Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Kirill Batmanov"'
Autor:
Tsunehisa Yamamoto, Santosh K. Maurya, Elizabeth Pruzinsky, Kirill Batmanov, Yang Xiao, Sarah M. Sulon, Tomoya Sakamoto, Yang Wang, Ling Lai, Kendra S. McDaid, Swapnil V. Shewale, Teresa C. Leone, Timothy R. Koves, Deborah M. Muoio, Pieterjan Dierickx, Mitchell A. Lazar, E. Douglas Lewandowski, Daniel P. Kelly
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 9 (2023)
During the development of heart failure (HF), the capacity for cardiomyocyte (CM) fatty acid oxidation (FAO) and ATP production is progressively diminished, contributing to pathologic cardiac hypertrophy and contractile dysfunction. Receptor-interact
Externí odkaz:
https://doaj.org/article/73b6b8d5e2734d2b968b0ca4b0b2ae53
Autor:
Tomoya Sakamoto, Kirill Batmanov, Shibiao Wan, Yuanjun Guo, Ling Lai, Rick B. Vega, Daniel P. Kelly
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Mature cardiac muscle requires high mitochondrial ATP production and specialized contractile proteins. Here the authors demonstrate that cardiomyocyte-specific contractile maturation involves cooperation between the nuclear receptor ERRγ and cardiog
Externí odkaz:
https://doaj.org/article/f5e7d50ab66f4fc694608d2b029ad0f6
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract The contribution of mutations in regulatory regions to tumorigenesis has been the subject of many recent studies. We propose a new framework for integrative analysis of genome-wide sequencing data by considering diverse genetic information.
Externí odkaz:
https://doaj.org/article/a3a553a85191441ab02a874e256af4f6
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Most of somatic mutations in cancer occur outside of gene coding regions. These mutations may disrupt the gene regulation by affecting protein-DNA interaction. A study of these disruptions is important in understanding tumorigenesis. However, current
Externí odkaz:
https://doaj.org/article/e436110b215e4be89699cae203aeade0
Autor:
Yang Xiao, Kirill Batmanov, Wenxiang Hu, Kun Zhu, Alexander Y. Tom, Dongyin Guan, Chunjie Jiang, Lan Cheng, Sam J. McCright, Eric C. Yang, Matthew R. Lanza, Yifan Liu, David A. Hill, Mitchell A. Lazar
Publikováno v:
Science Translational Medicine. 15
Current therapeutic strategies for treating nonalcoholic steatohepatitis (NASH) have failed to alleviate liver fibrosis, which is a devastating feature leading to hepatic dysfunction. Here, we integrated single-nucleus transcriptomics and epigenomics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03ec5b9fa8bfe679f9f73e8f747f49c9
https://doi.org/10.1126/scitranslmed.adc9653
https://doi.org/10.1126/scitranslmed.adc9653
Autor:
Hannah J. Richter, Amy K. Hauck, Kirill Batmanov, Shin-Ichi Inoue, Bethany N. So, Mindy Kim, Matthew J. Emmett, Ronald N. Cohen, Mitchell A. Lazar
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Brown adipose tissue (BAT) is a key thermogenic organ whose expression of uncoupling protein 1 (UCP1) and ability to maintain body temperature in response to acute cold exposure require histone deacetylase 3 (HDAC3). HDAC3 exists in tight association
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce165f4221e30ffdd814a40b1237b086
https://doi.org/10.1073/pnas.2205276119
https://doi.org/10.1073/pnas.2205276119
Autor:
Katalin Susztak, Michelangella N. Arbocco, Chihiro Okada, Yu-Hua Tseng, Rojesh Shrestha, Matthew D. Lynes, Lan Cheng, Kirill Batmanov, Patrick Seale, Alexander P. Sakers, Corey D. Holman, Lucy Liaw, Farnaz Shamsi, Anthony R. Angueira
Publikováno v:
Nature Metabolism. 3:469-484
Brown adipose tissue can expend large amounts of energy, and therefore increasing its size or activity is a promising therapeutic approach to combat metabolic disease. In humans, major deposits of brown fat cells are found intimately associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::038754889ae0d83a0633f075cb6306a2
https://doi.org/10.1038/s42255-021-00380-0
https://doi.org/10.1038/s42255-021-00380-0
A coregulator shift, rather than the canonical switch, underlies thyroid hormone action in the liver
Autor:
Douglas Forrest, Young Wook Cho, Yehuda Shabtai, Kirill Batmanov, Yuxia Guan, Jarrett R. Remsberg, Nagaswaroop K. Nagaraj, Chunjie Jiang, Mitchell A. Lazar
Publikováno v:
Genes Dev
Thyroid hormones (THs) are powerful regulators of metabolism with major effects on body weight, cholesterol, and liver fat that have been exploited pharmacologically for many years. Activation of gene expression by TH action is canonically ascribed t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8dbc810a740dad200c7df144d18e3f5
https://doi.org/10.1530/ey.18.3.2
https://doi.org/10.1530/ey.18.3.2
Autor:
Santosh K. Maurya, Yang Xiao, Teresa C. Leone, Kendra McDaid, E Douglas D Lewandowski, Kirill Batmanov, Daniel P. Kelly, Tsunehisa Yamamoto, Swapnil V. Shewale, Elizabeth Pruzinsky
Publikováno v:
Circulation Research. 129
During the development of heart failure (HF), the PPAR/ERR complex becomes deactivated resulting in diminished capacity for mitochondrial fatty acid oxidation (FAO) and ATP production leading to an “energy-starved” state that contributes to progr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93a7ecbab4afc242df3ac33b9557c3db
https://doi.org/10.1161/res.129.suppl_1.113
https://doi.org/10.1161/res.129.suppl_1.113
Publikováno v:
Circulation Research. 127
During transition from fetal to adult developmental stages, the heart undergoes robust mitochondrial biogenesis in parallel with growth and structural maturation. Recently we identified a role for ERRα/γ in this broad program of postnatal cardiac m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a37858ff0e98c391067051ec0ea5794f
https://doi.org/10.1161/res.127.suppl_1.222
https://doi.org/10.1161/res.127.suppl_1.222