Výsledky vyhledávání - "Kiril, Chtraklin"

Akademický článek

Development of a large animal model of lethal polytrauma and intra-abdominal sepsis with bacteremia

Autor: Ben E Biesterveld, Umar F Bhatti, Aaron M Williams, Yongqing Li, Hasan B Alam, Michael T Kemp, Rachel L O'Connell, Glenn K Wakam, Ali Siddiqui, Nathan Graham, Kiril Chtraklin, Alizeh Shamshad

Publikováno v: Trauma Surgery & Acute Care Open, Vol 6, Iss 1 (2021)

Background Trauma and sepsis are individually two of the leading causes of death worldwide. When combined, the mortality is greater than 50%. Thus, it is imperative to have a reproducible and reliable animal model to study the effects of polytrauma a

Externí odkaz: https://doaj.org/article/5bdfe70f8fc2480882ba381daa239443

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Recombinant human MG53 protein attenuates brain lesion size in a large animal model of traumatic brain injury

Autor: Guang, Jin, Jessie W, Ho, Toby Philip, Keeney-Bonthrone, Rebecca Ariel, Ober, Baoling, Liu, Kiril, Chtraklin, Xiao-Liang, Wang, Xinyu, Zhou, Chuanxi, Cai, Yongqing, Li, Tao, Tan, Jianjie, Ma, Hasan B, Alam

Publikováno v: Journal of Trauma and Acute Care Surgery. 93:613-619

MG53, a member of the tripartite motif (TRIM) protein family, plays an essential role in cell membrane repair and promotes cell survival. Recent studies show that systemic delivery of recombinant human MG53 (rhMG53) protein markedly attenuates tissue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a157ebddd81c8f6c334302c91845e0
https://doi.org/10.1097/ta.0000000000003746

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A single dose of valproic acid improves neurologic recovery and decreases brain lesion size in swine subjected to an isolated traumatic brain injury

Autor: Krishani K. Rajanayake, Hasan B. Alam, Glenn K. Wakam, Claire A Vercruysse, Rachel L. O'Connell, Ben E. Biesterveld, Manjunath P. Pai, Michael T. Kemp, Kiril Chtraklin

Publikováno v: J Trauma Acute Care Surg

BACKGROUND We lack specific treatments for traumatic brain injury (TBI), which remains the leading cause of trauma-related morbidity and mortality. Treatment with valproic acid (VPA) improves outcomes in models of severe TBI with concurrent hemorrhag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae7accbca3ebd2c715fbed7ce80cb38e
https://doi.org/10.1097/ta.0000000000003136

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Histone deacetylase 6 inhibition improves survival in a swine model of lethal hemorrhage, polytrauma, and bacteremia

Autor: Michael T. Kemp, Hasan B. Alam, Kiril Chtraklin, Aaron M. Williams, Ben E. Biesterveld, Rachel L. O'Connell, Umar F. Bhatti, Glenn K. Wakam, Yongqing Li, Alizeh Shamshad, Ali Z. Siddiqui

Publikováno v: Journal of Trauma and Acute Care Surgery. 89:932-939

Background Trauma is the leading cause of death for young Americans. Nonspecific histone deacetylase inhibitors, such as valproic acid, have been shown to improve survival in preclinical models of lethal trauma, hemorrhage, and sepsis. The doses need

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::178da7fb0812e76269e2009018d82bb3
https://doi.org/10.1097/ta.0000000000002677

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Early single-dose exosome treatment improves neurologic outcomes in a 7-day swine model of traumatic brain injury and hemorrhagic shock

Autor: Umar F. Bhatti, Zhenyu Wu, Claire A Vercruysse, Yuzi Tian, Glenn K. Wakam, Yongqing Li, Simone E. Dekker, Hasan B. Alam, Ali Z. Siddiqui, Benjamin Buller, Zachary Pickell, Aaron M. Williams, Baoling Liu, Michael T. Kemp, Kiril Chtraklin, Ben E. Biesterveld

Publikováno v: Journal of Trauma and Acute Care Surgery. 89:388-396

BACKGROUND Early single-dose treatment with human mesenchymal stem cell-derived exosomes promotes neuroprotection and promotes blood-brain barrier integrity in models of traumatic brain injury (TBI) and hemorrhagic shock (HS) in swine. The impact of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a8de43495558508b534c8b3fe936b8
https://doi.org/10.1097/ta.0000000000002698

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Early single-dose treatment with exosomes provides neuroprotection and improves blood-brain barrier integrity in swine model of traumatic brain injury and hemorrhagic shock

Autor: Ranganath G. Kathawate, Gerald A. Higgins, Ben E. Biesterveld, Ali Z. Siddiqui, Benjamin Buller, Hasan B. Alam, Umar F. Bhatti, Nathan J. Graham, Jordana F. Brown, Anuska V. Andjelkovic, Aaron M. Williams, Simone E. Dekker, Kiril Chtraklin

Publikováno v: Journal of Trauma and Acute Care Surgery. 88:207-218

BACKGROUND Administration of human mesenchymal stem cell (MSC)-derived exosomes can enhance neurorestoration in models of traumatic brain injury (TBI) and hemorrhagic shock (HS). The impact of early treatment with MSC-derived exosomes on brain injury

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc4f177190b7dce95adb4755ce7ea147
https://doi.org/10.1097/ta.0000000000002563

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Dose optimization of valproic acid in a lethal model of traumatic brain injury, hemorrhage, and multiple trauma in swine

Autor: Umar F. Bhatti, Isabel S. Dennahy, Nathan J. Graham, Yongqing Li, Rachel M. Russo, Kiril Chtraklin, Manjunath P. Pai, Aaron M. Williams, Rachel L OʼConnell, Baoling Liu, Hasan B. Alam, Ali Z. Siddiqui, Ben E. Biesterveld

Publikováno v: Journal of Trauma and Acute Care Surgery. 87:1133-1139

BACKGROUND Trauma is a leading cause of death, and traumatic brain injury is one of the hallmark injuries of current military conflicts. Valproic acid (VPA) administration in high doses (300-400 mg/kg) improves survival in lethal trauma models, but e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b41694d270413614a0b331a5535b8cba
https://doi.org/10.1097/ta.0000000000002460

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Traumatic brain injury may worsen clinical outcomes after prolonged partial resuscitative endovascular balloon occlusion of the aorta in severe hemorrhagic shock model

Autor: Jing Zhou, Kiril Chtraklin, Vahagn C. Nikolian, Isabel S. Dennahy, Panpan Chang, Umar F. Bhatti, Nathan J. Graham, Aaron M. Williams, Ben E. Biesterveld, Hasan B. Alam, Jonathan L. Eliason

Publikováno v: Journal of Trauma and Acute Care Surgery. 86:415-423

BACKGROUND: The use of partial resuscitative endovascular balloon occlusion of the aorta (pREBOA) in combined hemorrhagic shock (HS) and traumatic brain injury (TBI) has not been well studied. We hypothesized that the use of pREBOA in the setting of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfe370b8d270d99ed793d91e0062afeb
https://doi.org/10.1097/ta.0000000000002149

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Isoform 6–selective histone deacetylase inhibition reduces lesion size and brain swelling following traumatic brain injury and hemorrhagic shock

Autor: Mohamed H. Ghandour, Michael Weykamp, Hasan B. Alam, Hassan Eidy, Isabel S. Dennahy, Kiril Chtraklin, Yongqing Li, Vahagn C. Nikolian, Aaron M. Williams, Umar F. Bhatti

Publikováno v: Journal of Trauma and Acute Care Surgery. 86:232-239

Nonselective histone deacetylase (pan-HDAC) inhibitors, such as valproic acid (VPA), have demonstrated neuroprotective properties in trauma models. However, isoform-specific HDAC inhibitors may provide opportunity for more effective drug administrati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b6a49083a3ec96375784986a46e27ec
https://doi.org/10.1097/ta.0000000000002119

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