Intra-Arterial Stem Cell Transplantation in Experimental Stroke in Rats: Real-Time MR Visualization of Transplanted Cells Starting With Their First Pass Through the Brain With Regard to the Therapeutic Action

Autor: Daria D. Namestnikova, Ilya L. Gubskiy, Veronica A. Revkova, Kirill K. Sukhinich, Pavel A. Melnikov, Anna N. Gabashvili, Elvira A. Cherkashova, Daniil A. Vishnevskiy, Victoria V. Kurilo, Veronica V. Burunova, Alevtina S. Semkina, Maxim A. Abakumov, Leonid V. Gubsky, Vladimir P. Chekhonin, Jan-Eric Ahlfors, Vladimir P. Baklaushev, Konstantin N. Yarygin

Publikováno v: Frontiers in Neuroscience, Vol 15 (2021)

Cell therapy is an emerging approach to stroke treatment with a potential to limit brain damage and enhance its restoration after the acute phase of the disease. In this study we tested directly reprogrammed neural precursor cells (drNPC) derived fro

Externí odkaz: https://doaj.org/article/e20d3d9a3979462891e03fc1d477a4a0

Cell Therapy of Stroke: Do the Intra-Arterially Transplanted Mesenchymal Stem Cells Cross the Blood–Brain Barrier?

Autor: Konstantin N. Yarygin, Daria D. Namestnikova, Kirill K. Sukhinich, Ilya L. Gubskiy, Alexander G. Majouga, Irina V. Kholodenko

Publikováno v: Cells, Vol 10, Iss 11, p 2997 (2021)

Animal model studies and first clinical trials have demonstrated the safety and efficacy of the mesenchymal stem cells’ (MSCs) transplantation in stroke. Intra-arterial (IA) administration looks especially promising, since it provides targeted cell

Externí odkaz: https://doaj.org/article/b7afa2ef486749e995d051deb9667305

Comparative study of the efficacy of intra-arterial and intravenous transplantation of human induced pluripotent stem cells-derived neural progenitor cells in experimental stroke.

Autor: Cherkashova E; Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russian Federation, Moscow, Russian Federation.; Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency of Russian Federation, Moscow, Russian Federation., Namestnikova D; Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russian Federation, Moscow, Russian Federation.; Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency of Russian Federation, Moscow, Russian Federation., Leonov G; Orekhovich Research Institute of Biomedical Chemistry of the Russian Academy of Sciences, Moscow, Russian Federation., Gubskiy I; Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russian Federation, Moscow, Russian Federation.; Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency of Russian Federation, Moscow, Russian Federation., Sukhinich K; Orekhovich Research Institute of Biomedical Chemistry of the Russian Academy of Sciences, Moscow, Russian Federation., Melnikov P; Serbsky Federal Medical Research Centre of Psychiatry and Narcology of the Ministry of Healthcare of Russian Federation, Moscow, Russian Federation., Chekhonin V; Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russian Federation, Moscow, Russian Federation.; Serbsky Federal Medical Research Centre of Psychiatry and Narcology of the Ministry of Healthcare of Russian Federation, Moscow, Russian Federation., Yarygin K; Orekhovich Research Institute of Biomedical Chemistry of the Russian Academy of Sciences, Moscow, Russian Federation.; Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian Federation, Moscow, Russian Federation., Goldshtein D; Research Centre for Medical Genetics, Moscow, Russian Federation., Salikhova D; Institute of Molecular and Cellular Medicine, Medical Institute, RUDN University, Moscow, Russian Federation.

Publikováno v: PeerJ [PeerJ] 2023 Nov 09; Vol. 11, pp. e16358. Date of Electronic Publication: 2023 Nov 09 (Print Publication: 2023).

Methodological aspects of MRI of transplanted superparamagnetic iron oxide-labeled mesenchymal stem cells in live rat brain.

Autor: Namestnikova D; Pirogov Russian National Research Medical University, Moscow, Russia., Gubskiy I; Pirogov Russian National Research Medical University, Moscow, Russia., Kholodenko I; Institute of Biomedical Chemistry, Moscow, Russia., Melnikov P; Pirogov Russian National Research Medical University, Moscow, Russia.; Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Moscow, Russia., Sukhinich K; Koltzov Institute of Developmental Biology, Moscow, Russia., Gabashvili A; Institute of Biomedical Chemistry, Moscow, Russia., Vishnevskiy D; Pirogov Russian National Research Medical University, Moscow, Russia., Soloveva A; Pirogov Russian National Research Medical University, Moscow, Russia., Abakumov M; Pirogov Russian National Research Medical University, Moscow, Russia.; National University of Science and Technology, Moscow, Russia., Vakhrushev I; Institute of Biomedical Chemistry, Moscow, Russia., Lupatov A; Institute of Biomedical Chemistry, Moscow, Russia., Chekhonin V; Pirogov Russian National Research Medical University, Moscow, Russia.; Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Moscow, Russia., Gubsky L; Pirogov Russian National Research Medical University, Moscow, Russia., Yarygin K; Institute of Biomedical Chemistry, Moscow, Russia.

Publikováno v: PloS one [PLoS One] 2017 Oct 19; Vol. 12 (10), pp. e0186717. Date of Electronic Publication: 2017 Oct 19 (Print Publication: 2017).