Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Kirill D. Nadezhdin"'
Autor:
Yury A. Trofimov, Nikolay A. Krylov, Alexander S. Minakov, Kirill D. Nadezhdin, Arthur Neuberger, Alexander I. Sobolevsky, Roman G. Efremov
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Structural biology is solving an ever-increasing number of snapshots of ion channel conformational ensembles. Deciphering ion channel mechanisms, however, requires understanding the ensemble dynamics beyond the static structures. Here, we pr
Externí odkaz:
https://doaj.org/article/d60561fe8a7241f995045ec3eea8ddd1
Autor:
Arthur Neuberger, Yury A. Trofimov, Maria V. Yelshanskaya, Jeffrey Khau, Kirill D. Nadezhdin, Lena S. Khosrof, Nikolay A. Krylov, Roman G. Efremov, Alexander I. Sobolevsky
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract The calcium-selective oncochannel TRPV6 is an important driver of cell proliferation in human cancers. Despite increasing interest of pharmacological research in developing synthetic inhibitors of TRPV6, natural compounds acting at this chan
Externí odkaz:
https://doaj.org/article/24770a8288e94d4a9af6eb8f2702c528
Autor:
Kirill D. Nadezhdin, Irina A. Talyzina, Aravind Parthasarathy, Arthur Neuberger, David X. Zhang, Alexander I. Sobolevsky
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Transient receptor potential (TRP) channel TRPV4 is a polymodal cellular sensor that responds to moderate heat, cell swelling, shear stress, and small-molecule ligands. It is involved in thermogenesis, regulation of vascular tone, bone homeo
Externí odkaz:
https://doaj.org/article/6cf09e61876547089414903f23c0c5fa
Autor:
Arthur Neuberger, Yury A. Trofimov, Maria V. Yelshanskaya, Kirill D. Nadezhdin, Nikolay A. Krylov, Roman G. Efremov, Alexander I. Sobolevsky
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Calcium-selective oncochannel TRPV6 is the major driver of cell proliferation in human cancers. While significant effort has been invested in the development of synthetic TRPV6 inhibitors, natural channel blockers have been largely neglected
Externí odkaz:
https://doaj.org/article/29b1ef5c13944975bcd13acba4c2a4f9
Autor:
Kirill D. Nadezhdin, Leonor Correia, Chamali Narangoda, Dhilon S. Patel, Arthur Neuberger, Thomas Gudermann, Maria G. Kurnikova, Vladimir Chubanov, Alexander I. Sobolevsky
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The transient receptor potential channel TRPM7 is a master regulator of the organismal balance of divalent cations that plays an essential role in embryonic development, immune responses, cell mobility, proliferation, and differentiation. TR
Externí odkaz:
https://doaj.org/article/10950d54d07f4df59e7a501475b99298
Autor:
Arthur Neuberger, Mai Oda, Yury A. Nikolaev, Kirill D. Nadezhdin, Elena O. Gracheva, Sviatoslav N. Bagriantsev, Alexander I. Sobolevsky
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Pain therapy has remained conceptually stagnant since the opioid crisis, which highlighted the dangers of treating pain with opioids. An alternative addiction-free strategy to conventional painkiller-based treatment is targeting receptors at
Externí odkaz:
https://doaj.org/article/877e76e36dfb4876a5ee47fd8b5baa33
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
TRPV3 mediates cutaneous sensations such as itch and pain. Here authors present the cryo-EM structure of TRPV3 bound with local anesthetic which binds the channel in membrane portals that connect the membrane environment to the channel pore.
Externí odkaz:
https://doaj.org/article/094b5acee7a94109b8750bb873c62838
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
TRPV6 is a calcium-selective ion channel that is involved in numerous calcium-dependent physiological processes and it is of interest as a potential drug target. Here, the authors present the cryo-EM structures of human TRPV6 with the bound inhibitor
Externí odkaz:
https://doaj.org/article/c655b2e004b0428cb1826694f8cb395f
Autor:
Kirill D. Nadezhdin, Arthur Neuberger, Yury A. Nikolaev, Lyle A. Murphy, Elena O. Gracheva, Sviatoslav N. Bagriantsev, Alexander I. Sobolevsky
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Structural and functional characterization of the full-length TRPV1 channel from the thirteen-lined ground squirrel reveal the architecture of the extracellular cap domain and the intracellular C-terminus, and suggest a role of the cap domain in TRPV
Externí odkaz:
https://doaj.org/article/c4fde09e03ba45fbaf81d692cd390f1c
Autor:
Sergey A. Goncharuk, Lilya E. Artemieva, Kirill D. Nadezhdin, Alexander S. Arseniev, Konstantin S. Mineev
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Abstract The neurotrophin receptor p75NTR plays crucial roles in neuron development and regulates important neuronal processes like degeneration, apoptosis and cell survival. At the same time the detailed mechanism of signal transduction is unclear.
Externí odkaz:
https://doaj.org/article/93e81a0ed52f4a949f2c31ba9f7ec4c9