Solid dispersions of drugs in hyaluronan matrix: The role of the biopolymer in modulating drug activity in vivo

Autor: Kirill I. Shingel, Mikhail Selyanin, Felix Polyak, Mario C. Filion

Publikováno v: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2017, 39, pp.140-146. ⟨10.1016/j.jddst.2017.03.018⟩

International audience; It was demonstrated in this study that the treatment of physical mixtures of hyaluronic acid (HA) and oncology drugs raloxifene, letrozole, and irinotecan in solid state under shear stress and deformation induces amorphization

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33060a1c281b00e8c0373b0278c41ca7
https://doi.org/10.1016/j.jddst.2017.03.018

Current knowledge on biosynthesis, biological activity, and chemical modification of the exopolysaccharide, pullulan

Autor: Kirill I Shingel

Publikováno v: Carbohydrate research. 339(3)

The article presents an overview of the latest advances in investigations of the biosynthesis, molecular properties, and associated biological activity of pullulan. The literature survey on the pullulan biosynthesis is intended to illustrate how the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbf683092e65d94cb97e94b6f37a9841
https://pubmed.ncbi.nlm.nih.gov/15013381

Analysis of dextran and pullulan molecular fraction structure by the method of IR-spectroscopy

Autor: S. P. Firsov, Peter T. Petrov, Kirill I. Shingel, Valerij M. Tsarenkov, R. G. Zhbankov

Publikováno v: Spectroscopy of Biological Molecules: New Directions ISBN: 9789401059190

The polysaccharides dextran and pullulan find wide application as base for the production of stimulators of immune activity, inductors of interferon and blood-plasma substitutes.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::808d7db168679a318c9de5bef5978c99
https://doi.org/10.1007/978-94-011-4479-7_144