Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Kirill Gorshkov"'
Autor:
Mikhail Kanarskii, Julia Nekrasova, Ekaterina Kondratieva, Ilya Borisov, Elena Simenel, Yurii Sviryaev, Pranil Pradhan, Kirill Gorshkov, Alexander Shestopalov, Marina Petrova
Publikováno v:
Sleep Medicine: X, Vol 7, Iss , Pp 100101- (2024)
Annotation (Abstract): Aim: The aim of our study is to assess circadian rhythms in patients with chronic critical illness due to severe brain injury in intensive care unit by establishing the relation between melatonin and cortisol secretion, conside
Externí odkaz:
https://doaj.org/article/7eebc68b57e142608ef880450c14f4a1
Autor:
Miao Xu, Manisha Pradhan, Kirill Gorshkov, Jennifer D. Petersen, Min Shen, Hui Guo, Wei Zhu, Carleen Klumpp-Thomas, Sam Michael, Misha Itkin, Zina Itkin, Marco R. Straus, Joshua Zimmerberg, Wei Zheng, Gary R. Whittaker, Catherine Z. Chen
Publikováno v:
SLAS Discovery, Vol 27, Iss 2, Pp 86-94 (2022)
Effective small molecule therapies to combat the SARS-CoV-2 infection are still lacking as the COVID-19 pandemic continues globally. High throughput screening assays are needed for lead discovery and optimization of small molecule SARS-CoV-2 inhibito
Externí odkaz:
https://doaj.org/article/f90b163e74134d30a8498c4857c338e0
Autor:
Junjie Xu, Lin Ji, Yuelong Liang, Zhe Wan, Wei Zheng, Xiaomin Song, Kirill Gorshkov, Qiming Sun, Hui Lin, Xueyong Zheng, Jiang Chen, Ren-an Jin, Xiao Liang, Xiujun Cai
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-14 (2020)
Abstract Sorafenib is the first-line chemotherapeutic therapy for advanced hepatocellular carcinoma (HCC). However, sorafenib resistance significantly limits its therapeutic efficacy, and the mechanisms underlying resistance have not been fully clari
Externí odkaz:
https://doaj.org/article/9bb4353dda9e4f869b1aa1e0821f61b6
Autor:
Tamara Marín, Andrés E. Dulcey, Fabián Campos, Catalina de la Fuente, Mariana Acuña, Juan Castro, Claudio Pinto, María José Yañez, Cristian Cortez, David W. McGrath, Pablo J. Sáez, Kirill Gorshkov, Wei Zheng, Noel Southall, Maria Carmo-Fonseca, Juan Marugán, Alejandra R. Alvarez, Silvana Zanlungo
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Niemann-Pick type A (NPA) disease is a fatal lysosomal neurodegenerative disorder caused by the deficiency in acid sphingomyelinase (ASM) activity. NPA patients present severe and progressive neurodegeneration starting at an early age. Currently, the
Externí odkaz:
https://doaj.org/article/eb6e916b22f74d1d9c8a35fe82a6b24e
Autor:
Ying Fu, Juliana da Fonseca Rezende E Mello, Bryan D Fleming, Alex Renn, Catherine Z Chen, Xin Hu, Miao Xu, Kirill Gorshkov, Quinlin Hanson, Wei Zheng, Emily M Lee, Lalith Perera, Robert Petrovich, Manisha Pradhan, Richard T Eastman, Zina Itkin, Thomas B Stanley, Allen Hsu, Venkata Dandey, Kedar Sharma, William Gillette, Troy Taylor, Nitya Ramakrishnan, Shelley Perkins, Dominic Esposito, Eunkeu Oh, Kimihiro Susumu, Mason Wolak, Marc Ferrer, Matthew D Hall, Mario J Borgnia, Anton Simeonov
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0272364 (2022)
