Výsledky vyhledávání - "Kirk D. Kozminski"

Contribution of Extrahepatic Aldehyde Oxidase Activity to Human Clearance

Autor: Kirk D. Kozminski, Jangir Selimkhanov, Michael A. Zientek, Scott Heyward

Publikováno v: Drug Metabolism and Disposition. 49:743-749

Aldehyde oxidase (AOX) is a soluble, cytosolic enzyme that metabolizes various N-heterocyclic compounds and organic aldehydes. It has wide tissue distribution with highest levels found in liver, kidney, and lung. Human clearance projections of AOX su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8372e76dd589c38ff1018c77b0f34a0d
https://doi.org/10.1124/dmd.120.000313

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Predictive In Vitro-In Vivo Extrapolation for Time Dependent Inhibition of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and CYP2D6 Using Pooled Human Hepatocytes, Human Liver Microsomes, and a Simple Mechanistic Static Model

Autor: Diane Ramsden, J. George Zhang, Cody L Fullenwider, Elke S Perloff, Thuy Ho, Kirk D. Kozminski, Andrea Whitcher-Johnstone, Reena Patel

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 50(2)

Inactivation of Cytochrome P450 (CYP450) enzymes can lead to significant increases in exposure of co-medicants. The majority of reported in vitro to in vivo extrapolation (IVIVE) data have historically focused on CYP3A4 leaving the assessment of othe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7711fd1ade439522d33d47df84401aa
https://pubmed.ncbi.nlm.nih.gov/34789487

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Differentiation of Cytochrome P450-Mediated from Non-CYP-Mediated Metabolism: Aldehyde Oxidase and Xanthine Oxidoreductase

Autor: Michael A. Zientek, Kirk D. Kozminski

Publikováno v: Methods in Pharmacology and Toxicology ISBN: 9781071615416

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::007bdc52382b32f50790c8f7446e0154
https://doi.org/10.1007/978-1-0716-1542-3_17

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Aldehyde oxidase activity in human vascular tissue and its potential contribution to extra-hepatic metabolism

Autor: Scott Heyward, Michael A. Zientek, Kirk D. Kozminski

Publikováno v: Drug Metabolism and Pharmacokinetics. 34:S62-S63

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24329b27110664c0911b08be3329fd80
https://doi.org/10.1016/j.dmpk.2018.09.217

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Voltammetric and pharmacological characterization of dopamine release from single exocytotic events at rat pheochromocytoma (PC12) cells

Autor: David A. Gutman, Andrew G. Ewing, Kirk D. Kozminski, David Sulzer, Viviana Davila

Publikováno v: Analytical chemistry. 70(15)

Although rat pheochromocytoma (PC12) neurotransmitter storage vesicles are known to contain a variety of neurotransmitters including catecholamines, there is little evidence that the molecular species detected during amperometric monitoring of exocyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a8e1cd4179db2daa744a1178f1c65b0
https://pubmed.ncbi.nlm.nih.gov/11013717

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