Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Kirk E Hevener"'
Autor:
Hyun Lee, Tian Zhu, Kavankumar Patel, Yan-Yan Zhang, Lena Truong, Kirk E Hevener, Joseph L Gatuz, Gitanjali Subramanya, Hyun-Young Jeong, Susan L Uprichard, Michael E Johnson
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e75144 (2013)
Development of drug-resistant mutations has been a major problem with all currently developed Hepatitis C Virus (HCV) NS3/4A inhibitors, including the two FDA approved drugs, significantly reducing the efficacy of these inhibitors. The high incidence
Externí odkaz:
https://doaj.org/article/865643715fb8455293491e77012d45c1
Autor:
Abiola O. Olaitan, Chetna Dureja, Madison A. Youngblom, Madeline A. Topf, Wan-Jou Shen, Anne J. Gonzales-Luna, Aditi Deshpande, Kirk E. Hevener, Jane Freeman, Mark H. Wilcox, Kelli L. Palmer, Kevin W. Garey, Caitlin S. Pepperell, Julian G. Hurdle
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Severe outbreaks and deaths have been linked to the emergence and global spread of fluoroquinolone-resistant Clostridioides difficile over the past two decades. At the same time, metronidazole, a nitro-containing antibiotic, has shown decrea
Externí odkaz:
https://doaj.org/article/424d815f462b4e1c9fe133cfb7dbf801
Autor:
Mingming Zhang, Allan M. Prior, Marcus M. Maddox, Wan-Jou Shen, Kirk E. Hevener, David F. Bruhn, Robin B. Lee, Aman P. Singh, Justin Reinicke, Charles J. Simmons, Julian G. Hurdle, Richard E. Lee, Dianqing Sun
Publikováno v:
ACS Omega, Vol 3, Iss 12, Pp 18343-18360 (2018)
Externí odkaz:
https://doaj.org/article/27abe659138b4f32a2e630d0506d1f8f
Autor:
Arturo Luna-Tapia, Christian DeJarnette, Emily Sansevere, Parker Reitler, Arielle Butts, Kirk E. Hevener, Glen E. Palmer
Publikováno v:
mSphere, Vol 4, Iss 1 (2019)
ABSTRACT Calcium is a critically important secondary messenger of intracellular signal transduction in eukaryotes but must be maintained at low levels in the cytoplasm of resting cells to avoid toxicity. This is achieved by several pumps that activel
Externí odkaz:
https://doaj.org/article/6096f121cb3f41459643d166be2241b7
Autor:
Abiola O. Olaitan, Chetna Dureja, Madison A. Youngblom, Madeline A. Topf, Wan-Jou Shen, Anne J. Gonzales-Luna, Aditi Deshpande, Kirk E. Hevener, Jane Freeman, Mark H. Wilcox, Kelli L. Palmer, Kevin W. Garey, Caitlin S. Pepperell, Julian G. Hurdle
Severe outbreaks and deaths have been linked to the emergence and global spread of fluoroquinolone-resistant Clostridioides difficile over the past two decades. At the same time, metronidazole, a nitro-containing antibiotic, has shown decreasing clin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5f1ada71740c933e215be5afe7e5271
https://doi.org/10.1101/2022.09.23.509282
https://doi.org/10.1101/2022.09.23.509282
Autor:
Krissada Norseeda, Fahad Bin Aziz Pavel, Jacob T. Rutherford, Humna N. Meer, Chetna Dureja, Julian G. Hurdle, Kirk E. Hevener, Dianqing Sun
Publikováno v:
Bioorganic & Medicinal Chemistry. :117330
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec3c33e9836947bb1bafe7cf5cf96ee2
https://doi.org/10.1016/j.bmc.2023.117330
https://doi.org/10.1016/j.bmc.2023.117330
Autor:
Kirk E. Hevener, Brian M. Peters, Kristiana A Avad, Jian Miao, Rand A Al-Waqfi, David J. Lowes
Publikováno v:
ACS Infectious Diseases. 7:2522-2535
Invasive and superficial infections caused by the Candida species result in significant global morbidity and mortality. As the pathogenicity of these organisms is intimately intertwined with host immune response, therapies to target both the fungus a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c568afd701532128a839a6c0700f324b
https://doi.org/10.1021/acsinfecdis.1c00270
https://doi.org/10.1021/acsinfecdis.1c00270
Autor:
Elizabeth C. Griffith, Nicole A. Vita, Ekaterina Gavrish, Autumn Brown Gandt, Alex K Mugengana, Lei Yang, Richard E. Lee, Kirk E. Hevener, Lalit Kumar Sharma, George Agyapong, Michael D. LaFleur, Jiuyu Liu, Kevin Moran
Publikováno v:
ACS Infectious Diseases. 7:1044-1058
The successful treatment of Helicobacter pylori infections is becoming increasingly difficult due to the rise of resistance against current broad spectrum triple therapy regimens. In the search for narrow-spectrum agents against H. pylori, a high-thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::153a66473f8a4397db6037501de34da3
https://doi.org/10.1021/acsinfecdis.0c00300
https://doi.org/10.1021/acsinfecdis.0c00300
Autor:
Katsuhiko Mitachi, David Mingle, Wendy Effah, Antonio Sánchez‐Ruiz, Kirk E. Hevener, Ramesh Narayanan, William M. Clemons, Francisco Sarabia, Michio Kurosu
Publikováno v:
Angewandte Chemie (International ed. in English). 61(31)
A short total synthesis of tunicamycin V (1), a non-selective phosphotransferase inhibitor, is achieved via a Büchner–Curtius–Schlotterbeck type reaction. Tunicamycin V can be synthesized in 15 chemical steps from D-galactal with 21 % overall yi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c425a9fb61d5fac4afb138e48f990c90
https://pubmed.ncbi.nlm.nih.gov/35594368
https://pubmed.ncbi.nlm.nih.gov/35594368
Autor:
Hyun Lee, Shahila Mehboob, Kirk E. Hevener, Bernard D. Santarsiero, Jesse A. Jones, Teuta Boci, Michael E. Johnson
Enoyl-acyl carrier protein (ACP) reductase II (FabK) is a critical rate-limiting enzyme in the bacterial type II fatty-acid synthesis (FAS II) pathway. FAS II pathway enzymes are markedly disparate from their mammalian analogs in the FAS I pathway in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8adfbfbdb3246761b0b94600938d0a9b