Genetically encoded discovery of perfluoroaryl macrocycles that bind to albumin and exhibit extended circulation in vivo.

Autor: Wong JYK; Department of Chemistry, University of Alberta, Edmonton, AB, T6G 2G2, Canada., Ekanayake AI; Department of Chemistry, University of Alberta, Edmonton, AB, T6G 2G2, Canada., Kharchenko S; Department of Chemistry, University of Alberta, Edmonton, AB, T6G 2G2, Canada., Kirberger SE; Department of Chemistry, University of Minnesota, Minneapolis, MN, 55455, USA., Qiu R; Department of Chemistry, University of Alberta, Edmonton, AB, T6G 2G2, Canada., Kelich P; Department of Chemistry and Biochemistry, University of Texas at El Paso, El Paso, TX, 79968, USA., Sarkar S; Department of Chemistry, University of Alberta, Edmonton, AB, T6G 2G2, Canada., Li J; Department of Chemistry, University of Minnesota, Minneapolis, MN, 55455, USA., Fernandez KX; Department of Chemistry, University of Alberta, Edmonton, AB, T6G 2G2, Canada., Alvizo-Paez ER; Department of Chemistry, University of Alberta, Edmonton, AB, T6G 2G2, Canada., Miao J; Department of Chemistry, Tufts University, Medford, MA, 02155, USA., Kalhor-Monfared S; Department of Chemistry, University of Alberta, Edmonton, AB, T6G 2G2, Canada., John JD; Ferring Research Institute, San Diego, CA, 92121, USA., Kang H; Quantum Intelligence Corp., 31F, One IFC, 10 Gukjegeumyung-ro, Yeongdeungpo-gu-Seoul, Republic of Korea., Choi H; Quantum Intelligence Corp., 31F, One IFC, 10 Gukjegeumyung-ro, Yeongdeungpo-gu-Seoul, Republic of Korea., Nuss JM; Ferring Research Institute, San Diego, CA, 92121, USA., Vederas JC; Department of Chemistry, University of Alberta, Edmonton, AB, T6G 2G2, Canada., Lin YS; Department of Chemistry, Tufts University, Medford, MA, 02155, USA., Macauley MS; Department of Chemistry, University of Alberta, Edmonton, AB, T6G 2G2, Canada.; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, T6G 2E1, Canada., Vukovic L; Department of Chemistry and Biochemistry, University of Texas at El Paso, El Paso, TX, 79968, USA., Pomerantz WCK; Department of Chemistry, University of Minnesota, Minneapolis, MN, 55455, USA., Derda R; Department of Chemistry, University of Alberta, Edmonton, AB, T6G 2G2, Canada. ratmir@ualberta.ca.

Publikováno v: Nature communications [Nat Commun] 2023 Sep 13; Vol. 14 (1), pp. 5654. Date of Electronic Publication: 2023 Sep 13.

Autophagy-Dependent Sensitization of Triple-Negative Breast Cancer Models to Topoisomerase II Poisons by Inhibition of the Nucleosome Remodeling Factor.

Autor: Tyutyunyk-Massey L; VCU Massey Cancer Center, Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, Virginia., Sun Y; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, NIH, Bethesda, Maryland., Dao N; VCU Massey Cancer Center, Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia., Ngo H; VCU Massey Cancer Center, Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia., Dammalapati M; VCU Massey Cancer Center, Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia., Vaidyanathan A; VCU Massey Cancer Center, Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia., Singh M; VCU Massey Cancer Center, Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia., Haqqani S; VCU Massey Cancer Center, Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia., Haueis J; VCU Massey Cancer Center, Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia., Finnegan R; VCU Massey Cancer Center, Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, Virginia., Deng X; VCU Massey Cancer Center, Department of Biostatistics, Virginia Commonwealth University School of Medicine, Richmond, Virginia., Kirberger SE; Department of Chemistry, University of Minnesota, Minneapolis, Minnesota., Bos PD; VCU Massey Cancer Center, Department of Pathology, Virginia Commonwealth University School of Medicine, Richmond, Virginia., Bandyopadhyay D; VCU Massey Cancer Center, Department of Biostatistics, Virginia Commonwealth University School of Medicine, Richmond, Virginia., Pomerantz WCK; Department of Chemistry, University of Minnesota, Minneapolis, Minnesota., Pommier Y; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, NIH, Bethesda, Maryland., Gewirtz DA; VCU Massey Cancer Center, Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, Virginia., Landry JW; VCU Massey Cancer Center, Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia. joseph.landry@vcuhealth.org.

Publikováno v: Molecular cancer research : MCR [Mol Cancer Res] 2021 Aug; Vol. 19 (8), pp. 1338-1349. Date of Electronic Publication: 2021 Apr 02.

Efficient Synthesis of 1,4-Thiazepanones and 1,4-Thiazepanes as 3D Fragments for Screening Libraries.

Autor: Pandey AK; Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States., Kirberger SE; Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States., Johnson JA; Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States., Kimbrough JR; Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States., Partridge DKD; Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States., Pomerantz WCK; Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States.

Publikováno v: Organic letters [Org Lett] 2020 May 15; Vol. 22 (10), pp. 3946-3950. Date of Electronic Publication: 2020 Apr 29.

Evaluating the Advantages of Using 3D-Enriched Fragments for Targeting BET Bromodomains.

Autor: Johnson JA; Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States., Nicolaou CA; Discovery Chemistry Research & Technologies, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Kirberger SE; Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States., Pandey AK; Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States., Hu H; Discovery Chemistry Research & Technologies, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Pomerantz WCK; Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2019 Nov 22; Vol. 10 (12), pp. 1648-1654. Date of Electronic Publication: 2019 Nov 22 (Print Publication: 2019).

BPTF Maintains Chromatin Accessibility and the Self-Renewal Capacity of Mammary Gland Stem Cells.

Autor: Frey WD; Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA., Chaudhry A; Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA., Slepicka PF; Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA., Ouellette AM; Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA., Kirberger SE; Department of Chemistry, University of Minnesota, 207 Pleasant Street Southeast, Minneapolis, MN 55455, USA., Pomerantz WCK; Department of Chemistry, University of Minnesota, 207 Pleasant Street Southeast, Minneapolis, MN 55455, USA., Hannon GJ; Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Robinson Way, Cambridge CB20RE, UK. Electronic address: greg.hannon@cruk.cam.ac.uk., Dos Santos CO; Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA. Electronic address: dossanto@cshl.edu.

Publikováno v: Stem cell reports [Stem Cell Reports] 2017 Jul 11; Vol. 9 (1), pp. 23-31. Date of Electronic Publication: 2017 Jun 01.