Výsledky vyhledávání - "Kirk D. Beebe"

Distinct Predictive Immunogenomic Profiles of Response to Immune Checkpoint Inhibitors and IL2: A Real-world Evidence Study of Patients with Advanced Renal Cancer

Autor: Joel R. Eisner, Kirk D. Beebe, Gregory M. Mayhew, Yoichiro Shibata, Yuelong Guo, Carol Farhangfar, Farhang Farhangfar, Joshua M. Uronis, Jill Mooney, Michael V. Milburn, David Foureau, Richard L. White, Asim Amin, Marcos E. Milla

Publikováno v: Cancer Research Communications. 2:894-903

Recombinant human high-dose IL2 (HD-IL2; aldesleukin) was one of the first approved immune-oncology agents based upon clinical activity in renal cell carcinoma (RCC) and metastatic melanoma but use was limited due to severe toxicity. Next-generation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3af86004040503294c91ba86fa069a5e
https://doi.org/10.1158/2767-9764.crc-21-0153

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Association of Antifolate Response Signature Status and Clinical Activity of Pemetrexed-Platinum Chemotherapy in Non-Small Cell Lung Cancer - The Piedmont Study

Autor: Joel R. Eisner, Gregory M. Mayhew, James M. Davison, Kirk D. Beebe, Yoichiro Shibata, Yuelong Guo, Carol Farhangfar, Farhang Farhangfar, Joshua M. Uronis, Jeffrey M. Conroy, Michael V. Milburn, David Neil. Hayes, Kathryn F. Mileham

Publikováno v: Clinical Cancer Research.

Purpose: The Piedmont study is a prospectively designed retrospective evaluation of a new 48-gene antifolate response signature (AF-PRS) in patients with locally advanced/metastatic NS-NSCLC treated with pemetrexed-containing platinum doublet chemoth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43c4953b0bb03f5b73d0ac32e56d115c
https://doi.org/10.1158/1078-0432.ccr-22-2558

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Real-world data validation of the PurIST pancreatic ductal adenocarcinoma gene expression classifier and its prognostic implications

Autor: Stephane Wenric, James M. Davison, John Guittar, Gregory M. Mayhew, Kirk D. Beebe, Yun E. Wang, Amrita A. Iyer, Hyunseok P. Kang, Michael V. Milburn, Vincent Chung, Tanios Bekaii-Saab, Charles M. Perou

BackgroundPancreatic ductal adenocarcinoma (PDAC) is amongst the deadliest cancers, with few modern tools to inform patient prognosis and help guide treatment options. Transcriptome-based molecular subtyping is one emerging technology that has been e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe5f2a6c4b61b76f6b921ebceead1bf2
https://doi.org/10.1101/2023.02.23.23286356

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Determination of the Binding Specificity of the SH2 Domains of Protein Tyrosine Phosphatase SHP-1 through the Screening of a Combinatorial Phosphotyrosyl Peptide Library

Autor: Gulnur Arabaci, Peng Wang, Kirk D. Beebe, Dehua Pei

Publikováno v: Biochemistry. 39:13251-13260

A method for the rapid identification of high-affinity ligands to Src homology-2 (SH2) domains is reported. A phosphotyrosyl (pY) peptide library containing completely randomized residues at positions -2 to +3 relative to the pY was synthesized on Te

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83e765d246aeccd545355ac9f11024ba
https://doi.org/10.1021/bi0014397

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Substrate Recognition through a PDZ Domain in Tail-Specific Protease

Autor: Jena Khera, Kirk D. Beebe, Dehua Pei, Chaity Chaudhury, Jing Peng, Jinu Shin

Publikováno v: Biochemistry. 39:3149-3155

Tail-specific protease (Tsp) is a periplasmic enzyme that selectively degrades proteins bearing a nonpolar C-terminus. Its substrate specificity suggests that Tsp may contain a substrate recognition domain, which selectively binds to the nonpolar C-t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbcd8eb9a0fa8883c3722c15f38a17c3
https://doi.org/10.1021/bi992709s

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alpha-Bromoacetophenone derivatives as neutral protein tyrosine phosphatase inhibitors: Structure-activity relationship

Autor: Kirk D. Beebe, Hua Fu, Tian Yi, Gulnur Arabaci, Dehua Pei, Mary E. Porter

A series of α-haloacetophenone derivatives was tested for inhibition of protein tyrosine phosphatases SHP-1 and PTP1B. The results show that the bromides are much more potent than the corresponding chlorides, whereas the phenyl ring is remarkably to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812416fddb88f5931623d9755b142f11
https://hdl.handle.net/20.500.12619/44905

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II. Structure and specificity of the interaction between the FHA2 domain of Rad53 and phosphotyrosyl peptides

Autor: Tsai, Kirk D. Beebe, I.J Byeon, P Wang, Hua Liao, Dehua Pei, Suganya Yongkiettrakul

Publikováno v: Journal of molecular biology. 302(4)

The forkhead-associated (FHA) domain is a protein module found in many proteins involved in cell signaling in response to DNA damage. It has been suggested to bind to pThr sites of its target protein. Recently we have determined the first structure o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3768004d1e1181a27cef915eb03f5c97
https://pubmed.ncbi.nlm.nih.gov/10993733

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