Role of mucin glycosylation in the gut microbiota-brain axis of core 3 O-glycan deficient mice

Autor: Erika Coletto, George M. Savva, Dimitrios Latousakis, Matthew Pontifex, Emmanuelle H. Crost, Laura Vaux, Andrea Telatin, Kirk Bergstrom, David Vauzour, Nathalie Juge

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)

Abstract Alterations in intestinal mucin glycosylation have been associated with increased intestinal permeability and sensitivity to inflammation and infection. Here, we used mice lacking core 3-derived O-glycans (C3GnT−/−) to investigate the ef

Externí odkaz: https://doaj.org/article/5015c207057d485aa595396c2bc0750d

Sweet-talk in the time of cholera: host mucin negotiates peace with Vibrio cholerae

Autor: Kirk Bergstrom

Publikováno v: The EMBO journalReferences.

Vibrio cholerae, the causative agent of cholera, must first be converted to its toxigenic form and cross the sugar-rich mucus barrier before it can cause disease, but whether these hurdles are linked is unclear. In this issue, Wang et al (2022) provi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e8f26e466af120328a7e49fd60cb79
https://pubmed.ncbi.nlm.nih.gov/36573348

Reporting guidelines for human microbiome research: the STORMS checklist

Autor: Dermot P.B. McGovern, Suzanne Devkota, Eran Segal, Rimsha Azhar, Thomas Sharpton, Douglas S Kwon, Massive Analysis, Elizabeth Grice, Eran Elinav, Jonathan Braun, Louise B. Thingholm, Paul Wilmes, Benjamin Haibe-Kains, Wendell D. Jones, Sofia Forslund, David Casero, Russell D. Wolfinger, Kirk Bergstrom, Ramona L Walls, Rebecca Kusko, Pamela Herd, Viswanath Devanarayan, Fatima Zohra, Brianna Lindsay, Aedin Culhane, Francesco Beghini, Heidi E. Jones, Maria Carmen Collado, Mingyu Zhang, Wenjun Bao, Robert D. Finn, Liping Zhao, Jonathan P Jacobs, Andreas Scherer, Xiaohui Fan, Omry Koren, Jennifer Fettweis, Morgan G. I. Langille, Weida Tong, Jordan E Bisanz, Malte Rühlemann, Curtis Huttenhower, Scott Handley, Rob Knight, Susanna-Assunta Sansone, Shannon McWeeney, Gregory A Buck, Sujatha Srinivasan, Jennifer B Dowd, Ekaterina Smirnova, Amy Loughman, Janneke van de Wijgert, Audrey Renson, Frederic D. Bushman, John F. Cryan, Christopher E. Mason, Levi Waldron, Harry Sokol, Susan Holmes, Andre Franke, Leming Shi, Anthony A. Fodor, Nicola Segata, Matthew R. Redinbo, Matthew Olm, Jeroen Raes, David A MacIntyre, Luigi Nezi, Joaquin Dopazo, Shaimaa Elsafoury, Kelly Eckenrode, Francine Z Marques, Peter J. Turnbaugh, Ni Zhao, Christopher Hunter, Lynn Schriml, Georg Zeller, Jack Gilbert, Ami Bhatt, Noah Palm, Ludwig Geistlinger, Juan S Escobar, Michelle Shardell, Dan Knights, Tim R Mercer, Vaibhav Upadhyay, Shraddha Thakkar, Noel T. Mueller, Manimozhiyan Arumugam, Paul D. Cotter, Gerard Clarke, Alice C. McHardy, Lisa Karstens, Cesare Furlanello, Edoardo Pasolli, Chloe Mirzayi, Justin L Sonnenburg, Ryan T Demmer, Patrick D. Schloss, Lora J. Kasselman, Takuji Yamada, Matthias Fischer, Hector Corrada Bravo, R Balfour Sartor

Publikováno v: Nature Medicine
Mirzayi, C, Renson, A, Furlanello, C, Sansone, S A, Zohra, F, Elsafoury, S, Geistlinger, L, Kasselman, L J, Eckenrode, K, van de Wijgert, J, Loughman, A, Marques, F Z, MacIntyre, D A, Arumugam, M, Azhar, R, Beghini, F, Bergstrom, K, Bhatt, A, Bisanz, J E, Braun, J, Bravo, H C, Buck, G A, Bushman, F, Casero, D, Clarke, G, Collado, M C, Cotter, P D, Cryan, J F, Demmer, R T, Devkota, S, Elinav, E, Escobar, J S, Fettweis, J, Finn, R D, Fodor, A A, Forslund, S, Franke, A, Furlanello, C, Gilbert, J, Grice, E, Haibe-Kains, B, Handley, S, Herd, P, Holmes, S, Jacobs, J P, Karstens, L, Knight, R, Knights, D, Koren, O, Kwon, D S, Genomic Standards Consortium & Massive Analysis and Quality Control Society 2021, ' Reporting guidelines for human microbiome research : the STORMS checklist ', Nature Medicine, vol. 27, no. 11, pp. 1885-1892 . https://doi.org/10.1038/s41591-021-01552-x

The particularly interdisciplinary nature of human microbiome research makes the organization and reporting of results spanning epidemiology, biology, bioinformatics, translational medicine and statistics a challenge. Commonly used reporting guidelin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05fb1419335ae65792add0c13bb9500c
http://hdl.handle.net/11572/355066

Core 1–derived mucin-type O-glycosylation protects against spontaneous gastritis and gastric cancer

Autor: Fei Liu, Xindi Shan, Kirk Bergstrom, Jianxin Fu, Weichang Chen, Xia Bai, Lijun Xia, J. Michael McDaniel, Samuel McGee

Publikováno v: The Journal of Experimental Medicine

Mucin-type O-glycans (O-glycans) are a major component of gastric mucus with an unclear function. Liu et al. reports that O-glycans protect gastric mucosa from inflammation and cancer mediated by activation of caspases 1 and 11–dependent inflammaso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29b4eed54b384326a3ce73e5fc4add07
https://doi.org/10.1084/jem.20182325

Loss of mucin-type

Autor: Kai, Song, Jianxin, Fu, Jianhua, Song, Brett H, Herzog, Kirk, Bergstrom, Yuji, Kondo, J Michael, McDaniel, Samuel, McGee, Robert, Silasi-Mansat, Florea, Lupu, Hong, Chen, Harini, Bagavant, Lijun, Xia

Publikováno v: The Journal of biological chemistry. 292(40)

The kidney's filtration activity is essential for removing toxins and waste products from the body. The vascular endothelial cells of the glomerulus are fenestrated, flattened, and surrounded by podocytes, specialized cells that support glomerular en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::723d9a8bd28ffc1c2f06adbf701ecbd6
https://pubmed.ncbi.nlm.nih.gov/28842487