Zobrazeno 1 - 10
of 427
pro vyhledávání: '"Kirk C, Hansen"'
Autor:
Travis Nemkov, Francesca Cendali, Monika Dzieciatkowska, Daniel Stephenson, Kirk C. Hansen, Catherine M. Jankowski, Angelo D’Alessandro, Ryan J. Marker
Publikováno v:
Pathophysiology, Vol 31, Iss 1, Pp 166-182 (2024)
To molecularly characterize the impact of exercise on mitigating neoadjuvant treatment (NAT)-induced physical decline in pancreatic ductal adenocarcinoma (PDAC) patients, a multi-omics approach was employed for the analysis of plasma samples before a
Externí odkaz:
https://doaj.org/article/0b0186f221ec4f63b83ecbe9bbe07658
Autor:
Cara F. Smith, Zachary L. Nikolakis, Kathleen Ivey, Blair W. Perry, Drew R. Schield, Neil R. Balchan, Joshua Parker, Kirk C. Hansen, Anthony J. Saviola, Todd A. Castoe, Stephen P. Mackessy
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-19 (2023)
Abstract Background Snake venoms are trophic adaptations that represent an ideal model to examine the evolutionary factors that shape polymorphic traits under strong natural selection. Venom compositional variation is substantial within and among ven
Externí odkaz:
https://doaj.org/article/aa5c221351d6488a8948982a33432541
Autor:
Ming Pei, Yixuan Amy Pei, Sheng Zhou, Elmira Mikaeiliagah, Christopher Erickson, Benjamin Giertych, Halima Akhter, Lei Wang, Amanda Stewart, Joshua Parenti, Bin Wang, Sijin Wen, Sotcheadt Sim, Eric Quenneville, Kirk C. Hansen, Steven Frisch, Gangqing Hu
Publikováno v:
Bioactive Materials, Vol 23, Iss , Pp 353-367 (2023)
Articular cartilage has a limited capacity to self-heal once damaged. Tissue-specific stem cells are a solution for cartilage regeneration; however, ex vivo expansion resulting in cell senescence remains a challenge as a large quantity of high-qualit
Externí odkaz:
https://doaj.org/article/749909a10c854770aaeba20cc38892e0
Autor:
Kristen M. Stearns-Reider, Michael R. Hicks, Katherine G. Hammond, Joseph C. Reynolds, Alok Maity, Yerbol Z. Kurmangaliyev, Jesse Chin, Adam Z. Stieg, Nicholas A. Geisse, Sophia Hohlbauch, Stefan Kaemmer, Lauren R. Schmitt, Thanh T. Pham, Ken Yamauchi, Bennett G. Novitch, Roy Wollman, Kirk C. Hansen, April D. Pyle, Rachelle H. Crosbie
Publikováno v:
npj Regenerative Medicine, Vol 8, Iss 1, Pp 1-22 (2023)
Abstract We developed an on-slide decellularization approach to generate acellular extracellular matrix (ECM) myoscaffolds that can be repopulated with various cell types to interrogate cell-ECM interactions. Using this platform, we investigated whet
Externí odkaz:
https://doaj.org/article/c2a5068dfc864da18363d4d91d1aaa4b
Autor:
Jackie L. McCourt, Kristen M. Stearns-Reider, Hafsa Mamsa, Pranav Kannan, Mohammad Hossein Afsharinia, Cynthia Shu, Elizabeth M. Gibbs, Kara M. Shin, Yerbol Z. Kurmangaliyev, Lauren R. Schmitt, Kirk C. Hansen, Rachelle H. Crosbie
Publikováno v:
Skeletal Muscle, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract Background The dystrophin-glycoprotein complex (DGC) is a critical adhesion complex of the muscle cell membrane, providing a mechanical link between the extracellular matrix (ECM) and the cortical cytoskeleton that stabilizes the sarcolemma
Externí odkaz:
https://doaj.org/article/b2cf4b0572df49f7aea7868e8825730a
Autor:
Wilbert L. Jones, Christopher R. Ramos, Anirban Banerjee, Ernest E. Moore, Kirk C. Hansen, Julia R. Coleman, Marguerite Kelher, Keith B. Neeves, Christopher C. Silliman, Jorge Di Paola, Brian Branchford
Publikováno v:
Platelets, Vol 33, Iss 8, Pp 1119-1131 (2022)
Apolipoprotein A-I (ApoA-I) is elevated in the plasma of a subgroup of trauma patients with systemic hyperfibrinolysis. We hypothesize that apoA-I inhibits platelet activation and clot formation. The effects of apoA-I on human platelet activation and
Externí odkaz:
https://doaj.org/article/431566e32a634e068a99c0c4b4495a3e
Autor:
Brianna J. Klein, Jordan T. Feigerle, Jibo Zhang, Christopher C. Ebmeier, Lixin Fan, Rohit K. Singh, Wesley W. Wang, Lauren R. Schmitt, Thomas Lee, Kirk C. Hansen, Wenshe R. Liu, Yun-Xing Wang, Brian D. Strahl, P. Anthony Weil, Tatiana G. Kutateladze
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Here the authors report that the Taf2 and Taf14 subunits of the yeast TFIID complex interact and mediate binding to chromatin. Binding of Taf2 to Taf14 promotes a conformational rearrangement in Taf14, resulting in a release of the linker region for
Externí odkaz:
https://doaj.org/article/effb294868064bf0976b394ca5ad6eec
Autor:
Stephanie L. K. Bowers, Qinghang Meng, Yasuhide Kuwabara, Jiuzhou Huo, Rachel Minerath, Allen J. York, Michelle A. Sargent, Vikram Prasad, Anthony J. Saviola, David Ceja Galindo, Kirk C. Hansen, Ronald J. Vagnozzi, Katherine E. Yutzey, Jeffery D. Molkentin
Publikováno v:
Cells, Vol 12, Iss 17, p 2174 (2023)
Rationale: The adult cardiac extracellular matrix (ECM) is largely comprised of type I collagen. In addition to serving as the primary structural support component of the cardiac ECM, type I collagen also provides an organizational platform for other
Externí odkaz:
https://doaj.org/article/bc1cebba95e0499bb087b9d6cd86552f
Autor:
Daniel S. Han, Christopher Erickson, Kirk C. Hansen, Lara Kirkbride-Romeo, Zhibin He, Christopher B. Rodell, Danielle E. Soranno
Publikováno v:
Cells, Vol 12, Iss 13, p 1771 (2023)
The translation of stem cell therapies has been hindered by low cell survival and retention rates. Injectable hydrogels enable the site-specific delivery of therapeutic cargo, including cells, to overcome these challenges. We hypothesized that delive
Externí odkaz:
https://doaj.org/article/21f10066b3644820a04ca0fb0c8b54e4
Autor:
Sue Gu, Claudia Mickael, Rahul Kumar, Michael H. Lee, Linda Sanders, Biruk Kassa, Julie Harral, Jason Williams, Kirk C. Hansen, Kurt R. Stenmark, Rubin M. Tuder, Brian B. Graham
Publikováno v:
Pulmonary Circulation, Vol 12, Iss 3, Pp n/a-n/a (2022)
Abstract Right ventricular (RV) failure is the primary cause of death in pulmonary hypertension (PH), but the mechanisms of RV failure are not well understood. We hypothesized macrophages in the RV contribute to the RV response in PH. We induced PH i
Externí odkaz:
https://doaj.org/article/783929df348a4cba9dd4c63c25ba23b0