukherjee, Tyson A. Woods, Kirk J. Lubick, Piyanate Sunyakumthorn
Publikováno v:
Journal of General Virology. 94:336-347
Toll-like receptor 7 (TLR7) recognizes guanidine-rich viral ssRNA and is an important mediator of peripheral immune responses to several ssRNA viruses. However, the role that TLR7 plays in regulating the innate immune response to ssRNA virus infectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e4f6706c3cd0b3b00596da2aca93d11
https://doi.org/10.1099/vir.0.043984-0
https://doi.org/10.1099/vir.0.043984-0
Autor:
Sonja M. Best, Adolfo García-Sastre, Marshall E. Bloom, Michael R. Holbrook, Maudry Laurent-Rolle, Joseph Ashour, Alan D.T. Barrett, W. Lesley Shupert, Alexander A. Khromykh, Peter W. Mason, Elena F. Boer, Kirk J. Lubick, Wen Jun Liu, Barry Rockx, James B. Wolfinbarger, Aaron B. Carmody
Publikováno v:
Journal of Virology. 84:3503-3515
Flaviviruses transmitted by arthropods represent a tremendous disease burden for humans, causing millions of infections annually. All vector-borne flaviviruses studied to date suppress host innate responses to infection by inhibiting alpha/beta inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0545cebac10bf1419f9ef7c159052159
https://doi.org/10.1128/jvi.01161-09
https://doi.org/10.1128/jvi.01161-09
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 192(6)
Tick-borne encephalitis virus (TBEV), a member of the Flaviviridae family, is a leading cause of viral encephalitis in Europe and Asia. Dendritic cells (DCs), as early cellular targets of infection, provide an opportunity for flaviviruses to inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e67fc97622499fc513aee6bf85101a
https://pubmed.ncbi.nlm.nih.gov/24532583
https://pubmed.ncbi.nlm.nih.gov/24532583
Autor:
Charles M. Rice, Zhigang Yi, Cindy Nürnberger, Lindsey Sperzel, Peter J. Bredenbeek, Margaret R. MacDonald, Cristina Stoyanov, Lok Man J. Law, Kirk J. Lubick, Sonja M. Best, Zhenghong Yuan
Publikováno v:
PLoS Pathogens, 7(1)
PLoS Pathogens, Vol 7, Iss 1, p e1001255 (2011)
PLoS Pathogens
PLoS Pathogens, Vol 7, Iss 1, p e1001255 (2011)
PLoS Pathogens
Viruses in the Flavivirus genus of the Flaviviridae family are arthropod-transmitted and contribute to staggering numbers of human infections and significant deaths annually across the globe. To identify cellular factors with antiviral activity again
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f49682f2ad8806230f4538a435caa88
http://hdl.handle.net/1887/109123
http://hdl.handle.net/1887/109123
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 174(10)
Gammadelta T cells recognize unprocessed or non-peptide Ags, respond rapidly to infection, and localize to mucosal surfaces. We have hypothesized that the innate functions of gammadelta T cells may be more similar to those of cells of the myeloid lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4d83290abc472fdc9448467e0c03a1e2
https://pubmed.ncbi.nlm.nih.gov/15879098
https://pubmed.ncbi.nlm.nih.gov/15879098
Publikováno v:
Cytokine. 52:70-71
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d0bd14c8c85cc5667d0aa693249f956
https://doi.org/10.1016/j.cyto.2010.07.297
https://doi.org/10.1016/j.cyto.2010.07.297
Autor:
Kirk J. Lubick, Avram D. Walts, Mariko Ishizuka, Alexandra F. Freeman, Conrad B. Addison, Richard Green, Manfred Boehm, Kentaro Yoshii, Michael G. Katze, Sonja M. Best, Erin C. Foster, Abhilash I. Chiramel, Kristin L. McNally, Steven M. Holland, R. Travis Taylor, Seitaro Tsuruda, Mizuki Sakai, Daniel L. Kastner, Angela L. Rasmussen, Shelly J. Robertson, Brett A. Freedman, Antonella Forlino, Elena F. Boer
Publikováno v:
Cell Host & Microbe. (1):61-74
SummaryType I interferon (IFN-α/β or IFN-I) signals through two receptor subunits, IFNAR1 and IFNAR2, to orchestrate sterile and infectious immunity. Cellular pathways that regulate IFNAR1 are often targeted by viruses to suppress the antiviral eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd443d3b006ebae53419a2846341e52