Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Kirk J, McManus"'
Development and validation of a prognostic 15-gene signature for stratifying HER2+/ER+ breast cancer
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 2940-2949 (2023)
Background: Human epidermal growth receptor 2-positive (HER2+) breast cancer (BC) is a heterogeneous subgroup. Estrogen receptor (ER) status is emerging as a predictive marker within HER2+ BCs, with the HER2+/ER+ cases usually having better survival
Externí odkaz:
https://doaj.org/article/6158a5833f5544c2ae30439be64a9518
Autor:
Kelcey Winchar, Pascal Lambert, Kirk J. McManus, Bernie Chodirker, Sarah Kean, Kim Serfas, Kathleen Decker, Mark W. Nachtigal, Alon D. Altman
Publikováno v:
Current Oncology, Vol 29, Iss 12, Pp 9365-9376 (2022)
(1) Background: The primary objective of this study was to examine the rate of genetic referral, BRCA testing, and BRCA positivity amongst all patients with high-grade serous ovarian cancers (HGSOC) from 2004–2019. The secondary objective was to an
Externí odkaz:
https://doaj.org/article/87167dc5edf64399bbd50c4464f0103c
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The S-phase Kinase-Associated Protein 1 (SKP1) is a core component of the SKP1, Cullin 1, F-box protein (SCF) complex, an E3 ubiquitin ligase that serves to poly-ubiquitinate a vast array of protein targets as a signal for their proteasomal degradati
Externí odkaz:
https://doaj.org/article/93c0f3d9987d4039aede7c679ca45ae6
Autor:
Judith C. Hugh, Lacey S.J. Haddon, John Maringa Githaka, Gilbert Bigras, Xiuying Hu, Brittney Madden, John Hanson, Zsolt Gabos, Nadia V. Giannakopoulos, Fleur Huang, Mary M. Hitt, Kirk J. McManus, David Olson, Kelly Dabbs, John R. Mackey
Publikováno v:
Heliyon, Vol 8, Iss 1, Pp e08666- (2022)
Estrogen is thought to cause proliferation of all estrogen receptor positive (ER+) breast cancers. Paradoxically, in the Women's Health Initiative Trial, estrogen-only hormone replacement therapy reduced the incidence and mortality of low grade, ER+,
Externí odkaz:
https://doaj.org/article/02a9a9bf2a5f4ecbada80d2d235591c4
Publikováno v:
Cells, Vol 11, Iss 23, p 3731 (2022)
Despite the high morbidity and mortality rates associated with colorectal cancer (CRC), the underlying molecular mechanisms driving CRC development remain largely uncharacterized. Chromosome instability (CIN), or ongoing changes in chromosome complem
Externí odkaz:
https://doaj.org/article/3db5246b1ed3446794043a6074faec09
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 9, Pp 943-950 (2018)
There are a substantial portion of colorectal cancers (CRCs), termed interval CRCs (I-CRCs), that are diagnosed shortly after a negative colonoscopy (i.e., no detectable polyps or CRC) and before recommended follow-up screening. The underlying cause(
Externí odkaz:
https://doaj.org/article/3c6bb56b7340449eb01d229aa8c41444
Autor:
Selina Casalino, Sharon Bruce, Kim Serfas, Alon D. Altman, Sarah Kean, Pascal Lambert, Kirk J. McManus, Jessica N. Hartley, Mark W. Nachtigal
Publikováno v:
Journal of Genetic Counseling.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d20ce5f3dfbe52757a16d0a5d0f8a5a
https://doi.org/10.1002/jgc4.1684
https://doi.org/10.1002/jgc4.1684
Publikováno v:
Cells, Vol 9, Iss 2, p 344 (2020)
Micronuclei are small, extranuclear bodies that are distinct from the primary cell nucleus. Micronucleus formation is an aberrant event that suggests a history of genotoxic stress or chromosome mis-segregation events. Accordingly, assays evaluating m
Externí odkaz:
https://doaj.org/article/a210463b21fe46608e7963e8b4d83520
Autor:
Ally C. Farrell, Zelda Lichtensztejn, Kirk J. McManus, Michaela C. L. Palmer, Tooba Razi, Nicole M. Neudorf
Publikováno v:
Human Molecular Genetics. 31:1471-1486
Despite the high morbidity and mortality rates associated with colorectal cancer (CRC), the aberrant genes and mechanisms driving CRC pathogenesis remain poorly understood. Chromosome instability (CIN), or ongoing changes in chromosome numbers, is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7109d3d5c667b6a8d37d6f46b59e5f0f
https://doi.org/10.1093/hmg/ddab330
https://doi.org/10.1093/hmg/ddab330
Autor:
Signe Penner-Goeke, Zelda Lichtensztejn, Megan Neufeld, Jennifer L Ali, Alon D Altman, Mark W Nachtigal, Kirk J McManus
Publikováno v:
PLoS Genetics, Vol 13, Iss 4, p e1006707 (2017)
Epithelial ovarian cancer (EOC) is the most prevalent form of ovarian cancer and has the highest mortality rate. Novel insight into EOC is required to minimize the morbidity and mortality rates caused by recurrent, drug resistant disease. Although nu
Externí odkaz:
https://doaj.org/article/a0a1febf6f9a4b2bb667638173e688dc