Zobrazeno 1 - 10 of 128 pro vyhledávání: '"Kiriakidis S"'
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Akademický článek
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2
Aetiopathology of rheumatoid arthritis
Autor: Taylor, PC, Kiriakidis, S
Rheumatoid arthritis (RA) has a multifactorial aetiopathogenesis with both genetic and environmental factors implicated, giving rise to immune dysregulation with resultant joint inflammation and tissue damage. The emergence of biologic and small mole
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7e398823afad8e30f8451e1152a7b6a
https://doi.org/10.1016/j.mpmed.2021.12.001
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3
The JAK inhibitor baricitinib inhibits oncostatin M induction of proinflammatory mediators in ex-vivo synovial derived cells
Autor: Weston, S, Macdonald, JL, Williams, LM, Roussou, E, Kang, NV, Kiriakidis, S, Taylor, PC
Publikováno v: Clinical and experimental rheumatology. 40(9)
Objectives: To investigate the ex vivo effect of the JAK1/2 inhibitor baricitinib on expression of pro-inflammatory mediators in rheumatoid arthritis (RA) fibroblast like synoviocytes (FLS) stimulated with TNFα, IL-1β and oncostatin M (OSM), and in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c753bf955bcad81375c6e3224d04cbd
https://pubmed.ncbi.nlm.nih.gov/34665696
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4
Akademický článek
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5
Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase, and is sensitive to off target inhibition by prolyl hydroxylase domain inhibitors that stabilise Hypoxia Inducible Factor
Autor: Kiriakidis, S, Hoer, SS, Burrows, N, Biddlecome, G, Khan, MN, Thinnes, CC, Schofield, CJ, Rogers, N, Botto, M, Paleolog, E, Maxwell, PH
Publikováno v: Kidney International
C1q is part of the C1 macromolecular complex that mediates the classical complement activation pathway, a major arm of innate immune defence. C1q is composed of A, B, and C chains that require post-translational prolyl-4-hydroxylation of their N-term
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::aafa03069cf585cf50fbe586cffc9787
https://ora.ox.ac.uk/objects/uuid:04b6cb9c-ef1b-4569-b5b4-0aaba4762379
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7
Vascular endothelium--role in chronic inflammatory disease
Autor: Kiriakidis, S, Paleolog, EM
The vascular endothelial lining of blood vessels plays a key 'target-effector' role in vivo, integrating the body's response to inflammatory cytokines, chemokines and growth factors (derived from both endothelial cells themselves and from other cells
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::98f29a286eeba74ad878e0bdb3dac001
https://ora.ox.ac.uk/objects/uuid:4d9b1d8b-ce50-46bf-869a-1a798d4ef1f6
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8
VEGF expression in human macrophages is NF-kappaB-dependent: studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2
Autor: Kiriakidis, S, Andreakos, E, Monaco, C, Foxwell, B, Feldmann, M, Paleolog, E
Vascular endothelial growth factor (VEGF) is the most endothelial cell-specific angiogenic factor characterised to date, and it is produced by a variety of cell types. In macrophages, VEGF has been shown to be upregulated by the inflammatory mediator
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::832bfc4e4ba04772dbbc056c30223737
https://ora.ox.ac.uk/objects/uuid:85dd6cea-e786-499c-909d-64c41ba5333f
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