Neutralizing antibodies targeting the SARS-CoV-2 spike protein have shown a great preventative/therapeutic potential. Here, we report a rapid and efficient strategy for the development and design of SARS-CoV-2 neutralizing humanized nanobody construc
Externí odkaz:
https://doaj.org/article/f2f1ebb6cd9a4991a32d3546fa2987d7
Autor:
Brianna M. Brooks, Manisha Pradhan, Yu-Shan Cheng, Kirill Gorshkov, Atena Farkhondeh, Catherine Z. Chen, Jeanette Beers, Chengyu Liu, Karsten Baumgaertel, Steven Rodems, Wei Zheng
Publikováno v:
Stem Cell Research, Vol 54, Iss , Pp 102447- (2021)
Alagille syndrome (ALGS) is a rare autosomal dominant disorder caused by disruption of the Notch signaling pathway due to mutations in either JAGGED1 (JAG1) (ALGS type 1) or NOTCH2 (ALGS type 2). Loss of this signaling interferes with the development
Externí odkaz:
https://doaj.org/article/2f12baeebb87454e85e831c61b5e858d
Autor:
Brianna M. Brooks, Charles D. Yeh, Jeanette Beers, Chengyu Liu, Yu-Shan Cheng, Kirill Gorshkov, Jizhong Zou, Wei Zheng, Catherine Z. Chen
Publikováno v:
Stem Cell Research, Vol 53, Iss , Pp 102387- (2021)
Farber disease is an ultra-rare lysosomal storage disease. Mutations in the N-acylsphingosine amidohydrolase (ASAH1) gene, which encodes for the enzyme acid ceramidase (ACDase), cause ceramides to accumulate in the body. A human induced pluripotent s
Externí odkaz:
https://doaj.org/article/21065c45040d4145a00f1c144a7784bb
Autor:
Kirill Gorshkov, Ni Sima, Wei Sun, Billy Lu, Wei Huang, Jameson Travers, Carleen Klumpp-Thomas, Samuel G. Michael, Tuan Xu, Ruili Huang, Emily M. Lee, Xiaodong Cheng, Wei Zheng
Publikováno v:
Translational Oncology, Vol 12, Iss 3, Pp 441-452 (2019)
Heterogeneous response to chemotherapy is a major issue for the treatment of cancer. For most gynecologic cancers including ovarian, cervical, and placental, the list of available small molecule therapies is relatively small compared to options for o
Externí odkaz:
https://doaj.org/article/e373e75cdaf24232b5787dfac7788c08
Autor:
Shu Yang, Kirill Gorshkov, Emily M. Lee, Miao Xu, Yu-Shan Cheng, Nuo Sun, Ferri Soheilian, Natalia de Val, Guoli Ming, Hongjun Song, Hengli Tang, Wei Zheng
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
The 2015 to 2016 outbreak of Zika virus (ZIKV) infections in the Americas coincided with a dramatic increase in neurodevelopmental abnormalities, including fetal microcephaly, in newborns born to infected women. In this study, we observed mitochondri
Externí odkaz:
https://doaj.org/article/9b62b642d6664fefa85116988315a422
Autor:
Mylinh Vu, Rong Li, Amanda Baskfield, Billy Lu, Atena Farkhondeh, Kirill Gorshkov, Omid Motabar, Jeanette Beers, Guokai Chen, Jizhong Zou, Angela J. Espejo-Mojica, Alexander Rodríguez-López, Carlos J. Alméciga-Díaz, Luis A. Barrera, Xuntian Jiang, Daniel S. Ory, Juan J. Marugan, Wei Zheng
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 13, Iss 1, Pp 1-15 (2018)
Abstract Background Tay-Sachs disease (TSD) is a rare neurodegenerative disorder caused by autosomal recessive mutations in the HEXA gene on chromosome 15 that encodes β-hexosaminidase. Deficiency in HEXA results in accumulation of GM2 ganglioside,
Externí odkaz:
https://doaj.org/article/bca708979a86458480f946c7d0be405e