Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kirill Oxenoid"'
Autor:
Wadim L Matochko, Constantin Nelep, Weihsu C Chen, Stephanie Grauer, Karyn McFadden, Vicki Wilson, Kirill Oxenoid
Publikováno v:
Antibody Therapeutics
The most robust strategy in antibody discovery is the use of immunized animals and the ability to isolate and immortalize immune B-cells to hybridoma for further interrogation. However, capturing the full repertoire of an immunized animal is labor in
Autor:
Christy Ann Thomson, Bernd Gardill, Lawrence Tu, Jerry Huang, Filip Van Petegem, Kirill Oxenoid
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Multi-pass membrane proteins are important targets of biologic medicines. Given the inherent difficulties in working with membrane proteins, we sought to investigate the utility of membrane scaffold protein nanodiscs as a means of solubilizing membra
Autor:
Vamsi K. Mootha, Tanxing Cui, Andrew L. Markhard, Yao Cong, Ying Dong, Bo OuYang, Liangliang Kong, Yasemin Sancak, Kirill Oxenoid, Zhijun Liu, James J. Chou, Chan Cao, Zenon Grabarek
Publikováno v:
Nature
Mitochondria from many eukaryotic clades take up large amounts of calcium (Ca(2+)) via an inner membrane transporter called the uniporter. Transport by the uniporter is membrane potential dependent and sensitive to ruthenium red or its derivative Ru3
Autor:
Kirill Oxenoid, James J. Chou
Publikováno v:
Protein Science. 25:959-973
By nature of conducting ions, transporting substrates and transducing signals, membrane channels, transporters and receptors are expected to exhibit intrinsic conformational dynamics. It is therefore of great interest and importance to understand the
Autor:
James J. Chou, Kirill Oxenoid
Publikováno v:
Current Opinion in Structural Biology
Membrane channels, transporters and receptors constitute essential means for cells to maintain homeostasis and communicate with the surroundings. Investigation of their molecular architecture and the dynamic process of transporting substrate or trans
Autor:
Kirill, Oxenoid, James J, Chou
Publikováno v:
Protein science : a publication of the Protein Society. 25(5)
By nature of conducting ions, transporting substrates and transducing signals, membrane channels, transporters and receptors are expected to exhibit intrinsic conformational dynamics. It is therefore of great interest and importance to understand the
Publikováno v:
Structure. 19:1655-1663
SummaryThe M2 channel of influenza A is a target of the adamantane family antiviral drugs. Two different drug-binding sites have been reported: one inside the pore, and the other is a lipid-facing pocket. A previous study showed that a chimera of M2
Autor:
Kirill Oxenoid, James J. Chou
Publikováno v:
Proceedings of the National Academy of Sciences. 102:10870-10875
Contraction and relaxation of heart muscle cells is regulated by cycling of calcium between cytoplasm and sarcoplasmic reticulum. Human phospholamban (PLN), expressed in the sarcoplasmic reticulum membrane as a 30-kDa homopentamer, controls cellular
Publikováno v:
Protein science : a publication of the Protein Society. 16(9)
Human phospholamban (PLN), a 30 kDa homopentamer in the sarcoplasmic reticulum (SR) membrane, controls the magnitude of heart muscle contraction and relaxation by regulating the calcium pumping activity of the SR Ca(2+)-ATPase (SERCA). When PLN is no
Autor:
Charles D. Ellis, Murthy D. Karra, Changlin Tian, Charles R. Sanders, Kirill Oxenoid, Frank D. Sönnichsen, Jaison Jacob
The first steps toward undertaking an NMR structural study of a new protein is very often to purify the protein and then to acquire an HSQC or TROSY NMR spectrum, the quality of which is used to assess the feasibility of an NMR-based structural deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa377958ff84d9208c5e1b1de8a03da9
https://doi.org/10.1016/s0076-6879(05)94012-3
https://doi.org/10.1016/s0076-6879(05)94012-3