Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Kiri Honma"'
CD19(+) B cells confer protection against experimental cerebral malaria in semi-immune rodent model.
Autor:
Lam Quoc Bao, Nguyen Tien Huy, Mihoko Kikuchi, Tetsuo Yanagi, Masachika Senba, Mohammed Nasir Shuaibu, Kiri Honma, Katsuyuki Yui, Kenji Hirayama
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64836 (2013)
In African endemic area, adults are less vulnerable to cerebral malaria than children probably because of acquired partial immunity or semi-immune status. Here, we developed an experimental cerebral malaria (ECM) model for semi-immune mice. C57BL/6 (
Externí odkaz:
https://doaj.org/article/b3c95ebf85bf4bde932059fad7d09f97
Autor:
Kiri Honma, Toshifumi Matsuyama, Mana Miyakoda, Katsuyuki Yui, Kazumi Kimura, Daisuke Kimura, Masoud Akbari
Publikováno v:
European journal of immunology. 48(8)
Interferon regulatory factor 4 (IRF4) has critical roles in immune cell differentiation and function and is indispensable for clonal expansion and effector function in T cells. Here, we demonstrate that the AKT pathway is impaired in murine CD8+ T ce
Autor:
Kiri Honma, Katsuyuki Yui, Mana Miyakoda, Toshifumi Matsuyama, Daisuke Kimura, Kazumi Kimura, Masoud Akbari
Publikováno v:
The Journal of Immunology. 192:2271-2279
IRF4 is a transcription factor from the IRF factor family that plays pivotal roles in the differentiation and function of T and B lymphocytes. Although IRF4 is also expressed in dendritic cells (DCs) and macrophages, its roles in these cells in vivo
Autor:
Yoshifumi Matsushima, Katsuyuki Yui, Kiri Honma, Kazumi Kimura, Mana Miyakoda, Masao Yuda, Daisuke Kimura
Publikováno v:
Infection and Immunity. 81(10):3825-3834
Following Anopheles mosquito-mediated introduction into a human host, Plasmodium parasites infect hepatocytes and undergo intensive replication. Accumulating evidence indicates that CD8+ T cells induced by immunization with attenuated Plasmodium spor
Autor:
Kiri Honma, Kazumi Kimura, Katsuyuki Yui, Daisuke Kimura, Rika Kamei, Mana Miyakoda, Takahiko Tamura
Publikováno v:
Microbiology and Immunology. 57:213-223
The spleen is the main organ for immune defense during infection with Plasmodium parasites and splenomegaly is one of the major symptoms of such infections. Using a rodent model of Plasmodium yoelii infection, MHC class II(+)CD11c(-) non-T, non-B cel
Publikováno v:
The Journal of Immunology. 189:4396-4404
Conditions required for establishing protective immune memory vary depending on the infecting microbe. Although the memory immune response against malaria infection is generally thought to be relatively slow to develop and can be lost rapidly, experi
Autor:
Kiri Honma, Mana Miyakoda, Masao Yuda, Yasuo Chinzei, Daisuke Kimura, Yoshisada Shibata, Katsuyuki Yui
Publikováno v:
International Immunology. 22(12):941-952
T-cell immune responses are critical for protection of the host and for disease pathogenesis during infection with Plasmodium species. We examined the regulation of CD4+ T-cell cytokine responses during infection with Plasmodium berghei ANKA (PbA). C
Autor:
Kiri Honma, Kenta Nakai, Toshihiko Okazaki, Yoshiaki Tanaka, Tatsuya Saitoh, Shizuo Akira, Katsuyuki Yui, Toshifumi Matsuyama, Koubun Yasuda, Kenji Nakanishi, Tohru Miyake, Tohru Tsujimura, Alexis Vandenbon, Takashi Satoh, Osamu Takeuchi, Yutaro Kumagai, Daron M. Standley, Kazufumi Matsushita
Publikováno v:
Nature Immunology. 11:936-944
Polarization of macrophages to M1 or M2 cells is important for mounting responses against bacterial and helminth infections, respectively. Jumonji domain containing-3 (Jmjd3), a histone 3 Lys27 (H3K27) demethylase, has been implicated in the activati
Autor:
Atsushi Kumatori, Takashi Suematsu, Michio Nakamura, Kazuo Yamamoto, Katsuyuki Yui, Kazuo Suzuki, Toshifumi Matsuyama, Ichinose Akitoyo, Shoichi Suzuki, Kan Toriyama, Kiri Honma
Publikováno v:
Proceedings of the National Academy of Sciences. 101:8981-8986
IFN regulatory factors (IRFs) are a family of transcription factors that play an essential role in the homeostasis and function of immune systems. Recent studies indicated that IRF-8 is critical for the development of CD11blowCD8α+conventional dendr
Autor:
Heiichiro Udono, Hiroshi Mukae, Yuko Kawabata, Kiri Honma, Masakatsu Ueda, Shigeru Kohno, Katsuyuki Yui, Jun-ichi Kadota
Publikováno v:
Infection and Immunity. 70:6075-6082
One of the difficulties in developing an effective malaria vaccine is the antigenic change of the parasite during the life cycle. It is desirable that vaccine-induced protective immunity be effective at different stages of parasite development. Meroz