Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Alterations in the gut microbiome implicate key taxa and metabolic pathways across inflammatory arthritis phenotypes.

Autor: Thompson KN; Department of Biostatistics, T. H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA.; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Harvard Chan Microbiome in Public Health Center, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA., Bonham KS; Department of Biostatistics, T. H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA.; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Ilott NE; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedic, Rheumatology and Musculoskeletal Sciences, Oxford University, Oxford OX3 7FY, UK., Britton GJ; Marc and Jennifer Lipschultz Precision Immunology Institute and Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Colmenero P; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedic, Rheumatology and Musculoskeletal Sciences, Oxford University, Oxford OX3 7FY, UK., Bullers SJ; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedic, Rheumatology and Musculoskeletal Sciences, Oxford University, Oxford OX3 7FY, UK., McIver LJ; Department of Biostatistics, T. H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA.; Harvard Chan Microbiome in Public Health Center, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA., Ma S; Department of Biostatistics, T. H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA.; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Nguyen LH; Department of Biostatistics, T. H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA.; Harvard Chan Microbiome in Public Health Center, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA., Filer A; Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TT, UK.; MRC Versus Arthritis Centre for Musculoskeletal Ageing Research and Research Into Inflammatory Arthritis Centre Versus Arthritis, University of Birmingham, Chesterfield S41 7TD, UK., Brough I; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedic, Rheumatology and Musculoskeletal Sciences, Oxford University, Oxford OX3 7FY, UK.; Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, UK., Pearson C; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedic, Rheumatology and Musculoskeletal Sciences, Oxford University, Oxford OX3 7FY, UK., Moussa C; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedic, Rheumatology and Musculoskeletal Sciences, Oxford University, Oxford OX3 7FY, UK., Kumar V; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedic, Rheumatology and Musculoskeletal Sciences, Oxford University, Oxford OX3 7FY, UK., Lam LH; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedic, Rheumatology and Musculoskeletal Sciences, Oxford University, Oxford OX3 7FY, UK., Jackson MA; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedic, Rheumatology and Musculoskeletal Sciences, Oxford University, Oxford OX3 7FY, UK., Pawluk A; Department of Biostatistics, T. H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA.; Harvard Chan Microbiome in Public Health Center, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA., Kiriakidis S; Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, UK., Taylor PC; Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, UK., Wedderburn LR; Centre for Adolescent Rheumatology Versus Arthritis, University College London, UCLH, and GOSH, Chesterfield S41 7TD, UK.; NIHR Great Ormond Street Biomedical Research Centre, University College London, London WC1N 1EH, UK.; UCL GOS Institute of Child Health, University College London, London WC1N 1EH, UK., Marsden B; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedic, Rheumatology and Musculoskeletal Sciences, Oxford University, Oxford OX3 7FY, UK., Young SP; Department of Rheumatology, Sandwell & West Birmingham NHS Trust, West Bromwich B71 4HJ, UK., Littman DR; Howard Hughes Medical Institute and the Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA., Faith JJ; Marc and Jennifer Lipschultz Precision Immunology Institute and Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Pratt AG; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.; Research into Inflammatory Arthritis Centre Versus Arthritis, Newcastle Birmingham, Glasgow, and Oxford, Chesterfield S41 7TD, UK.; Department of Rheumatology, Musculoskeletal Services Directorate, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne NE7 7DN, UK., Bowness P; Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, UK., Raza K; Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TT, UK.; MRC Versus Arthritis Centre for Musculoskeletal Ageing Research and Research Into Inflammatory Arthritis Centre Versus Arthritis, University of Birmingham, Chesterfield S41 7TD, UK.; Department of Rheumatology, Sandwell & West Birmingham NHS Trust, West Bromwich B71 4HJ, UK., Powrie F; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedic, Rheumatology and Musculoskeletal Sciences, Oxford University, Oxford OX3 7FY, UK., Huttenhower C; Department of Biostatistics, T. H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA.; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Harvard Chan Microbiome in Public Health Center, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2023 Jul 26; Vol. 15 (706), pp. eabn4722. Date of Electronic Publication: 2023 Jul 26.

Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase, and is sensitive to off target inhibition by prolyl hydroxylase domain inhibitors that stabilise Hypoxia Inducible Factor

Autor: Kiriakidis, S, Hoer, SS, Burrows, N, Biddlecome, G, Khan, MN, Thinnes, CC, Schofield, CJ, Rogers, N, Botto, M, Paleolog, E, Maxwell, PH

Publikováno v: Kidney International

C1q is part of the C1 macromolecular complex that mediates the classical complement activation pathway, a major arm of innate immune defence. C1q is composed of A, B, and C chains that require post-translational prolyl-4-hydroxylation of their N-term

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::aafa03069cf585cf50fbe586cffc9787
https://ora.ox.ac.uk/objects/uuid:04b6cb9c-ef1b-4569-b5b4-0aaba4762379

Vascular endothelium--role in chronic inflammatory disease

Autor: Kiriakidis, S, Paleolog, EM

The vascular endothelial lining of blood vessels plays a key 'target-effector' role in vivo, integrating the body's response to inflammatory cytokines, chemokines and growth factors (derived from both endothelial cells themselves and from other cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::98f29a286eeba74ad878e0bdb3dac001
https://ora.ox.ac.uk/objects/uuid:4d9b1d8b-ce50-46bf-869a-1a798d4ef1f6

Factor inhibiting HIF (FIH-1) promotes renal cancer cell survival by protecting cells from HIF-1α-mediated apoptosis

Autor: Khan, M N, Bhattacharyya, T, Andrikopoulos, P, Esteban, M A, Barod, R, Connor, T, Ashcroft, M, Maxwell, P H, Kiriakidis, S

Publikováno v: British Journal of Cancer; Vol 104

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=ec_fp7health::07530fb5d0585baf8956e6eebfc58609