Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Kirk B, Lane"'
Autor:
Megha Talati, Haitham Mutlak, Kirk B. Lane, Wei Han, Anna Hemnes, Outi Mutlak, Tom Blackwell, Rinat Zaynagetdinov, Timothy S. Blackwell, James West
Publikováno v:
Diseases, Vol 2, Iss 2, Pp 148-167 (2014)
Aim: The present study investigates the role of NF-κB in Bmpr2-related pulmonary hypertension (PH) using a murine model of PH with inducible overexpression of a cytoplasmic tail Bmpr2 mutation. Methods and Results: Electrophoretic mobility shift ass
Externí odkaz:
https://doaj.org/article/df81727870de4bbc8cebe6c5402aeeca
Autor:
Kirk B. Lane, Outi Mutlak, James West, Anna R. Hemnes, Timothy S. Blackwell, Haitham Mutlak, Megha Talati, Thomas R. Blackwell, Wei Han, Rinat Zaynagetdinov
Publikováno v:
Diseases, Vol 2, Iss 2, Pp 148-167 (2014)
Diseases
Volume 2
Issue 2
Pages 148-167
Diseases
Volume 2
Issue 2
Pages 148-167
Aim: The present study investigates the role of NF-κB in Bmpr2-related pulmonary hypertension (PH) using a murine model of PH with inducible overexpression of a cytoplasmic tail Bmpr2 mutation. Methods and Results: Electrophoretic mobility shift ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb829a713c9cbcbb8a184c226d2b8776
https://doi.org/10.3390/diseases2020148
https://doi.org/10.3390/diseases2020148
Publikováno v:
Pulmonary Circulation. 3:533-550
The natural history of familial pulmonary arterial hypertension (PAH) typically involves mutations in and/or haploinsuffciency of BMPR2 (gene for bone morphogenetic protein receptor type 2) but with low penetrance (10%-15%), delayed onset (in the thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bceaa6981c52beef4d8c0facdcd0d0e
https://doi.org/10.1086/674336
https://doi.org/10.1086/674336
Autor:
Joy D. Cogan, Linda Robinson, Eric D. Austin, Lora K. Hedges, Kelly Fox, James West, John H. Newman, Swapna Menon, Anna R. Hemnes, Megha Talati, James E. Loyd, Rizwan Hamid, Kirk B. Lane, Ivan M. Robbins
Publikováno v:
Pulmonary Circulation
The majority of pulmonary arterial hypertension (PAH) is not associated with BMPR2 mutation, and major risk factors for idiopathic PAH are not known. The objective of this study was to identify a gene expression signature for IPAH. To accomplish this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6786e848389f9a2fb4d51aa84ba30d45
http://europepmc.org/articles/PMC3224431
http://europepmc.org/articles/PMC3224431
Autor:
Thomas R. Blackwell, Kirk B. Lane, Radhika Gaddipati, Kirsten A. Lane, Nicole M. Lane, James West, James E. Loyd
Publikováno v:
American Journal of Molecular Biology. :131-139
In this study, RLM-RACE was used to identify the transcriptional start site 387 bp upstream of the translational start. Evolutionarily conserved transcription factor binding sites were identified, and a series of luciferase reporter constructs driven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e311d9d909ab0dfd28a4269e63499122
https://doi.org/10.4236/ajmb.2011.13014
https://doi.org/10.4236/ajmb.2011.13014
Autor:
Kirk B. Lane, Semra Bilaceroglu, Kejing Tang, Kenneth J. Salleng, Ioannis Kalomenidis, Richard W. Light, Yubiao Guo
Publikováno v:
Respirology. 15:119-125
Background and objective: The mechanism by which iodopovidone achieves pleurodesis is unknown. This study investigated whether iodopovidone is as effective as doxycycline in producing pleurodesis and whether systemic corticosteroids diminish its effi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85448d257b0334fccce498b53ea7c7bf
https://doi.org/10.1111/j.1440-1843.2009.01671.x
https://doi.org/10.1111/j.1440-1843.2009.01671.x
Autor:
Kirk B. Lane, Wonder P. Drake, Moon Jun Na, Huai Liao, Steven Idell, Andrey A. Komissarov, Torry A. Tucker, A. E. Gazar, Richard W. Light, Kathy Koenig
Publikováno v:
Experimental Lung Research. 35:665-681
Intrapleural fibrin deposition and subsequent fibrosis characterize evolving empyema and contribute to the morbidity associated with this condition. Single-chain urokinase (scuPA) is proenzyme form of the urokinase plasminogen activator, which has re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::accc35727467fca717bddb254070a933
https://doi.org/10.3109/01902140902833277
https://doi.org/10.3109/01902140902833277
Autor:
Daniel J. Crona, Brian Ickes, Kirk B. Lane, Karen A. Fagan, Sebastian Albu, Duncan J. Stewart, Yupu Deng, Julie W. Harral, James West
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 295:L744-L755
Familial pulmonary arterial hypertension (PAH) is associated with mutations in bone morphogenetic protein type II receptor (BMPR2). Many of these mutations occur in the BMPR2 tail domain, leaving the SMAD functions intact. To determine the in vivo co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02d2a01ebbcc47ad01003a1d656b31d2
https://doi.org/10.1152/ajplung.90255.2008
https://doi.org/10.1152/ajplung.90255.2008
Autor:
James A. Mobley, Kirk B. Lane, Lillian B. Nanney, Joey C. Latham, Vasiliy V. Polosukhin, Pierre Chaurand, Pamela S. Wirth, Richard M. Caprioli
Publikováno v:
Journal of Proteome Research. 7:3543-3555
Imaging mass spectrometry is becoming a key technology for the investigation of the molecular content of biological tissue sections in direct correlation with the underlying histology. Much of our work has been done with fresh-frozen tissue sections
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ee6e3df9ca2b4f781c99416e4ad669f
https://doi.org/10.1021/pr800286z
https://doi.org/10.1021/pr800286z
Autor:
Kirk B. Lane, Peter F. Crossno, Timothy S. Blackwell, William Lawson, Juan Roldan, Carol Xu, Thomas R. Blackwell, Geraldine G. Miller, James E. Loyd, Cheryl Markin, Dong-Sheng Cheng, Lorraine B. Ware, Vasiliy V. Polosukhin
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 294:L1119-L1126
Recent evidence suggests that dysfunctional type II alveolar epithelial cells (AECs) contribute to the pathogenesis of idiopathic pulmonary fibrosis (IPF). Based on the hypothesis that disease-causing mutations in surfactant protein C ( SFTPC) provid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8376a75ddb66f9f1ba7d8a5003feb3c1
https://doi.org/10.1152/ajplung.00382.2007
https://doi.org/10.1152/ajplung.00382.2007