Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kirill Lukin"'
Autor:
Eric Punzalan, Jianchang Li, Philip E. Eaton, Jürgen Hain, Kirill Lukin, Richard Gilardi, Nobuhiro Kanomata
Publikováno v:
Journal of the American Chemical Society. 119:9591-9602
Nitro groups on alternate corners of cubane enhance the acidity of cubyl hydrogen (pKa ∼21) and provide sufficient activation for ready anion formation. The sodium salt of 1,3,5,7-tetranitrocubane reacts easily with electrophiles and leads thereby
Publikováno v:
Angewandte Chemie. 108:937-940
Autor:
Philip E. Eaton, Kirill Lukin
Publikováno v:
Journal of the American Chemical Society. 117:7652-7656
Autor:
Philip E. Eaton, Kirill Lukin
Publikováno v:
Journal of the American Chemical Society. 115:11370-11375
Amide activation for anion formation from properly located CH groups in triangulanes is shown to provide for stereospecific functionalization. Thus, treatment of exo amide 20a with (TMP) 2 Mg followed by CO 2 carboxylation leads to syn substitution i
Publikováno v:
ChemInform. 29
Publikováno v:
Angewandte Chemie International Edition in English. 35:866-868
Publikováno v:
Angewandte Chemie International Edition in English. 35:864-866
Publikováno v:
Angewandte Chemie. 108:940-942
Publikováno v:
Synfacts. 2010:0393-0393
A five-step synthesis of a TRPV1 receptor antagonist 1 is described. The key step involves a novel palladium-catalyzed amidation reaction of 4-chloro-1-methylindazole 8 with the benzyl urea 9 to form the unsymmetrically substituted urea 1.