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A New Negative Allosteric Modulator AP14145 for the Study of Small Conductance Calcium-Activated Potassium Channels

Autor: Simo Vicens, Rafel, Kirchhoff, Jeppe Egedal, Dolce , Bernardo, Abildgaard, Lea, Speerschneider, Tobias, Sørensen, Ulrik Svane, Grunnet, Morten, Diness, Jonas Goldin, Bentzen, Bo Hjorth

Publikováno v: Simo Vicens, R, Kirchhoff, J E, Dolce, B, Abildgaard, L, Speerschneider, T, Sørensen, U S, Grunnet, M, Diness, J G & Bentzen, B H 2017, ' A New Negative Allosteric Modulator AP14145 for the Study of Small Conductance Calcium-Activated Potassium Channels ', British Journal of Pharmacology, vol. 174, no. 23, pp. 4396-4408 . https://doi.org/10.1111/bph.14043

Background and purpose: Small conductance Ca2+-activated K+ (KCa2) channels represent a promising atrial-selective target for treatment of atrial fibrillation (AF). Here, we establish the mechanism of KCa2 inhibition by the new compound AP14145.Exper

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2751::cb168382816c23b96c883f85f42cf05c
https://curis.ku.dk/portal/da/publications/a-new-negative-allosteric-modulator-ap14145-for-the-study-of-small-conductance-calciumactivated-potassium-channels(e0f00d5e-e696-49ff-a2e9-a90d4e0786c9).html

The KCa2 Channel Inhibitor AP14145, But Not Dofetilide or Ondansetron, Provides Functional Atrial Selectivity in Guinea Pig Hearts.

Autor: Kirchhoff, Jeppe Egedal, Skarsfeldt, Mark Alexander, Muthukumarasamy, Kalai Mangai, Simó-Vicens, Rafel, Bomholtz, Sofia Hammami, Abildgaard, Lea, Jespersen, Thomas, Sørensen, Ulrik S., Grunnet, Morten, Bentzen, Bo Hjorth, Diness, Jonas Goldin

Publikováno v: Frontiers in Pharmacology; 6/19/2019, pN.PAG-N.PAG, 13p

Lack of renoprotective effects by long-term PCSK9 and SGLT2 inhibition using alirocumab and empagliflozin in obese ZSF1 rats.

Autor: Hummelgaard S; Department of Biomedicine, Aarhus University, Denmark.; Department of Cardio-Renal Pharmacology, Novo Nordisk, Måløv, Denmark., Hvid H; Department of Pathology and Imaging, Novo Nordisk, Måløv, Denmark., Birn H; Department of Clinical Medicine and Renal Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark., Glerup S; Department of Biomedicine, Aarhus University, Denmark.; Draupnir Bio, c/o INCUBA Skejby, Aarhus, Denmark., Tom N; Lipidomics Core Facility, Danish Cancer Institute, Copenhagen, Denmark., Bilgin M; Lipidomics Core Facility, Danish Cancer Institute, Copenhagen, Denmark., Kirchhoff JE; Department of Cardio-Renal Pharmacology, Novo Nordisk, Måløv, Denmark., Weyer K; Department of Biomedicine, Aarhus University, Denmark.

Publikováno v: American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2024 Nov 18, pp. . Date of Electronic Publication: 2024 Nov 18.