Výsledky vyhledávání - "Kiriko Hiraoka"

Akademický článek

Depletion of runt-related transcription factor 2 (RUNX2) enhances SAHA sensitivity of p53-mutated pancreatic cancer cells through the regulation of mutant p53 and TAp63.

Autor: Takehiro Ogata, Mizuyo Nakamura, Meijie Sang, Hiroyuki Yoda, Kiriko Hiraoka, Danjing Yin, Mexiang Sang, Osamu Shimozato, Toshinori Ozaki

Publikováno v: PLoS ONE, Vol 12, Iss 7, p e0179884 (2017)

Suberoylanilide hydroxamic acid (SAHA) represents one of the new class of anti-cancer drugs. However, multiple lines of clinical evidence indicate that SAHA might be sometimes ineffective on certain solid tumors including pancreatic cancer. In this s

Externí odkaz: https://doaj.org/article/baa09445473d44f690347ae8215e726f

Zobrazit plný text záznamu

Akademický článek

Identification of Binding Targets of a Pyrrole-Imidazole Polyamide KR12 in the LS180 Colorectal Cancer Genome.

Autor: Jason Lin, Kiriko Hiraoka, Takayoshi Watanabe, Tony Kuo, Yoshinao Shinozaki, Atsushi Takatori, Nobuko Koshikawa, Anandhakumar Chandran, Joe Otsuki, Hiroshi Sugiyama, Paul Horton, Hiroki Nagase

Publikováno v: PLoS ONE, Vol 11, Iss 10, p e0165581 (2016)

Pyrrole-imidazole polyamides are versatile DNA minor groove binders and attractive therapeutic options against oncological targets, especially upon functionalization with an alkylating agent such as seco-CBI. These molecules also provide an alternati

Externí odkaz: https://doaj.org/article/6ddeaa21b84b42e0834e8733972bd6ff

Zobrazit plný text záznamu

Targeting the mutant PIK3CA gene by DNA‐alkylating pyrrole‐imidazole polyamide in cervical cancer

Autor: Hiroyuki Yoda, Jason Lin, Takayoshi Watanabe, Nobuko Koshikawa, Atsushi Takatori, Takahiro Inoue, Hiroki Nagase, Sakthisri Krishnamurthy, Yoshinao Shinozaki, Kiriko Hiraoka

Publikováno v: Cancer Science

PIK3CA is the most frequently mutated oncogene in cervical cancer, and somatic mutations in the PIK3CA gene result in increased activity of PI3K. In cervical cancer, the E545K mutation in PIK3CA leads to elevated cell proliferation and reduced apopto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaa96551b546b48f72aabcd8659aebd9
http://europepmc.org/articles/PMC7935806

Zobrazit plný text záznamu

Depletion of pro-oncogenic RUNX2 enhances gemcitabine (GEM) sensitivity of p53-mutated pancreatic cancer Panc-1 cells through the induction of pro-apoptotic TAp63

Autor: Kiriko Hiraoka, Meijie Sang, Osamu Shimozato, Takehiro Ogata, Mizuyo Nakamura, Hiroyuki Yoda, Meixiang Sang, Toshinori Ozaki

Publikováno v: Oncotarget

// Toshinori Ozaki 1 , Mizuyo Nakamura 1 , Takehiro Ogata 1 , Meijie Sang 1, 2 , Hiroyuki Yoda 3 , Kiriko Hiraoka 3 , Meixiang Sang 1, 4 , Osamu Shimozato 1 1 Laboratory of DNA Damage Signaling, Chiba Cancer Center Research Institute, Chiba, Japan 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0186299254c886abaf22c574c4102640
http://europepmc.org/articles/PMC5342134

Zobrazit plný text záznamu

Depletion of runt-related transcription factor 2 (RUNX2) enhances SAHA sensitivity of p53-mutated pancreatic cancer cells through the regulation of mutant p53 and TAp63

Autor: Mexiang Sang, Osamu Shimozato, Hiroyuki Yoda, Meijie Sang, Toshinori Ozaki, Danjing Yin, Kiriko Hiraoka, Mizuyo Nakamura, Takehiro Ogata

Publikováno v: PLoS ONE
PLoS ONE, Vol 12, Iss 7, p e0179884 (2017)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::398877f060347fea20d471da8c63562e
http://europepmc.org/articles/PMC5495219

Zobrazit plný text záznamu

Autor: Mizuyo Nakamura, Hiroki Nagase, Kyoko Fujiwara, Kiriko Hiraoka, Toshinori Ozaki, Hirokazu Sugimoto, Meixiang Sang, Hiroyuki Yoda

Publikováno v: The Febs Journal

Although runt-related transcription factor 2 (RUNX2) is known to be an essential key transcription factor for osteoblast differentiation and bone formation, RUNX2 also plays a pivotal role in the regulation of p53-dependent DNA damage response. In th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6786a92416d4bb624324e3585cc4ba2
https://doi.org/10.1111/febs.13108

Zobrazit plný text záznamu

Identification, expression, and molecular evolution of microRNAs in the 'living fossil' Triops cancriformis (tadpole shrimp)

Autor: Kiriko Hiraoka, Kahori T. Ikeda, Akio Kanai, Kosuke Fujishima, Yuka Hirose, Emiko Noro, Masaru Tomita

MicroRNAs have been identified and analyzed in various model species, but an investigation of miRNAs in nonmodel species is required for a more complete understanding of miRNA evolution. In this study, we investigated the miRNAs of the nonmodel speci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e8190053a33cd3533a0ab10f3fb468f
https://europepmc.org/articles/PMC4338350/

Zobrazit plný text záznamu

Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole-imidazole polyamide conjugate

Autor: Hirokazu Sugimoto, Yoshiaki Maru, Atsushi Takatori, Hiroki Nagase, Toshikazu Bando, Tadamichi Denda, Takayoshi Watanabe, Kyoko Fujiwara, Nobuko Koshikawa, Allan Balmain, Hiroyuki Yoda, Takahiro Inoue, Hiroshi Sugiyama, Kiriko Hiraoka, Toshinori Ozaki, Ken-ichi Shinohara, Rhys Dylan Taylor

Publikováno v: Nature communications. 6

Despite extensive efforts to target mutated RAS proteins, anticancer agents capable of selectively killing tumour cells harbouring KRAS mutations have remained unavailable. Here we demonstrate the direct targeting of KRAS mutant DNA using a synthetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0628c489fb56239539d434675865b8d6
https://pubmed.ncbi.nlm.nih.gov/25913614

Zobrazit plný text záznamu

Identification of Binding Targets of a Pyrrole-Imidazole Polyamide KR12 in the LS180 Colorectal Cancer Genome

Autor: Tony Kuo, Joe Otsuki, Hiroshi Sugiyama, Atsushi Takatori, Takayoshi Watanabe, Jason Lin, Hiroki Nagase, Anandhakumar Chandran, Nobuko Koshikawa, Paul Horton, Yoshinao Shinozaki, Kiriko Hiraoka

Publikováno v: PLoS ONE
PLoS ONE, Vol 11, Iss 10, p e0165581 (2016)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb6082d85ee91f66c9d03bce44a38f81
https://doi.org/10.1371/journal.pone.0165581

Zobrazit plný text záznamu

Abstract 3775: Mutated cancer cell-specific cell death activity of alkylating Pyrrole-Imidazole polyamide conjugates targeting a variety of oncogenic driver gene mutations

Autor: Nobuko Koshikawa, Jason Lin, Kiriko Hiraoka, Krishnamurthy Sakthisri, Takayoshi Watanabe, Hiroyuki Yoda, Hiroki Nagase, Atsushi Takatori, Takahiro Inoue

Publikováno v: Cancer Research. 76:3775-3775

Cancer may be recognized as non-self by antibiotics such as minor groove binders, which show self / non-self recognition partially due to preferential DNA sequence recognition and distinguish from other non-self bacteria. We learned minor groove bind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b00c9a241b73bc5bed126bced5075715
https://doi.org/10.1158/1538-7445.am2016-3775

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání