Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Kirk A Rockett"'
Autor:
D Herbert Opi, Carolyne M Ndila, Sophie Uyoga, Alex W Macharia, Clare Fennell, Lucy B Ochola, Gideon Nyutu, Bethseba R Siddondo, John Ojal, Mohammed Shebe, Kennedy O Awuondo, Neema Mturi, Norbert Peshu, Benjamin Tsofa, Gavin Band, Kathryn Maitland, Dominic P Kwiatkowski, Kirk A Rockett, Thomas N Williams, J Alexandra Rowe
Publikováno v:
PLoS Genetics, Vol 19, Iss 9, p e1010910 (2023)
Blood group O is associated with protection against severe malaria and reduced size and stability of P. falciparum-host red blood cell (RBC) rosettes compared to non-O blood groups. Whether the non-O blood groups encoded by the specific ABO genotypes
Externí odkaz:
https://doaj.org/article/07fa8bb0e3a9466b93188d388f8991ef
Autor:
James J Gilchrist, Kathryn Auckland, Tom Parks, Alexander J Mentzer, Lily Goldblatt, Vivek Naranbhai, Gavin Band, Kirk A Rockett, Ousmane B Toure, Salimata Konate, Sibiri Sissoko, Abdoulaye A Djimdé, Mahamadou A Thera, Ogobara K Doumbo, Samba Sow, Sian Floyd, Jörg M Pönnighaus, David K Warndorff, Amelia C Crampin, Paul E M Fine, Benjamin P Fairfax, Adrian V S Hill
Publikováno v:
PLoS Pathogens, Vol 18, Iss 9, p e1010312 (2022)
Leprosy is a chronic infection of the skin and peripheral nerves caused by Mycobacterium leprae. Despite recent improvements in disease control, leprosy remains an important cause of infectious disability globally. Large-scale genetic association stu
Externí odkaz:
https://doaj.org/article/1b686b47b5c44125a70cea80ed468575
Autor:
James J Gilchrist, Silvia N Kariuki, James A Watson, Gavin Band, Sophie Uyoga, Carolyne M Ndila, Neema Mturi, Salim Mwarumba, Shebe Mohammed, Moses Mosobo, Kaur Alasoo, Kirk A Rockett, Alexander J Mentzer, Dominic P Kwiatkowski, Adrian VS Hill, Kathryn Maitland, J Anthony G Scott, Thomas N Williams
Publikováno v:
eLife, Vol 11 (2022)
Invasive bacterial disease is a major cause of morbidity and mortality in African children. Despite being caused by diverse pathogens, children with sepsis are clinically indistinguishable from one another. In spite of this, most genetic susceptibili
Externí odkaz:
https://doaj.org/article/5b632ded377f43c8bc16485a42752ec1
Autor:
D Herbert Opi, Olivia Swann, Alexander Macharia, Sophie Uyoga, Gavin Band, Carolyne M Ndila, Ewen M Harrison, Mahamadou A Thera, Abdoulaye K Kone, Dapa A Diallo, Ogobara K Doumbo, Kirsten E Lyke, Christopher V Plowe, Joann M Moulds, Mohammed Shebbe, Neema Mturi, Norbert Peshu, Kathryn Maitland, Ahmed Raza, Dominic P Kwiatkowski, Kirk A Rockett, Thomas N Williams, J Alexandra Rowe
Publikováno v:
eLife, Vol 7 (2018)
Malaria has been a major driving force in the evolution of the human genome. In sub-Saharan African populations, two neighbouring polymorphisms in the Complement Receptor One (CR1) gene, named Sl2 and McCb, occur at high frequencies, consistent with
Externí odkaz:
https://doaj.org/article/edf04747e72c4233ba6dfb7dbeacb907
Autor:
Hsiao-Han Chang, Colin J Worby, Adoke Yeka, Joaniter Nankabirwa, Moses R Kamya, Sarah G Staedke, Grant Dorsey, Maxwell Murphy, Daniel E Neafsey, Anna E Jeffreys, Christina Hubbart, Kirk A Rockett, Roberto Amato, Dominic P Kwiatkowski, Caroline O Buckee, Bryan Greenhouse
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 1, p e1005348 (2017)
As many malaria-endemic countries move towards elimination of Plasmodium falciparum, the most virulent human malaria parasite, effective tools for monitoring malaria epidemiology are urgent priorities. P. falciparum population genetic approaches offe
Externí odkaz:
https://doaj.org/article/92280b39ac4b463db1b1b7f43b49dd31
Autor:
