Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Kirk G, Hines"'
Publikováno v:
Biophysical Journal. 122:973-983
We monitored the effect on function of the G-protein-coupled receptor (GPCR) rhodopsin from small, stepwise changes in bilayer thickness induced by cholesterol. Over a range of phosphatidylcholine bilayers with hydrophobic thickness from ≈21 Å to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03616dc610be814a18455532b14aeaab
https://doi.org/10.1016/j.bpj.2022.11.2937
https://doi.org/10.1016/j.bpj.2022.11.2937
Autor:
Grace H. Taumoefolau, Henry L. Puhl, Kirk G. Hines, Tuan A. Nguyen, Eefei Chen, Robert B. Best, Steven S. Vogel
Publikováno v:
Biophysical Journal. 122:546a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0356c194b17528ac48d7006133879d4d
https://doi.org/10.1016/j.bpj.2022.11.2889
https://doi.org/10.1016/j.bpj.2022.11.2889
Publikováno v:
Journal of Biological Chemistry. 295:181-190
G protein–coupled receptors (GPCRs) comprise a large class of integral membrane proteins involved in the regulation of a broad spectrum of physiological processes and are a major target for pharmaceutical drug development. Structural studies can he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81d70eabcc1676ca82a76fd4c119e2b8
https://doi.org/10.1074/jbc.ra119.010696
https://doi.org/10.1074/jbc.ra119.010696
Site-selective labeling and electron paramagnetic resonance studies of human cannabinoid receptor CB
Autor:
Alexei A, Yeliseev, Kaeli, Zoretich, Levi, Hooper, Walter, Teague, Lioudmila, Zoubak, Kirk G, Hines, Klaus, Gawrisch
Publikováno v:
Biochim Biophys Acta Biomembr
Integral membrane G protein-coupled receptors (GPCR) regulate multiple physiological processes by transmitting signals from extracellular milieu to intracellular proteins and are major targets of pharmaceutical drug development. Since GPCR are inhere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b290bb7397640f44abcaeb0fdca99a7c
https://pubmed.ncbi.nlm.nih.gov/33865808
https://pubmed.ncbi.nlm.nih.gov/33865808
Autor:
Kyle Williston, Alexei Yeliseev, Arjen van den Berg, Lioudmila Zoubak, Wanhua Yan, Sam Stepnowski, Jonathan Zmuda, Kirk G. Hines, Klaus Gawrisch
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Rational design of pharmaceutical drugs targeting integral membrane G protein-coupled receptors (GPCR) requires thorough understanding of ligand binding and mechanism of activation through high resolution structural studies of purified proteins. Due
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b8b674b0b8fcceacee23134e4437d26
https://doi.org/10.1038/s41598-020-73813-7
https://doi.org/10.1038/s41598-020-73813-7
Autor:
Alexei Yeliseev, Kaeli Zoretich, Levi Hooper, Walter E. Teague, Lioudmila Zoubak, Kirk G. Hines, Klaus Gawrisch
Publikováno v:
Biophysical Journal. 121:85a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a62614303de172a6c293be6309c7310b
https://doi.org/10.1016/j.bpj.2021.11.2287
https://doi.org/10.1016/j.bpj.2021.11.2287
Autor:
Kirk G. Hines, Alexei Yeliseev, Klaus Gawrisch, Walter E. Teague, Levi Hooper, Lioudmila Zoubak, Kaeli Zoretich
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1863:183621
Integral membrane G protein-coupled receptors (GPCR) regulate multiple physiological processes by transmitting signals from extracellular milieu to intracellular proteins and are major targets of pharmaceutical drug development. Since GPCR are inhere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50709cea5f8e9a3ae630e27e3fc9ad3e
https://doi.org/10.1016/j.bbamem.2021.183621
https://doi.org/10.1016/j.bbamem.2021.183621
Publikováno v:
J Biol Chem
G protein–coupled receptors (GPCRs) comprise a large class of integral membrane proteins involved in the regulation of a broad spectrum of physiological processes and are a major target for pharmaceutical drug development. Structural studies can he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e5a7f40a305bf826c8d7260207d4bf98
https://pubmed.ncbi.nlm.nih.gov/31776188
https://pubmed.ncbi.nlm.nih.gov/31776188
Autor:
Jonathan D. Nickels, Klaus Gawrisch, Dow P. Hurst, John Katsaras, Kirk G. Hines, Diane L. Lynch, Lioudmila Zoubak, Kevin L. Weiss, Alexei Yeliseev, Walter E. Teague, Patricia H. Reggio
Publikováno v:
Biophysical Journal. 116:234a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::065e4c89014904a8c84021c5f4a2d0be
https://doi.org/10.1016/j.bpj.2018.11.1288
https://doi.org/10.1016/j.bpj.2018.11.1288
Autor:
Kirk G. Hines, Horia I. Petrache, Walter E. Teague, Klaus Gawrisch, R. Peter Rand, Olivier Soubias, Nola Fuller
Publikováno v:
Faraday Discuss.. 161:383-395
Membranes with a high content of polyunsaturated phosphatidylethanolamines (PE) facilitate formation of metarhodopsin-II (M(II)), the photointermediate of bovine rhodopsin that activates the G protein transducin. We determined whether M(II)-formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bd8b6a7a5c73c4393b43c85b57e8671
https://doi.org/10.1039/c2fd20095c
https://doi.org/10.1039/c2fd20095c