Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Kiranam Chatti"'
Autor:
Keerthana Balamurugan, Raghavender Medishetti, Pallavi Rao, Rahul Varma K, Kiranam Chatti, Kishore V.L. Parsa
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101819- (2022)
Summary: In this report, we describe an approach to generate a zebrafish larval model of lipid accumulation that can be used as an in vivo system to study hyperlipidemic conditions such as atherosclerosis. Furthermore, we detail steps on staining tec
Externí odkaz:
https://doaj.org/article/b5a51f5e18544b4a9546639a20023c5f
Autor:
Raghavender Medishetti, Keerthana Balamurugan, Krishnaveni Yadavalli, Rita Rani, Aarti Sevilimedu, Anil Kumar Challa, Kishore Parsa, Kiranam Chatti
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101779- (2022)
Summary: The application of CRISPR has greatly facilitated genotype-phenotype studies of human disease models. In this protocol, we describe CRISPR-Cas9-induced gene knockout in zebrafish, utilizing purified Cas9 protein and in vitro-transcribed sgRN
Externí odkaz:
https://doaj.org/article/324fb06899d64991bbddeedcf320850e
Autor:
Keerthana Balamurugan, Raghavender Medishetti, Jyothi Kotha, Parameshwar Behera, Kanika Chandra, Vijay Aditya Mavuduru, Manjunath B. Joshi, Ramesh Samineni, Madhumohan R. Katika, Writoban Basu Ball, Manjunatha Thondamal, Anil Challa, Kiranam Chatti, Kishore V.L. Parsa
Publikováno v:
iScience, Vol 25, Iss 2, Pp 103766- (2022)
Summary: Infiltration of arterial intima by foamy macrophages is a hallmark of early atherosclerotic lesions. Here, we investigated the potential role of Ser/Thr phosphatase PHLPP1 in foam cell development. PHLPP1 levels were elevated in OxLDL-expose
Externí odkaz:
https://doaj.org/article/fe4f6b2971f64ef89092d79c791f559d
Autor:
Mani Harika Vemula, Raghavender medisetti, Rakesh Ganji, Kiran Jakkala, Swetha Sankati, Kiranam Chatti, Sharmistha Banerjee
Publikováno v:
Frontiers in Microbiology, Vol 7 (2016)
Zinc metalloprotease-1 (Zmp1) from Mycobacterium tuberculosis (M.tb), the tuberculosis (TB) causing bacillus, is a virulence factor involved in inflammasome inactivation and phagosome maturation arrest. We earlier reported that Zmp1 was secreted unde
Externí odkaz:
https://doaj.org/article/ad9512a8556a40b3a73f459e07d5d8da
Publikováno v:
Biology Methods and Protocols. 8
Site directed mutagenesis is an invaluable technique which enables the elucidation of the contribution of specific residues to protein structure and function. The simultaneous introduction of mutations at a large number of sites (>10), singly and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a75e4310a55b440640057e119a854753
https://doi.org/10.1093/biomethods/bpac037
https://doi.org/10.1093/biomethods/bpac037
Publikováno v:
The journal of contemporary dental practice. 23(2)
Besides conventional vaccinations, viable alternatives are needed to elicit an immune response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We propose and highlight the value of a homeopathic approach known as the "nosode" fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fff5e47357ee513935fe3f817c0accd3
https://pubmed.ncbi.nlm.nih.gov/35748439
https://pubmed.ncbi.nlm.nih.gov/35748439
Publikováno v:
EXPLORE
This report provides a perspective on the relevance of saline water gargling and nasal irrigation to the COVID-19 crisis. While there is limited evidence concerning their curative or preventive role against SARS-CoV-2 infection, previous work on thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc2dd102d9cc1f2a9b106f474f6b24fc
https://doi.org/10.1016/j.explore.2020.09.010
https://doi.org/10.1016/j.explore.2020.09.010
Autor:
B, Thirupataiah, Guntipally, Mounika, Gangireddy, Sujeevan Reddy, Jetta, Sandeep Kumar, Ravikumar, Kapavarapu, Raghavender, Medishetti, Jayesh, Mudgal, Jessy E, Mathew, Gautham G, Shenoy, C, Mallikarjuna Rao, Kiranam, Chatti, Kishore, V L Parsa, Manojit, Pal
Publikováno v:
Bioorganic chemistry. 115
In spite of possessing a wide range of pharmacological properties the anti-inflammatory activities of isoquinolin-1(2H)-ones were rarely known or explored earlier. PDE4 inhibitors on the other hand in addition to their usefulness in treating inflamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fab6367eae7262d990036a230948cf98
https://pubmed.ncbi.nlm.nih.gov/34426160
https://pubmed.ncbi.nlm.nih.gov/34426160
Publikováno v:
MethodsX
Graphical abstract Abstract The development of gene editing technologies, especially the CRISPR-Cas9 system, has been pivotal for understanding the functional role of proteins. Rapid and efficient genotyping methods are necessary to screen for genera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed3d8be158a76ddf7cc661941f60a705
https://doi.org/10.1016/j.mex.2018.11.017
https://doi.org/10.1016/j.mex.2018.11.017
Autor:
B, Thirupataiah, Guntipally, Mounika, Gangireddy Sujeevan, Reddy, Jetta Sandeep, Kumar, Kazi Amirul, Hossain, Raghavender, Medishetti, Snigdha, Samarpita, Mahaboobkhan, Rasool, Jayesh, Mudgal, Jessy E, Mathew, Gautham G, Shenoy, C Mallikarjuna, Rao, Kiranam, Chatti, Kishore V L, Parsa, Manojit, Pal
Publikováno v:
European journal of medicinal chemistry. 221
While anti-inflammatory properties of isocoumarins are known their PDE4 inhibitory potential was not explored previously. In our effort the non-PDE4 inhibitor isocoumarins were transformed into the promising inhibitors via introducing an aminosulfony
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::65e763f432a55d48daf040d57ef951bd
https://pubmed.ncbi.nlm.nih.gov/33992926
https://pubmed.ncbi.nlm.nih.gov/33992926