George BJ Busby, Gavin Band, Quang Si Le, Muminatou Jallow, Edith Bougama, Valentina D Mangano, Lucas N Amenga-Etego, Anthony Enimil, Tobias Apinjoh, Carolyne M Ndila, Alphaxard Manjurano, Vysaul Nyirongo, Ogobara Doumba, Kirk A Rockett, Dominic P Kwiatkowski, Chris CA Spencer, Malaria Genomic Epidemiology Network
Publikováno v:
eLife, Vol 5 (2016)
Similarity between two individuals in the combination of genetic markers along their chromosomes indicates shared ancestry and can be used to identify historical connections between different population groups due to admixture. We use a genome-wide,
Externí odkaz:
https://doaj.org/article/5b2b03f776f549b38b5bd23d0f4ee61e
Autor:
Jason P Wendler, John Okombo, Roberto Amato, Olivo Miotto, Steven M Kiara, Leah Mwai, Lewa Pole, John O'Brien, Magnus Manske, Dan Alcock, Eleanor Drury, Mandy Sanders, Samuel O Oyola, Cinzia Malangone, Dushyanth Jyothi, Alistair Miles, Kirk A Rockett, Bronwyn L MacInnis, Kevin Marsh, Philip Bejon, Alexis Nzila, Dominic P Kwiatkowski
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96486 (2014)
Drug resistance remains a chief concern for malaria control. In order to determine the genetic markers of drug resistant parasites, we tested the genome-wide associations (GWA) of sequence-based genotypes from 35 Kenyan P. falciparum parasites with t
Externí odkaz:
https://doaj.org/article/d32bcf6025e640c29e09d66f4d6a85d5
Autor:
Gavin Band, Quang Si Le, Luke Jostins, Matti Pirinen, Katja Kivinen, Muminatou Jallow, Fatoumatta Sisay-Joof, Kalifa Bojang, Margaret Pinder, Giorgio Sirugo, David J Conway, Vysaul Nyirongo, David Kachala, Malcolm Molyneux, Terrie Taylor, Carolyne Ndila, Norbert Peshu, Kevin Marsh, Thomas N Williams, Daniel Alcock, Robert Andrews, Sarah Edkins, Emma Gray, Christina Hubbart, Anna Jeffreys, Kate Rowlands, Kathrin Schuldt, Taane G Clark, Kerrin S Small, Yik Ying Teo, Dominic P Kwiatkowski, Kirk A Rockett, Jeffrey C Barrett, Chris C A Spencer, Malaria Genomic Epidemiology Network, Malaria Genomic Epidemiological Network
Publikováno v:
PLoS Genetics, Vol 9, Iss 5, p e1003509 (2013)
Combining data from genome-wide association studies (GWAS) conducted at different locations, using genotype imputation and fixed-effects meta-analysis, has been a powerful approach for dissecting complex disease genetics in populations of European an
Externí odkaz:
https://doaj.org/article/dd877dc78f1d428cbcceaa37cc85a325
Autor:
Tobias O Apinjoh, Judith K Anchang-Kimbi, Clarisse Njua-Yafi, Regina N Mugri, Andre N Ngwai, Kirk A Rockett, Eric Mbunwe, Richard N Besingi, Taane G Clark, Dominic P Kwiatkowski, Eric A Achidi, MalariaGEN Consortium
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e81071 (2013)
P. falciparum malaria is one of the most widespread and deadliest infectious diseases in children under five years in endemic areas. The disease has been a strong force for evolutionary selection in the human genome, and uncovering the critical human
Externí odkaz:
https://doaj.org/article/a70f392a95b543d7a1952f207ecf1e63
Autor:
Bakary Maiga, Amagana Dolo, Ousmane Touré, Victor Dara, Amadou Tapily, Susana Campino, Nuno Sepulveda, Paul Risley, Nilupa Silva, Patrick Corran, Kirk A Rockett, Dominic Kwiatkowski, MalariaGEN Consortium, Taane G Clark, Marita Troye-Blomberg, Ogobara K Doumbo
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e75675 (2013)
Malaria still remains a major public health problem in Mali, although disease susceptibility varies between ethnic groups, particularly between the Fulani and Dogon. These two sympatric groups share similar socio-cultural factors and malaria transmis
Externí odkaz:
https://doaj.org/article/c3d0869815004e269ae2b5d180bbd1a9