Zobrazeno 1 - 6 of 6 pro vyhledávání: '"Kirill P. Cheremnykh"'
1
Akademický článek
Synthesis, Pharmacological Evaluation, and Molecular Modeling of Lappaconitine–1,5-Benzodiazepine Hybrids
Autor: Kirill P. Cheremnykh, Arkadiy O. Bryzgalov, Dmitry S. Baev, Sergey A. Borisov, Yulia S. Sotnikova, Victor A. Savelyev, Tatyana G. Tolstikova, Shamansur S. Sagdullaev, Elvira E. Shults
Publikováno v: Molecules, Vol 28, Iss 10, p 4234 (2023)
Diterpenoid alkaloids, originating from the amination of natural tetracyclic diterpenes, have long interested scientists due to their medicinal uses and infamous toxicity which has limited the clinical application of the native compound. Alkaloid lap
Externí odkaz: https://doaj.org/article/3287ddae6ee24a06a3d5bae10f9f428c
Zobrazit plný text záznamu
2
Akademický článek
Hybrides of Alkaloid Lappaconitine with Pyrimidine Motif on the Anthranilic Acid Moiety: Design, Synthesis, and Investigation of Antinociceptive Potency
Autor: Kirill P. Cheremnykh, Victor A. Savelyev, Sergey A. Borisov, Igor D. Ivanov, Dmitry S. Baev, Tatyana G. Tolstikova, Valentin A. Vavilin, Elvira E. Shults
Publikováno v: Molecules, Vol 25, Iss 23, p 5578 (2020)
Convenient and efficient routes to construct hybrid molecules containing diterpene alkaloid lappaconitine and pyrimidine fragments are reported. One route takes place via first converting of lappaconitine to 1-ethynyl-lappaconitine, followed by the S
Externí odkaz: https://doaj.org/article/370d12c351794842b5b1a369f3139859
Zobrazit plný text záznamu
4
Design, synthesis, cytotoxicity, and molecular modeling study of 2,4,6-trisubstituted pyrimidines with anthranilate ester moiety
Autor: Elvira E. Shults, M. A. Pokrovskii, Kirill P. Cheremnykh, Victor A. Savelyev, Tatyana G. Tolstikova, Dmitry S. Baev, A. G. Pokrovskii
Publikováno v: Medicinal Chemistry Research. 28:545-558
A series of 2,4,6-trisubstituted pyrimidines with antharanilic acid ester moiety have been designed and synthesized by employing a one-pot multicomponent approach from methyl 5-(ethynyl)anthranilate, aroyl or cinnamoyl chlorides and various amidines.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b71c8c83c401cab4245455c359f7009c
https://doi.org/10.1007/s00044-019-02314-8
Zobrazit plný text záznamu
5
Synthesis of hybrid molecules containing pyrimidine and diterpene alkaloid lappaconitine fragments
Autor: Elvira E. Shults, Viktor А. Savel’ev, Kirill P. Cheremnykh, Oleg P. Shkurko
Publikováno v: Chemistry of Heterocyclic Compounds. 54:1131-1138
The cross coupling of 5'-ethynyllappaconitine with benzoic acid chlorides under the conditions of the Sonogashira reaction in benzene leads to the corresponding 5-alkynones. By condensation of the obtained 5'-alkynones with amidines, compounds with h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::352f4e1541635b02c483c2bff89b5699
https://doi.org/10.1007/s10593-019-02404-w
Zobrazit plný text záznamu
6
Hybrides of Alkaloid Lappaconitine with Pyrimidine Motif on the Anthranilic Acid Moiety: Design, Synthesis, and Investigation of Antinociceptive Potency
Autor: Valentin A. Vavilin, Dmitry S. Baev, Tatyana G. Tolstikova, Elvira E. Shults, Victor A. Savelyev, Sergey A. Borisov, Kirill P. Cheremnykh, Igor D. Ivanov
Publikováno v: Molecules
Volume 25
Issue 23
Molecules, Vol 25, Iss 5578, p 5578 (2020)
Convenient and efficient routes to construct hybrid molecules containing diterpene alkaloid lappaconitine and pyrimidine fragments are reported. One route takes place via first converting of lappaconitine to 1-ethynyl-lappaconitine, followed by the S
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::287a1174a63c1672c6051a4a2e7d998b
http://europepmc.org/articles/PMC7730767
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje