Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Kirk, Nelson"'
Autor:
Dongxu, Sun, Ruslan, Tsivkovski, Joe, Pogliano, Hannah, Tsunemoto, Kirk, Nelson, Debora, Rubio-Aparicio, Olga, Lomovskaya
Publikováno v:
Antimicrobial agents and chemotherapy. 66(10)
Xeruborbactam (formerly QPX7728) is a cyclic boronate inhibitor of numerous serine and metallo-beta-lactamases. At concentrations generally higher than those required for beta-lactamase inhibition, xeruborbactam has direct antibacterial activity agai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9752c54a8080f4ae679e65bb7031fccf
https://pubmed.ncbi.nlm.nih.gov/36102663
https://pubmed.ncbi.nlm.nih.gov/36102663
Autor:
Olga Lomovskaya, Maxim Totrov, Dongxu Sun, K. Raja Reddy, Tomasz W. Glinka, Mojgan Sabet, Debora Rubio-Aparicio, Serge H. Boyer, Orville A. Pemberton, Ruslan Tsivkovski, Scott J. Hecker, Michael N. Dudley, David C. Griffith, Jonathan Parkinson, Kirk Nelson, Yu Chen, Ziad Tarazi
Publikováno v:
Journal of Medicinal Chemistry. 63:7491-7507
Despite major advances in the β-lactamase inhibitor field, certain enzymes remain refractory to inhibition by agents recently introduced. Most important among these are the class B (metallo) enzyme NDM-1 of Enterobacteriaceae and the class D (OXA) e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0120b5dd24d3ace9b34c3d9db7858b70
https://doi.org/10.1021/acs.jmedchem.9b01976
https://doi.org/10.1021/acs.jmedchem.9b01976
Autor:
Debora Rubio-Aparicio, Olga Lomovskaya, Mariana Castanheira, Jeffery S. Loutit, Dongxu Sun, Kirk Nelson, Jill M. Lindley, Ruslan Tsivkovski, Michael N. Dudley
Publikováno v:
Antimicrobial Agents and Chemotherapy
QPX7728 is an ultrabroad-spectrum beta-lactamase inhibitor with potent inhibition of key serine and metallo beta-lactamases. QPX7728 enhances the potency of multiple beta-lactams in beta-lactamase-producing Enterobacterales and Acinetobacter spp. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0290222a344dd1c50ba5b6008fc88bb9
http://europepmc.org/articles/PMC8315991
http://europepmc.org/articles/PMC8315991
Autor:
Olga Lomovskaya, Maxim Totrov, Dongxu Sun, Kirk Nelson, Michael N. Dudley, Debora Rubio-Aparicio, Ruslan Tsivkovski
Publikováno v:
Antimicrob Agents Chemother
QPX7728 is a recently discovered ultra-broad-spectrum beta-lactamase inhibitor (BLI) with potent inhibition of key serine and metallo-beta-lactamases. QPX7728 enhances the potency of many beta-lactams, including carbapenems, in beta-lactamase-produci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44e128d6e5b6e17cfebf96e152dbf117
https://doi.org/10.1128/aac.01406-20
https://doi.org/10.1128/aac.01406-20
Publikováno v:
Antimicrob Agents Chemother
QPX7728 is an investigational ultrabroad-spectrum-beta-lactamase inhibitor (BLI) with potent inhibition of key serine and metallo-beta-lactamases. QPX7728 enhances the potency of many beta-lactams, including carbapenems, in isogenic strains of Gram-n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbdd6840e0bc95da7f0890f46e1e7580
https://doi.org/10.1128/aac.00757-20
https://doi.org/10.1128/aac.00757-20
Autor:
Dongxu Sun, Olga Lomovskaya, Michael N. Dudley, Kirk Nelson, Ruslan Tsivkovski, Debora Rubio-Aparicio
Publikováno v:
Antimicrobial Agents and Chemotherapy
QPX7728 is an ultrabroad-spectrum boronic acid beta-lactamase inhibitor that demonstrates inhibition of key serine and metallo-beta-lactamases at a nanomolar concentration range in biochemical assays with purified enzymes. The broad-spectrum inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::513cea585ddb065c16f09d1c996aa931
http://europepmc.org/articles/PMC7269478
http://europepmc.org/articles/PMC7269478
Autor:
Debora Rubio-Aparicio, Dongxu Sun, Maxim Totrov, Olga Lomovskaya, Kirk Nelson, Michael N. Dudley, Ruslan Tsivkovski
Publikováno v:
Antimicrobial Agents and Chemotherapy
QPX7728 is an ultrabroad-spectrum boronic acid beta-lactamase inhibitor, with potent inhibition of key serine and metallo-beta-lactamases being observed in biochemical assays. Microbiological studies using characterized strains were used to provide a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ecaee1216998118a930341e909e56ce
http://europepmc.org/articles/PMC7269471
http://europepmc.org/articles/PMC7269471
Publikováno v:
Open Forum Infectious Diseases
Background QPX7728 (QPX) is a novel broad-spectrum boron-containing inhibitor of serine- and metallo-β-lactamases (MBLs). We evaluated the in vitro activity of QPX combined with several β-lactams against carbapenem-resistant AB (CRAB) and PSA clini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25fb651d98582628b641ee8177dfe7d3
https://doi.org/10.1093/ofid/ofz360.749
https://doi.org/10.1093/ofid/ofz360.749
Publikováno v:
Antimicrobial Agents and Chemotherapy
Vaborbactam (formerly RPX7009) is a new β-lactamase inhibitor based on a cyclic boronic acid pharmacophore with potent inhibitory activity against K lebsiella p neumoniae c arbapenemases (KPC). It has been developed in combination with meropenem. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6fd7ad28407d806586f7e39d0d24c46
https://doi.org/10.1128/aac.01694-17
https://doi.org/10.1128/aac.01694-17
Autor:
Dongxu Sun, Michael N. Dudley, Mark A. Redell, Visanu Thamlikitkul, Olga Lomovskaya, Debora Rubio-Aparicio, Kirk Nelson
Publikováno v:
International journal of antimicrobial agents. 52(3)
Minocycline is one of the few options available to treat infections caused by Acinetobacter baumannii. Acquired resistance to minocycline in A. baumannii is associated with presence of the TetB efflux pump. Previous studies suggested that the absence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13807385a5c80708be5cebf82b16ed4f
https://pubmed.ncbi.nlm.nih.gov/29665446
https://pubmed.ncbi.nlm.nih.gov/29665446