Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Kiranmayi Vemuri"'
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114242- (2024)
Summary: Terminal differentiation requires massive restructuring of the transcriptome. During intestinal differentiation, the expression patterns of nearly 4,000 genes are altered as cells transition from progenitor cells in crypts to differentiated
Externí odkaz:
https://doaj.org/article/078092799319444eb70df872f85604f0
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Hepatocyte nuclear factor 4-alpha (HNF4α) drives a complex array of transcriptional programs across multiple organs. Beyond its previously documented function in the liver, HNF4α has crucial roles in the kidney, intestine, and pancreas. In the inte
Externí odkaz:
https://doaj.org/article/434b08188b394b8eacde64dfceefd807
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
In the more than 30 years since the purification and cloning of Hepatocyte Nuclear Factor 4 (HNF4α), considerable insight into its role in liver function has been gleaned from its target genes and mouse experiments. HNF4α plays a key role in lipid
Externí odkaz:
https://doaj.org/article/4e1e00eac8fe4d23a54996d9dabee216
Autor:
Mayuresh M. Mane, Ivan J. Cohen, Ellen Ackerstaff, Khalid Shalaby, Jenny N. Ijoma, Myat Ko, Masatomo Maeda, Avi S. Albeg, Kiranmayi Vemuri, Jaya Satagopan, Anna Moroz, Juan Zurita, Larissa Shenker, Masahiro Shindo, Tanner Nickles, Ekaterina Nikolov, Maxim A. Moroz, Jason A. Koutcher, Inna Serganova, Vladimir Ponomarev, Ronald G. Blasberg
Publikováno v:
Molecular Therapy: Oncolytics, Vol 18, Iss , Pp 382-395 (2020)
To enhance human prostate-specific membrane antigen (hPSMA)-specific chimeric antigen receptor (CAR) T cell therapy in a hPSMA+ MyC-CaP tumor model, we studied and imaged the effect of lactate dehydrogenase A (LDH-A) depletion on the tumor microenvir
Externí odkaz:
https://doaj.org/article/26eebb7cb3524556b2f6f1fc9d9dda83
Autor:
Masahiro Shindo, Masatomo Maeda, Ko Myat, Mayuresh M. Mane, Ivan J. Cohen, Kiranmayi Vemuri, Avi S. Albeg, Inna Serganova, Ronald Blasberg
Publikováno v:
Cancers, Vol 14, Iss 9, p 2303 (2022)
Three murine glioma cell lines (GL261, CT2A, and ALTS1C1) were modified to downregulate the expression of the murine LDH-A gene using shRNA, and compared to shRNA scrambled control (NC) cell lines. Differences in the expression of LDH-A and LDH-B mRN
Externí odkaz:
https://doaj.org/article/a1194635288a41b5924c287dc64647d8
Autor:
Masatomo Maeda, Myat Ko, Mayuresh M. Mane, Ivan J. Cohen, Masahiro Shindo, Kiranmayi Vemuri, Inna Serganova, Ronald Blasberg
Publikováno v:
Cancers, Vol 14, Iss 9, p 2306 (2022)
The effects of the LDH-A depletion via shRNA knockdown on three murine glioma cell lines and corresponding intracranial (i.c.) tumors were studied and compared to pharmacologic (GNE-R-140) inhibition of the LDH enzyme complex, and to shRNA scrambled
Externí odkaz:
https://doaj.org/article/571e83cca1194cd6ab42cf82e5f738af
Autor:
Inna Serganova, Ivan J Cohen, Kiranmayi Vemuri, Masahiro Shindo, Masatomo Maeda, Mayuresh Mane, Ekaterina Moroz, Raya Khanin, Jaya Satagopan, Jason A Koutcher, Ronald Blasberg
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0203965 (2018)
Previous studies show that LDH-A knockdown reduces orthotopic 4T1 breast tumor lactate and delays tumor growth and the development of metastases in nude mice. Here, we report significant changes in the tumor microenvironment (TME) and a more robust a
Externí odkaz:
https://doaj.org/article/5aa75257e3324fe2aa3289340a966811
Autor:
Ivan J. Cohen, Kiranmayi Vemuri, Masahiro Shindo, Mayuresh Mane, Masatomo Maeda, Avi S. Albeg, Ronald Blasberg, Ko Myat, Inna Serganova
Background: Lactate metabolism in tumors is now recognized as a major energy source and a major gluconeogenic precursor for many tumors, as well as shown to exhibit signaling properties. There is less information on the role of the LDH/lactate axis i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d98856bf4b7a0b1d04c89ee0700d0d3
https://doi.org/10.21203/rs.3.rs-141065/v1
https://doi.org/10.21203/rs.3.rs-141065/v1
Autor:
Ellen Ackerstaff, Inna Serganova, Ivan J. Cohen, Larissa Shenker, Maxim A. Moroz, Jason A. Koutcher, Myat Ko, Tanner Nickles, Masatomo Maeda, Juan Zurita, Khalid Shalaby, Avi S. Albeg, Jaya M. Satagopan, Vladimir Ponomarev, Ronald G. Blasberg, Masahiro Shindo, Anna Moroz, Kiranmayi Vemuri, Jenny N. Ijoma, Ekaterina Nikolov, Mayuresh Mane
Publikováno v:
Molecular Therapy Oncolytics
Molecular Therapy: Oncolytics, Vol 18, Iss, Pp 382-395 (2020)
Molecular Therapy: Oncolytics, Vol 18, Iss, Pp 382-395 (2020)
To enhance human prostate-specific membrane antigen (hPSMA)-specific chimeric antigen receptor (CAR) T cell therapy in a hPSMA+ MyC-CaP tumor model, we studied and imaged the effect of lactate dehydrogenase A (LDH-A) depletion on the tumor microenvir
Autor:
Kiranmayi Vemuri, Thomas Reiner, Sheryl Roberts, Masatomo Maeda, Roberta Zappasodi, Taha Merghoub, Eric Chan, Ivan J. Cohen, Matthew Lubin, Dmitry Yarilin, Ronald G. Blasberg, Katia Manova-Todorova, Henry Mann, Jason A. Koutcher, Mayuresh Mane, Inna Serganova
Publikováno v:
Cancer Research. 80:1476-1476
Abnormal vessel formation plays a major role in tumor progression. Previously, we showed that lactate dehydrogenase A (LDH-A) knockdown (KD) reduces orthotopic 4T1 breast tumor lactate, and has a robust anti-tumor effect through changes in the tumor