Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Kirill E Medvedev"'
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 2, p e1011586 (2024)
Protein structure prediction has now been deployed widely across several different large protein sets. Large-scale domain annotation of these predictions can aid in the development of biological insights. Using our Evolutionary Classification of Prot
Externí odkaz:
https://doaj.org/article/ab7c2e89564f49c885e7578d8ee788ba
Publikováno v:
Clinical Pathology, Vol 17 (2024)
The most critical step in the clinical diagnosis workflow is the pathological evaluation of each tumor sample. Deep learning is a powerful approach that is widely used to enhance diagnostic accuracy and streamline the diagnosis process. In our previo
Externí odkaz:
https://doaj.org/article/29a50be5aa72457cb45163381907d752
Autor:
Kirill E Medvedev, Anna V Savelyeva, Kenneth S Chen, Aditya Bagrodia, Liwei Jia, Nick V Grishin
Publikováno v:
Cancer Informatics, Vol 21 (2022)
Objective: Testicular germ cell tumors (TGCT) are the most common solid malignancy in adolescent and young men, with a rising incidence over the past 20 years. Overall, TGCTs are second in terms of the average life years lost per person dying of canc
Externí odkaz:
https://doaj.org/article/751fd8a7bb3a49669b1093a57121bf76
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 12, p e1007569 (2019)
Rossmann folds are ancient, frequently diverged domains found in many biological reaction pathways where they have adapted for different functions. Consequently, discernment and classification of their homologous relations and function can be complic
Externí odkaz:
https://doaj.org/article/8343d22d8d704b87b2f7caef1b4166b0
Publikováno v:
ACS Omega, Vol 6, Iss 24, Pp 15698-15707 (2021)
Externí odkaz:
https://doaj.org/article/205c328aa0d1435c82df8d16140e4b29
Publikováno v:
BMC Molecular and Cell Biology, Vol 20, Iss 1, Pp 1-11 (2019)
Abstract The manual classification of protein domains is approaching its 20th anniversary. ECOD is our mixed manual-automatic domain classification. Over time, the types of proteins which require manual curation has changed. Depositions with complex
Externí odkaz:
https://doaj.org/article/19c77f981dcd49a098355749d769b373
Autor:
Anna V. Savelyeva, Kirill E. Medvedev
Publikováno v:
3 Biotech. 13
Pathological evaluation of each tumor sample is the most crucial process in the clinical diagnosis workflow. Deep learning is a powerful approach that is widely used to increase accuracy and to simplify the diagnosis process. Previously we discovered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f01d2cd24df7749979da5488d4add30
https://doi.org/10.1101/2022.05.16.22275153
https://doi.org/10.1101/2022.05.16.22275153
Testicular germ cell tumors (TGCT) are the most common solid malignancy in adolescent and young men, with a rising incidence over the past 20 years. Overall, TGCTs are second in terms of the average life years lost per person dying of cancer, and cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97b24dc3f25d9b5be47540a34ac143a6
https://doi.org/10.1101/2022.04.25.489437
https://doi.org/10.1101/2022.04.25.489437
Autor:
Nick V. Grishin, Archana S. Bhat, Richard Dustin Schaeffer, Lisa N. Kinch, Kirill E. Medvedev
Publikováno v:
Curr Opin Struct Biol
Allosteric regulation of protein functions is ubiquitous in organismal biology, but the principles governing its evolution are not well understood. Here we discuss recent studies supporting the large-scale existence of latent allostery in ancestor pr